Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

ABSTRACT HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef’s downregulation activity. However, t...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Acceso en línea:https://doaj.org/article/89ef5bd0118b44c7bdbff19549c0ad89
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!