Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
Codon 158 gain-of-function mutant p53 (158-mutp53) promotes tumourigenesis in lung cancer. Here, the authors show that 158-mutp53 render cancers sensitive to cisplatin and p53 acetylation agents through a mechanism where acetylated mutant p53 upregulates TRAIP and inhibits NF-ĸB signaling.
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Nature Portfolio
2020
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oai:doaj.org-article:89ea4992ac4f465ea6d7ca0e0a05a0dd2021-12-02T16:49:45ZTargeting codon 158 p53-mutant cancers via the induction of p53 acetylation10.1038/s41467-020-15608-y2041-1723https://doaj.org/article/89ea4992ac4f465ea6d7ca0e0a05a0dd2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15608-yhttps://doaj.org/toc/2041-1723Codon 158 gain-of-function mutant p53 (158-mutp53) promotes tumourigenesis in lung cancer. Here, the authors show that 158-mutp53 render cancers sensitive to cisplatin and p53 acetylation agents through a mechanism where acetylated mutant p53 upregulates TRAIP and inhibits NF-ĸB signaling.Li Ren KongRichard Weijie OngTuan Zea TanNur Afiqah Binte Mohamed SallehMatan ThangaveluJane Vin ChanLie Yong Judice KohGiridharan PeriyasamyJieying Amelia LauThi Bich Uyen LeLingzhi WangMiyoung LeeSrinivasaraghavan KannanChandra S. VermaChwee Ming LimWee Joo ChngDavid P. LaneAshok VenkitaramanHuynh The HungChit Fang CheokBoon Cher GohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Li Ren Kong Richard Weijie Ong Tuan Zea Tan Nur Afiqah Binte Mohamed Salleh Matan Thangavelu Jane Vin Chan Lie Yong Judice Koh Giridharan Periyasamy Jieying Amelia Lau Thi Bich Uyen Le Lingzhi Wang Miyoung Lee Srinivasaraghavan Kannan Chandra S. Verma Chwee Ming Lim Wee Joo Chng David P. Lane Ashok Venkitaraman Huynh The Hung Chit Fang Cheok Boon Cher Goh Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| description |
Codon 158 gain-of-function mutant p53 (158-mutp53) promotes tumourigenesis in lung cancer. Here, the authors show that 158-mutp53 render cancers sensitive to cisplatin and p53 acetylation agents through a mechanism where acetylated mutant p53 upregulates TRAIP and inhibits NF-ĸB signaling. |
| format |
article |
| author |
Li Ren Kong Richard Weijie Ong Tuan Zea Tan Nur Afiqah Binte Mohamed Salleh Matan Thangavelu Jane Vin Chan Lie Yong Judice Koh Giridharan Periyasamy Jieying Amelia Lau Thi Bich Uyen Le Lingzhi Wang Miyoung Lee Srinivasaraghavan Kannan Chandra S. Verma Chwee Ming Lim Wee Joo Chng David P. Lane Ashok Venkitaraman Huynh The Hung Chit Fang Cheok Boon Cher Goh |
| author_facet |
Li Ren Kong Richard Weijie Ong Tuan Zea Tan Nur Afiqah Binte Mohamed Salleh Matan Thangavelu Jane Vin Chan Lie Yong Judice Koh Giridharan Periyasamy Jieying Amelia Lau Thi Bich Uyen Le Lingzhi Wang Miyoung Lee Srinivasaraghavan Kannan Chandra S. Verma Chwee Ming Lim Wee Joo Chng David P. Lane Ashok Venkitaraman Huynh The Hung Chit Fang Cheok Boon Cher Goh |
| author_sort |
Li Ren Kong |
| title |
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| title_short |
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| title_full |
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| title_fullStr |
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| title_full_unstemmed |
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| title_sort |
targeting codon 158 p53-mutant cancers via the induction of p53 acetylation |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/89ea4992ac4f465ea6d7ca0e0a05a0dd |
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