The complex evolution of the metazoan HSP70 gene family

Abstract The metazoan 70-kDa heat shock protein (HSP70) family contains several members localized in different subcellular compartments. The cytosolic members have been classified into inducible HSP70s and constitutive heat shock cognates (HSC70s), but their distinction and evolutionary relationship...

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Autores principales:	Er-meng Yu, Tatsuki Yoshinaga, Frank L. Jalufka, Hashimul Ehsan, David B. Mark Welch, Gen Kaneko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89e1bd73a1d24ed3903ee2f1e8388307
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spelling	oai:doaj.org-article:89e1bd73a1d24ed3903ee2f1e83883072021-12-02T17:19:15ZThe complex evolution of the metazoan HSP70 gene family10.1038/s41598-021-97192-92045-2322https://doaj.org/article/89e1bd73a1d24ed3903ee2f1e83883072021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97192-9https://doaj.org/toc/2045-2322Abstract The metazoan 70-kDa heat shock protein (HSP70) family contains several members localized in different subcellular compartments. The cytosolic members have been classified into inducible HSP70s and constitutive heat shock cognates (HSC70s), but their distinction and evolutionary relationship remain unclear because of occasional reports of “constitutive HSP70s” and the lack of cross-phylum comparisons. Here we provide novel insights into the evolution of these important molecular chaperones. Phylogenetic analyses of 125 full-length HSP70s from a broad range of phyla revealed an ancient duplication that gave rise to two lineages from which all metazoan cytosolic HSP70s descend. One lineage (A) contains a relatively small number of genes from many invertebrate phyla, none of which have been shown to be constitutively expressed (i.e., either inducible or unknown). The other lineage (B) included both inducible and constitutive genes from diverse phyla. Species-specific duplications are present in both lineages, and Lineage B contains well-supported phylum-specific clades for Platyhelminthes, Rotifera, Nematoda, Porifera/Cnidaria, and Chordata. Some genes in Lineage B have likely independently acquired inducibility, which may explain the sporadic distribution of “HSP70” or “HSC70” in previous phylogenetic analyses. Consistent with the diversification history within each group, inducible members show lower purifying selection pressure compared to constitutive members. These results illustrate the evolutionary history of the HSP70 family, encouraging us to propose a new nomenclature: “HSP70 + subcellular localization + linage + copy number in the organism + inducible or constitutive, if known.” e.g., HSP70cA1i for cytosolic Lineage A, copy 1, inducible.Er-meng YuTatsuki YoshinagaFrank L. JalufkaHashimul EhsanDavid B. Mark WelchGen KanekoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Er-meng Yu Tatsuki Yoshinaga Frank L. Jalufka Hashimul Ehsan David B. Mark Welch Gen Kaneko The complex evolution of the metazoan HSP70 gene family
description	Abstract The metazoan 70-kDa heat shock protein (HSP70) family contains several members localized in different subcellular compartments. The cytosolic members have been classified into inducible HSP70s and constitutive heat shock cognates (HSC70s), but their distinction and evolutionary relationship remain unclear because of occasional reports of “constitutive HSP70s” and the lack of cross-phylum comparisons. Here we provide novel insights into the evolution of these important molecular chaperones. Phylogenetic analyses of 125 full-length HSP70s from a broad range of phyla revealed an ancient duplication that gave rise to two lineages from which all metazoan cytosolic HSP70s descend. One lineage (A) contains a relatively small number of genes from many invertebrate phyla, none of which have been shown to be constitutively expressed (i.e., either inducible or unknown). The other lineage (B) included both inducible and constitutive genes from diverse phyla. Species-specific duplications are present in both lineages, and Lineage B contains well-supported phylum-specific clades for Platyhelminthes, Rotifera, Nematoda, Porifera/Cnidaria, and Chordata. Some genes in Lineage B have likely independently acquired inducibility, which may explain the sporadic distribution of “HSP70” or “HSC70” in previous phylogenetic analyses. Consistent with the diversification history within each group, inducible members show lower purifying selection pressure compared to constitutive members. These results illustrate the evolutionary history of the HSP70 family, encouraging us to propose a new nomenclature: “HSP70 + subcellular localization + linage + copy number in the organism + inducible or constitutive, if known.” e.g., HSP70cA1i for cytosolic Lineage A, copy 1, inducible.
format	article
author	Er-meng Yu Tatsuki Yoshinaga Frank L. Jalufka Hashimul Ehsan David B. Mark Welch Gen Kaneko
author_facet	Er-meng Yu Tatsuki Yoshinaga Frank L. Jalufka Hashimul Ehsan David B. Mark Welch Gen Kaneko
author_sort	Er-meng Yu
title	The complex evolution of the metazoan HSP70 gene family
title_short	The complex evolution of the metazoan HSP70 gene family
title_full	The complex evolution of the metazoan HSP70 gene family
title_fullStr	The complex evolution of the metazoan HSP70 gene family
title_full_unstemmed	The complex evolution of the metazoan HSP70 gene family
title_sort	complex evolution of the metazoan hsp70 gene family
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89e1bd73a1d24ed3903ee2f1e8388307
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The complex evolution of the metazoan HSP70 gene family

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