Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis

The study was aimed to determine the association of the platelet-lymphocyte ratio (PLR) with the disease activity of ankylosing spondylitis (AS). A total of 275 patients, including 180 AS patients and 95 non-AS patients, participated in the study. We assessed a full blood count for each participant....

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Autores principales:	Tuo Liang, Jiarui Chen, Guoyong Xu, Zide Zhang, Jiang Xue, Haopeng Zeng, Jie Jiang, Tianyou Chen, Zhaojie Qin, Hao Li, Zhen Ye, Yunfeng Nie, Xinli Zhan, Chong Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	AS PLR nomogram diagnosis severity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/89de4c5af24942f7bcaa6e020399039f
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spelling	oai:doaj.org-article:89de4c5af24942f7bcaa6e020399039f2021-11-05T12:25:25ZPlatelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis1664-322410.3389/fimmu.2021.760214https://doaj.org/article/89de4c5af24942f7bcaa6e020399039f2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.760214/fullhttps://doaj.org/toc/1664-3224The study was aimed to determine the association of the platelet-lymphocyte ratio (PLR) with the disease activity of ankylosing spondylitis (AS). A total of 275 patients, including 180 AS patients and 95 non-AS patients, participated in the study. We assessed a full blood count for each participant. Platelet to monocyte ratio (PMR), monocytes to lymphocyte ratio (MLR), monocyte to neutrophil ratio (MNR), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and platelet to neutrophil ratio (PNR) were calculated. LASSO and logistic regression analyses were performed to establish the nomogram. Receiver operating characteristic (ROC) analysis was performed to evaluate the clinical value of the nomogram. We constructed a novel nomogram, which incorporated easily accessible clinical characteristics like sex, PLR, WBC, EOS, and ESR for AS diagnosis. The AUC value of this nomogram was 0.806; also, the calibration curves indicated a satisfactory agreement between nomogram prediction and actual probabilities. Furthermore, PLR was positively correlated with the severity of AS. PLR was identified as an independent factor for the diagnosis of AS and was associated with the severity of AS.Tuo LiangJiarui ChenGuoyong XuZide ZhangJiang XueHaopeng ZengJie JiangTianyou ChenZhaojie QinHao LiZhen YeYunfeng NieXinli ZhanChong LiuFrontiers Media S.A.articleASPLRnomogramdiagnosisseverityImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AS PLR nomogram diagnosis severity Immunologic diseases. Allergy RC581-607
spellingShingle	AS PLR nomogram diagnosis severity Immunologic diseases. Allergy RC581-607 Tuo Liang Jiarui Chen Guoyong Xu Zide Zhang Jiang Xue Haopeng Zeng Jie Jiang Tianyou Chen Zhaojie Qin Hao Li Zhen Ye Yunfeng Nie Xinli Zhan Chong Liu Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis
description	The study was aimed to determine the association of the platelet-lymphocyte ratio (PLR) with the disease activity of ankylosing spondylitis (AS). A total of 275 patients, including 180 AS patients and 95 non-AS patients, participated in the study. We assessed a full blood count for each participant. Platelet to monocyte ratio (PMR), monocytes to lymphocyte ratio (MLR), monocyte to neutrophil ratio (MNR), platelet to lymphocyte ratio (PLR), neutrophil to lymphocyte ratio (NLR), and platelet to neutrophil ratio (PNR) were calculated. LASSO and logistic regression analyses were performed to establish the nomogram. Receiver operating characteristic (ROC) analysis was performed to evaluate the clinical value of the nomogram. We constructed a novel nomogram, which incorporated easily accessible clinical characteristics like sex, PLR, WBC, EOS, and ESR for AS diagnosis. The AUC value of this nomogram was 0.806; also, the calibration curves indicated a satisfactory agreement between nomogram prediction and actual probabilities. Furthermore, PLR was positively correlated with the severity of AS. PLR was identified as an independent factor for the diagnosis of AS and was associated with the severity of AS.
format	article
author	Tuo Liang Jiarui Chen Guoyong Xu Zide Zhang Jiang Xue Haopeng Zeng Jie Jiang Tianyou Chen Zhaojie Qin Hao Li Zhen Ye Yunfeng Nie Xinli Zhan Chong Liu
author_facet	Tuo Liang Jiarui Chen Guoyong Xu Zide Zhang Jiang Xue Haopeng Zeng Jie Jiang Tianyou Chen Zhaojie Qin Hao Li Zhen Ye Yunfeng Nie Xinli Zhan Chong Liu
author_sort	Tuo Liang
title	Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis
title_short	Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis
title_full	Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis
title_fullStr	Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis
title_full_unstemmed	Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis
title_sort	platelet-to-lymphocyte ratio as an independent factor was associated with the severity of ankylosing spondylitis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/89de4c5af24942f7bcaa6e020399039f
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Platelet-to-Lymphocyte Ratio as an Independent Factor Was Associated With the Severity of Ankylosing Spondylitis

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