Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression

Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene expression. This raises the question of how the s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Katarzyna M. Grochowska, Julia Bär, Guilherme M. Gomes, Michael R. Kreutz, Anna Karpova
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	Jacob/NSMF CREB NMDAR nuclear localization signal (NLS) importin-α1 synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/89f3917176054208a268f29737d840f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:89f3917176054208a268f29737d840f6
record_format	dspace
spelling	oai:doaj.org-article:89f3917176054208a268f29737d840f62021-12-01T07:18:56ZJacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression1663-356310.3389/fnsyn.2021.787494https://doaj.org/article/89f3917176054208a268f29737d840f62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnsyn.2021.787494/fullhttps://doaj.org/toc/1663-3563Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene expression. This raises the question of how the spatio-temporal integration of synaptic inputs is accomplished at the genomic level and which molecular mechanisms are involved. Protein transport from synapse to nucleus has been shown in several studies and has the potential to encode synaptic signals at the site of origin and decode them in the nucleus. In this review, we summarize the knowledge about the properties of the synapto-nuclear messenger protein Jacob with special emphasis on a putative role in hippocampal neuronal plasticity. We will elaborate on the interactome of Jacob, the signals that control synapto-nuclear trafficking, the mechanisms of transport, and the potential nuclear function. In addition, we will address the organization of the Jacob/NSMF gene, its origin and we will summarize the evidence for the existence of splice isoforms and their expression pattern.Katarzyna M. GrochowskaKatarzyna M. GrochowskaJulia BärJulia BärJulia BärGuilherme M. GomesGuilherme M. GomesMichael R. KreutzMichael R. KreutzMichael R. KreutzMichael R. KreutzAnna KarpovaAnna KarpovaFrontiers Media S.A.articleJacob/NSMFCREBNMDARnuclear localization signal (NLS)importin-α1synaptic plasticityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Synaptic Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Jacob/NSMF CREB NMDAR nuclear localization signal (NLS) importin-α1 synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Jacob/NSMF CREB NMDAR nuclear localization signal (NLS) importin-α1 synaptic plasticity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Katarzyna M. Grochowska Katarzyna M. Grochowska Julia Bär Julia Bär Julia Bär Guilherme M. Gomes Guilherme M. Gomes Michael R. Kreutz Michael R. Kreutz Michael R. Kreutz Michael R. Kreutz Anna Karpova Anna Karpova Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
description	Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of spine synapses receiving excitatory input. Synaptic signals not only act locally but are also conveyed to the nucleus of the postsynaptic neuron to regulate gene expression. This raises the question of how the spatio-temporal integration of synaptic inputs is accomplished at the genomic level and which molecular mechanisms are involved. Protein transport from synapse to nucleus has been shown in several studies and has the potential to encode synaptic signals at the site of origin and decode them in the nucleus. In this review, we summarize the knowledge about the properties of the synapto-nuclear messenger protein Jacob with special emphasis on a putative role in hippocampal neuronal plasticity. We will elaborate on the interactome of Jacob, the signals that control synapto-nuclear trafficking, the mechanisms of transport, and the potential nuclear function. In addition, we will address the organization of the Jacob/NSMF gene, its origin and we will summarize the evidence for the existence of splice isoforms and their expression pattern.
format	article
author	Katarzyna M. Grochowska Katarzyna M. Grochowska Julia Bär Julia Bär Julia Bär Guilherme M. Gomes Guilherme M. Gomes Michael R. Kreutz Michael R. Kreutz Michael R. Kreutz Michael R. Kreutz Anna Karpova Anna Karpova
author_facet	Katarzyna M. Grochowska Katarzyna M. Grochowska Julia Bär Julia Bär Julia Bär Guilherme M. Gomes Guilherme M. Gomes Michael R. Kreutz Michael R. Kreutz Michael R. Kreutz Michael R. Kreutz Anna Karpova Anna Karpova
author_sort	Katarzyna M. Grochowska
title	Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
title_short	Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
title_full	Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
title_fullStr	Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
title_full_unstemmed	Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression
title_sort	jacob, a synapto-nuclear protein messenger linking n-methyl-d-aspartate receptor activation to nuclear gene expression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/89f3917176054208a268f29737d840f6
work_keys_str_mv	AT katarzynamgrochowska jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT katarzynamgrochowska jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT juliabar jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT juliabar jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT juliabar jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT guilhermemgomes jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT guilhermemgomes jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT michaelrkreutz jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT michaelrkreutz jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT michaelrkreutz jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT michaelrkreutz jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT annakarpova jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression AT annakarpova jacobasynaptonuclearproteinmessengerlinkingnmethyldaspartatereceptoractivationtonucleargeneexpression
_version_	1718405424192946176

Jacob, a Synapto-Nuclear Protein Messenger Linking N-methyl-D-aspartate Receptor Activation to Nuclear Gene Expression

Ejemplares similares