The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses

Abstract Brown adipose tissue (BAT) is regulated by the sympathetic nervous system via β3-adrenergic receptors (β3-AR). Here we tested the hypothesis that pharmacological stimulation of β3-ARs leads to increased sleep in mice and if this change is BAT dependent. In wild-type (WT) animals, administra...

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Autores principales:	Éva Szentirmai, Levente Kapás
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89ec27d961f44502b99cfe1d6d7a6514
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spelling	oai:doaj.org-article:89ec27d961f44502b99cfe1d6d7a65142021-12-02T16:08:00ZThe role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses10.1038/s41598-017-01047-12045-2322https://doaj.org/article/89ec27d961f44502b99cfe1d6d7a65142017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01047-1https://doaj.org/toc/2045-2322Abstract Brown adipose tissue (BAT) is regulated by the sympathetic nervous system via β3-adrenergic receptors (β3-AR). Here we tested the hypothesis that pharmacological stimulation of β3-ARs leads to increased sleep in mice and if this change is BAT dependent. In wild-type (WT) animals, administration of CL-316,243, a selective β3-AR agonist, induced significant increases in non-rapid-eye movement sleep (NREMS) lasting for 4–10 h. Simultaneously, electroencephalographic slow-wave activity (SWA) was significantly decreased and body temperature was increased with a delay of 5–6 h. In uncoupling protein 1 (UCP-1) knockout mice, the middle and highest doses of the β3-AR agonist increased sleep and suppressed SWA, however, these effects were significantly attenuated and shorter-lasting as compared to WT animals. To determine if somnogenic signals arising from BAT in response to β3-AR stimulation are mediated by the sensory afferents of BAT, we tested the effects of CL-316,243 in mice with the chemical deafferentation of the intra-scapular BAT pads. Sleep responses to CL-316,243 were attenuated by ~50% in intra-BAT capsaicin-treated mice. Present findings indicate that the activation of BAT via β3-AR leads to increased sleep in mice and that this effect is dependent on the presence of UCP-1 protein and sleep responses require the intact sensory innervation of BAT.Éva SzentirmaiLevente KapásNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Éva Szentirmai Levente Kapás The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
description	Abstract Brown adipose tissue (BAT) is regulated by the sympathetic nervous system via β3-adrenergic receptors (β3-AR). Here we tested the hypothesis that pharmacological stimulation of β3-ARs leads to increased sleep in mice and if this change is BAT dependent. In wild-type (WT) animals, administration of CL-316,243, a selective β3-AR agonist, induced significant increases in non-rapid-eye movement sleep (NREMS) lasting for 4–10 h. Simultaneously, electroencephalographic slow-wave activity (SWA) was significantly decreased and body temperature was increased with a delay of 5–6 h. In uncoupling protein 1 (UCP-1) knockout mice, the middle and highest doses of the β3-AR agonist increased sleep and suppressed SWA, however, these effects were significantly attenuated and shorter-lasting as compared to WT animals. To determine if somnogenic signals arising from BAT in response to β3-AR stimulation are mediated by the sensory afferents of BAT, we tested the effects of CL-316,243 in mice with the chemical deafferentation of the intra-scapular BAT pads. Sleep responses to CL-316,243 were attenuated by ~50% in intra-BAT capsaicin-treated mice. Present findings indicate that the activation of BAT via β3-AR leads to increased sleep in mice and that this effect is dependent on the presence of UCP-1 protein and sleep responses require the intact sensory innervation of BAT.
format	article
author	Éva Szentirmai Levente Kapás
author_facet	Éva Szentirmai Levente Kapás
author_sort	Éva Szentirmai
title	The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
title_short	The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
title_full	The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
title_fullStr	The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
title_full_unstemmed	The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
title_sort	role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/89ec27d961f44502b99cfe1d6d7a6514
work_keys_str_mv	AT evaszentirmai theroleofthebrownadiposetissueinb3adrenergicreceptoractivationinducedsleepmetabolicandfeedingresponses AT leventekapas theroleofthebrownadiposetissueinb3adrenergicreceptoractivationinducedsleepmetabolicandfeedingresponses AT evaszentirmai roleofthebrownadiposetissueinb3adrenergicreceptoractivationinducedsleepmetabolicandfeedingresponses AT leventekapas roleofthebrownadiposetissueinb3adrenergicreceptoractivationinducedsleepmetabolicandfeedingresponses
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The role of the brown adipose tissue in β3-adrenergic receptor activation-induced sleep, metabolic and feeding responses

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