Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences
ABSTRACT HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef’s downregulation activity. However, t...
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| Main Authors: | , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2016
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| Subjects: | |
| Online Access: | https://doaj.org/article/89ef5bd0118b44c7bdbff19549c0ad89 |
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