Composition, isolation, identification and function of adipose tissue-derived exosomes

Exosomes are nano-sized extracellular vesicles (30–160 nm diameter) with lipid bilayer membrane secrete by various cells that mediate the communication between cells and tissue, which contain a variety of non-coding RNAs, mRNAs, proteins, lipids and other functional substances. Adipose tissue is imp...

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Autores principales:	Rui Zhao, Tiantian Zhao, Zhaozhao He, Rui Cai, Weijun Pang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	adipose tissue-derived exosomes composition isolation identification cancer cardiovascular diseases Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/89dd4d1eea7f450baad21dc8c0df20a1
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id	oai:doaj.org-article:89dd4d1eea7f450baad21dc8c0df20a1
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spelling	oai:doaj.org-article:89dd4d1eea7f450baad21dc8c0df20a12021-11-26T11:19:49ZComposition, isolation, identification and function of adipose tissue-derived exosomes2162-39452162-397X10.1080/21623945.2021.1983242https://doaj.org/article/89dd4d1eea7f450baad21dc8c0df20a12021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/21623945.2021.1983242https://doaj.org/toc/2162-3945https://doaj.org/toc/2162-397XExosomes are nano-sized extracellular vesicles (30–160 nm diameter) with lipid bilayer membrane secrete by various cells that mediate the communication between cells and tissue, which contain a variety of non-coding RNAs, mRNAs, proteins, lipids and other functional substances. Adipose tissue is important energy storage and endocrine organ in the organism. Recent studies have revealed that adipose tissue-derived exosomes (AT-Exosomes) play a critical role in many physiologically and pathologically functions. Physiologically, AT-Exosomes could regulate the metabolic homoeostasis of various organs or cells including liver and skeletal muscle. Pathologically, they could be used in the treatment of disease and or that they may be involved in the progression of the disease. In this review, we describe the basic principles and methods of exosomes isolation and identification, as well as further summary the specific methods. Moreover, we categorize the relevant studies of AT-Exosomes and summarize the different components and biological functions of mammalian exosomes. Most importantly, we elaborate AT-Exosomes crosstalk within adipose tissue and their functions on other tissues or organs from the physiological and pathological perspective. Based on the above analysis, we discuss what remains to be discovered problems in AT-Exosomes studies and prospect their directions needed to be further explored in the future.Rui ZhaoTiantian ZhaoZhaozhao HeRui CaiWeijun PangTaylor & Francis Grouparticleadipose tissue-derived exosomescompositionisolationidentificationcancercardiovascular diseasesDiseases of the endocrine glands. Clinical endocrinologyRC648-665CytologyQH573-671PhysiologyQP1-981ENAdipocyte, Vol 10, Iss 1, Pp 587-604 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	adipose tissue-derived exosomes composition isolation identification cancer cardiovascular diseases Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981
spellingShingle	adipose tissue-derived exosomes composition isolation identification cancer cardiovascular diseases Diseases of the endocrine glands. Clinical endocrinology RC648-665 Cytology QH573-671 Physiology QP1-981 Rui Zhao Tiantian Zhao Zhaozhao He Rui Cai Weijun Pang Composition, isolation, identification and function of adipose tissue-derived exosomes
description	Exosomes are nano-sized extracellular vesicles (30–160 nm diameter) with lipid bilayer membrane secrete by various cells that mediate the communication between cells and tissue, which contain a variety of non-coding RNAs, mRNAs, proteins, lipids and other functional substances. Adipose tissue is important energy storage and endocrine organ in the organism. Recent studies have revealed that adipose tissue-derived exosomes (AT-Exosomes) play a critical role in many physiologically and pathologically functions. Physiologically, AT-Exosomes could regulate the metabolic homoeostasis of various organs or cells including liver and skeletal muscle. Pathologically, they could be used in the treatment of disease and or that they may be involved in the progression of the disease. In this review, we describe the basic principles and methods of exosomes isolation and identification, as well as further summary the specific methods. Moreover, we categorize the relevant studies of AT-Exosomes and summarize the different components and biological functions of mammalian exosomes. Most importantly, we elaborate AT-Exosomes crosstalk within adipose tissue and their functions on other tissues or organs from the physiological and pathological perspective. Based on the above analysis, we discuss what remains to be discovered problems in AT-Exosomes studies and prospect their directions needed to be further explored in the future.
format	article
author	Rui Zhao Tiantian Zhao Zhaozhao He Rui Cai Weijun Pang
author_facet	Rui Zhao Tiantian Zhao Zhaozhao He Rui Cai Weijun Pang
author_sort	Rui Zhao
title	Composition, isolation, identification and function of adipose tissue-derived exosomes
title_short	Composition, isolation, identification and function of adipose tissue-derived exosomes
title_full	Composition, isolation, identification and function of adipose tissue-derived exosomes
title_fullStr	Composition, isolation, identification and function of adipose tissue-derived exosomes
title_full_unstemmed	Composition, isolation, identification and function of adipose tissue-derived exosomes
title_sort	composition, isolation, identification and function of adipose tissue-derived exosomes
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/89dd4d1eea7f450baad21dc8c0df20a1
work_keys_str_mv	AT ruizhao compositionisolationidentificationandfunctionofadiposetissuederivedexosomes AT tiantianzhao compositionisolationidentificationandfunctionofadiposetissuederivedexosomes AT zhaozhaohe compositionisolationidentificationandfunctionofadiposetissuederivedexosomes AT ruicai compositionisolationidentificationandfunctionofadiposetissuederivedexosomes AT weijunpang compositionisolationidentificationandfunctionofadiposetissuederivedexosomes
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Composition, isolation, identification and function of adipose tissue-derived exosomes

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