Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey.
<h4>Background</h4>Bone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease in RCC.<h4>Patients and methods</h4>Data on clinicopathology, su...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2013
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/89f1cff242564bc3a6ef30e3f7975439 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:89f1cff242564bc3a6ef30e3f7975439 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:89f1cff242564bc3a6ef30e3f79754392021-11-18T08:39:57ZNatural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey.1932-620310.1371/journal.pone.0083026https://doaj.org/article/89f1cff242564bc3a6ef30e3f79754392013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24386138/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Bone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease in RCC.<h4>Patients and methods</h4>Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 398 deceased RCC patients (286 male, 112 female) with evidence of bone metastasis were statistically analyzed.<h4>Results</h4>Median time to bone metastasis was 25 months for patients without bone metastasis at diagnosis. Median time to diagnosis of bone metastasis by MSKCC risk was 24 months for good, 5 months for intermediate, and 0 months for poor risk. Median number of SREs/patient was one, and 71% of patients experienced at least one SRE. Median times to first, second, and third SRE were 2, 5, and 12 months, respectively. Median survival was 12 months after bone metastasis diagnosis and 10 months after first SRE. Among 181 patients who received zoledronic acid (ZOL), median time to first SRE was significantly prolonged versus control (n = 186) (3 months vs 1 month for control; P<0.05).<h4>Conclusions</h4>RCC patients with bone metastasis are at continuous risk of SREs, and in this survey ZOL effectively reduced this risk.Daniele SantiniGiuseppe ProcopioCamillo PortaToni IbrahimSandro BarniCalogero MazzaraAndrea FontanaAlfredo BerrutiRossana BerardiBruno VincenziCinzia OrtegaDavide OttavianiGiacomo CarteniGaetano LanzettaVladimir VirzìMatteo SantoniNicola SilvestrisMaria Antonietta SatolliElena CollovàAntonio RussoGiuseppe BadalamentiStefano Luzi FedeliFrancesca Maria TancaVincenzo AdamoEvaristo MaielloRoberto SabbatiniAlessandra FeliciSaverio CinieriGiuseppe ToniniSergio BracardaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83026 (2013) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Daniele Santini Giuseppe Procopio Camillo Porta Toni Ibrahim Sandro Barni Calogero Mazzara Andrea Fontana Alfredo Berruti Rossana Berardi Bruno Vincenzi Cinzia Ortega Davide Ottaviani Giacomo Carteni Gaetano Lanzetta Vladimir Virzì Matteo Santoni Nicola Silvestris Maria Antonietta Satolli Elena Collovà Antonio Russo Giuseppe Badalamenti Stefano Luzi Fedeli Francesca Maria Tanca Vincenzo Adamo Evaristo Maiello Roberto Sabbatini Alessandra Felici Saverio Cinieri Giuseppe Tonini Sergio Bracarda Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. |
| description |
<h4>Background</h4>Bone metastasis represents an increasing clinical problem in advanced renal cell carcinoma (RCC) as disease-related survival improves. There are few data on the natural history of bone disease in RCC.<h4>Patients and methods</h4>Data on clinicopathology, survival, skeletal-related events (SREs), and bone-directed therapies for 398 deceased RCC patients (286 male, 112 female) with evidence of bone metastasis were statistically analyzed.<h4>Results</h4>Median time to bone metastasis was 25 months for patients without bone metastasis at diagnosis. Median time to diagnosis of bone metastasis by MSKCC risk was 24 months for good, 5 months for intermediate, and 0 months for poor risk. Median number of SREs/patient was one, and 71% of patients experienced at least one SRE. Median times to first, second, and third SRE were 2, 5, and 12 months, respectively. Median survival was 12 months after bone metastasis diagnosis and 10 months after first SRE. Among 181 patients who received zoledronic acid (ZOL), median time to first SRE was significantly prolonged versus control (n = 186) (3 months vs 1 month for control; P<0.05).<h4>Conclusions</h4>RCC patients with bone metastasis are at continuous risk of SREs, and in this survey ZOL effectively reduced this risk. |
| format |
article |
| author |
Daniele Santini Giuseppe Procopio Camillo Porta Toni Ibrahim Sandro Barni Calogero Mazzara Andrea Fontana Alfredo Berruti Rossana Berardi Bruno Vincenzi Cinzia Ortega Davide Ottaviani Giacomo Carteni Gaetano Lanzetta Vladimir Virzì Matteo Santoni Nicola Silvestris Maria Antonietta Satolli Elena Collovà Antonio Russo Giuseppe Badalamenti Stefano Luzi Fedeli Francesca Maria Tanca Vincenzo Adamo Evaristo Maiello Roberto Sabbatini Alessandra Felici Saverio Cinieri Giuseppe Tonini Sergio Bracarda |
| author_facet |
Daniele Santini Giuseppe Procopio Camillo Porta Toni Ibrahim Sandro Barni Calogero Mazzara Andrea Fontana Alfredo Berruti Rossana Berardi Bruno Vincenzi Cinzia Ortega Davide Ottaviani Giacomo Carteni Gaetano Lanzetta Vladimir Virzì Matteo Santoni Nicola Silvestris Maria Antonietta Satolli Elena Collovà Antonio Russo Giuseppe Badalamenti Stefano Luzi Fedeli Francesca Maria Tanca Vincenzo Adamo Evaristo Maiello Roberto Sabbatini Alessandra Felici Saverio Cinieri Giuseppe Tonini Sergio Bracarda |
| author_sort |
Daniele Santini |
| title |
Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. |
| title_short |
Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. |
| title_full |
Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. |
| title_fullStr |
Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. |
| title_full_unstemmed |
Natural history of malignant bone disease in renal cancer: final results of an Italian bone metastasis survey. |
| title_sort |
natural history of malignant bone disease in renal cancer: final results of an italian bone metastasis survey. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/89f1cff242564bc3a6ef30e3f7975439 |
| work_keys_str_mv |
AT danielesantini naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT giuseppeprocopio naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT camilloporta naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT toniibrahim naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT sandrobarni naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT calogeromazzara naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT andreafontana naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT alfredoberruti naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT rossanaberardi naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT brunovincenzi naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT cinziaortega naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT davideottaviani naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT giacomocarteni naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT gaetanolanzetta naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT vladimirvirzi naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT matteosantoni naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT nicolasilvestris naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT mariaantoniettasatolli naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT elenacollova naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT antoniorusso naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT giuseppebadalamenti naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT stefanoluzifedeli naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT francescamariatanca naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT vincenzoadamo naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT evaristomaiello naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT robertosabbatini naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT alessandrafelici naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT saveriocinieri naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT giuseppetonini naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey AT sergiobracarda naturalhistoryofmalignantbonediseaseinrenalcancerfinalresultsofanitalianbonemetastasissurvey |
| _version_ |
1718421513379512320 |