Repurposing hyperpolarization‐activated cyclic nucleotide‐gated channels as a novel therapy for breast cancer

Repurposing hyperpolarization‐activated cyclic nucleotide‐gated channels as a novel therapy for breast cancer

Abstract Hyperpolarization‐activated cyclic nucleotide‐gated (HCN) channels are members of the voltage‐gated cation channel family known to be expressed in the heart and central nervous system. Ivabradine, a small molecule HCN channel‐blocker, is FDA‐approved for clinical use as a heart rate‐reducin...

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Main Authors: Ka‐Chun Mok, Ho Tsoi, Ellen PS Man, Man‐Hong Leung, Ka Man Chau, Lai‐San Wong, Wing‐Lok Chan, Sum‐Yin Chan, Mai‐Yee Luk, Jessie Y.W. Chan, Jackie K.M. Leung, Yolanda H.Y. Chan, Sellma Batalha, Virginia Lau, David C.W. Siu, Terence K.W. Lee, Chun Gong, Ui‐Soon Khoo
Format: article
Language:EN
Published: Wiley 2021
Subjects:
ER‐stress
HCN
Ivabradine
targeted therapy
triple‐negative breast cancer
Medicine (General)
R5-920
Online Access:https://doaj.org/article/89dc802a66c04d34bba35fe0b981b854
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https://doaj.org/article/89dc802a66c04d34bba35fe0b981b854

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