Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study

The cause of some patients with negative RT-PCR results experienced turn-positive after treatment remains unclear. In addition, understanding the correlation between changes in clinical data in the course of COVID-19 and treatment outcomes is of great importance in determining the prognosis of COVID...

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Autores principales:	Yong Xiao, Xiao Shi, Qian She, Qi Chen, Hong Pan, Jin Zhang, Xiaojiao Liu, Haiyan Wu, Wenfei Jin, Ge Ke, Shuzhong Liu, Jiao Li, Jing Zhou, Dongwen Wu, Fen Wang, Honggang Yu, Mingkai Chen
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2020
Materias:	covid-19 turn-positive recurrence clinical outcomes cohort study Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/89ea16e909384a1e9d1a20704beef570
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spelling	oai:doaj.org-article:89ea16e909384a1e9d1a20704beef5702021-11-17T14:21:59ZExploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study2150-55942150-560810.1080/21505594.2020.1816076https://doaj.org/article/89ea16e909384a1e9d1a20704beef5702020-12-01T00:00:00Zhttp://dx.doi.org/10.1080/21505594.2020.1816076https://doaj.org/toc/2150-5594https://doaj.org/toc/2150-5608The cause of some patients with negative RT-PCR results experienced turn-positive after treatment remains unclear. In addition, understanding the correlation between changes in clinical data in the course of COVID-19 and treatment outcomes is of great importance in determining the prognosis of COVID-19. To perform cause analysis of RT-PCR turn-positive and the effective screening factors related to treatment outcome in COVID-19. Clinical data, including clinical manifestations, laboratory tests, radiography results, treatment methods and outcomes, were retrospectively collected and analyzed from January to March 2020 in Renmin Hospitals of Wuhan University. 116 COVID-19 patients (40 in recurrent group, 29 in recovered group and 47 in unrecovered group) were recruited. In the recurrent group, white blood cell, Neutrophils, prothrombin time, activated partial thromboplastin time, CD3, CD4, CD8, ratio of CD4/CD8, IgG and C4 complement were of significant difference among the baseline, negative and turn-positive time points. CD19 and CT scan results were found notable difference between recurrent group and recovered group. Odds from CD3, CD4, CD8, CD19, IgM, C3 complement, C4 complement and CT scan results validated associations with clinical outcomes of COVID-19. The so-called recurrence in some COVID-19 patients may be due to the false-negative of nucleic acid test results from nasopharyngeal swabs. Levels of CD3, CD4, CD8, CD19, IgM, C3 complement, C4 complement and CT results were significantly correlated with the outcome of COVID-19. The cellular immunity test could be beneficial to further screen the reliability of RT-PCR test on the basis of CT images.Yong XiaoXiao ShiQian SheQi ChenHong PanJin ZhangXiaojiao LiuHaiyan WuWenfei JinGe KeShuzhong LiuJiao LiJing ZhouDongwen WuFen WangHonggang YuMingkai ChenTaylor & Francis Grouparticlecovid-19turn-positiverecurrenceclinical outcomescohort studyInfectious and parasitic diseasesRC109-216ENVirulence, Vol 11, Iss 1, Pp 1250-1256 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 turn-positive recurrence clinical outcomes cohort study Infectious and parasitic diseases RC109-216
spellingShingle	covid-19 turn-positive recurrence clinical outcomes cohort study Infectious and parasitic diseases RC109-216 Yong Xiao Xiao Shi Qian She Qi Chen Hong Pan Jin Zhang Xiaojiao Liu Haiyan Wu Wenfei Jin Ge Ke Shuzhong Liu Jiao Li Jing Zhou Dongwen Wu Fen Wang Honggang Yu Mingkai Chen Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study
description	The cause of some patients with negative RT-PCR results experienced turn-positive after treatment remains unclear. In addition, understanding the correlation between changes in clinical data in the course of COVID-19 and treatment outcomes is of great importance in determining the prognosis of COVID-19. To perform cause analysis of RT-PCR turn-positive and the effective screening factors related to treatment outcome in COVID-19. Clinical data, including clinical manifestations, laboratory tests, radiography results, treatment methods and outcomes, were retrospectively collected and analyzed from January to March 2020 in Renmin Hospitals of Wuhan University. 116 COVID-19 patients (40 in recurrent group, 29 in recovered group and 47 in unrecovered group) were recruited. In the recurrent group, white blood cell, Neutrophils, prothrombin time, activated partial thromboplastin time, CD3, CD4, CD8, ratio of CD4/CD8, IgG and C4 complement were of significant difference among the baseline, negative and turn-positive time points. CD19 and CT scan results were found notable difference between recurrent group and recovered group. Odds from CD3, CD4, CD8, CD19, IgM, C3 complement, C4 complement and CT scan results validated associations with clinical outcomes of COVID-19. The so-called recurrence in some COVID-19 patients may be due to the false-negative of nucleic acid test results from nasopharyngeal swabs. Levels of CD3, CD4, CD8, CD19, IgM, C3 complement, C4 complement and CT results were significantly correlated with the outcome of COVID-19. The cellular immunity test could be beneficial to further screen the reliability of RT-PCR test on the basis of CT images.
format	article
author	Yong Xiao Xiao Shi Qian She Qi Chen Hong Pan Jin Zhang Xiaojiao Liu Haiyan Wu Wenfei Jin Ge Ke Shuzhong Liu Jiao Li Jing Zhou Dongwen Wu Fen Wang Honggang Yu Mingkai Chen
author_facet	Yong Xiao Xiao Shi Qian She Qi Chen Hong Pan Jin Zhang Xiaojiao Liu Haiyan Wu Wenfei Jin Ge Ke Shuzhong Liu Jiao Li Jing Zhou Dongwen Wu Fen Wang Honggang Yu Mingkai Chen
author_sort	Yong Xiao
title	Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study
title_short	Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study
title_full	Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study
title_fullStr	Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study
title_full_unstemmed	Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study
title_sort	exploration of turn-positive rt-pcr results and factors related to treatment outcome in covid-19: a retrospective cohort study
publisher	Taylor & Francis Group
publishDate	2020
url	https://doaj.org/article/89ea16e909384a1e9d1a20704beef570
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Exploration of turn-positive RT-PCR results and factors related to treatment outcome in COVID-19: A retrospective cohort study

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