SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer

SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer

ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell inv...

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Autores principales: Ylenia Perone, Aaron J. Farrugia, Alba Rodríguez-Meira, Balázs Győrffy, Charlotte Ion, Andrea Uggetti, Antonios Chronopoulos, Pasquale Marrazzo, Monica Faronato, Sami Shousha, Claire Davies, Jennifer H. Steel, Naina Patel, Armando del Rio Hernandez, Charles Coombes, Giancarlo Pruneri, Adrian Lim, Fernando Calvo, Luca Magnani
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/89df65835066448cbf1f8b48e72f3298
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spelling oai:doaj.org-article:89df65835066448cbf1f8b48e72f32982021-12-02T15:36:04ZSREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer10.1038/s41467-019-09676-y2041-1723https://doaj.org/article/89df65835066448cbf1f8b48e72f32982019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09676-yhttps://doaj.org/toc/2041-1723ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell invasion.Ylenia PeroneAaron J. FarrugiaAlba Rodríguez-MeiraBalázs GyőrffyCharlotte IonAndrea UggettiAntonios ChronopoulosPasquale MarrazzoMonica FaronatoSami ShoushaClaire DaviesJennifer H. SteelNaina PatelArmando del Rio HernandezCharles CoombesGiancarlo PruneriAdrian LimFernando CalvoLuca MagnaniNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ylenia Perone
Aaron J. Farrugia
Alba Rodríguez-Meira
Balázs Győrffy
Charlotte Ion
Andrea Uggetti
Antonios Chronopoulos
Pasquale Marrazzo
Monica Faronato
Sami Shousha
Claire Davies
Jennifer H. Steel
Naina Patel
Armando del Rio Hernandez
Charles Coombes
Giancarlo Pruneri
Adrian Lim
Fernando Calvo
Luca Magnani
SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
description ERα breast cancer can relapse to metastatic disease following endocrine therapy. Here, the authors find that when aromatase inhibitor treatment resistance develops, epigenomic reprogramming drives Keratin-80 upregulation via SREBP1, and promotes cytoskeletal rearrangements that drive cancer cell invasion.
format article
author Ylenia Perone
Aaron J. Farrugia
Alba Rodríguez-Meira
Balázs Győrffy
Charlotte Ion
Andrea Uggetti
Antonios Chronopoulos
Pasquale Marrazzo
Monica Faronato
Sami Shousha
Claire Davies
Jennifer H. Steel
Naina Patel
Armando del Rio Hernandez
Charles Coombes
Giancarlo Pruneri
Adrian Lim
Fernando Calvo
Luca Magnani
author_facet Ylenia Perone
Aaron J. Farrugia
Alba Rodríguez-Meira
Balázs Győrffy
Charlotte Ion
Andrea Uggetti
Antonios Chronopoulos
Pasquale Marrazzo
Monica Faronato
Sami Shousha
Claire Davies
Jennifer H. Steel
Naina Patel
Armando del Rio Hernandez
Charles Coombes
Giancarlo Pruneri
Adrian Lim
Fernando Calvo
Luca Magnani
author_sort Ylenia Perone
title SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
title_short SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
title_full SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
title_fullStr SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
title_full_unstemmed SREBP1 drives Keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant ERα breast cancer
title_sort srebp1 drives keratin-80-dependent cytoskeletal changes and invasive behavior in endocrine-resistant erα breast cancer
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/89df65835066448cbf1f8b48e72f3298
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