A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia

SARS-CoV-2, which originated in China in late 2019, has spread rapidly resulting in a global pandemic. Multiple vaccines have been developed to help prevent COVID-19 infection. Similar to other vaccines, common side effects including fever, fatigue, myalgias have occurred; however, episodes of more...

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Autores principales:	Abhinandan Chittal, Shiavax Rao, Pallavi Lakra, Natalia Nacu, Christopher Haas
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	vaccine-induced thrombotic thrombocytopenia vitt hit moderna vaccine thrombocytopenia Internal medicine RC31-1245
Acceso en línea:	https://doaj.org/article/89f4a166a9ba4a28a244b72dc4776d3a
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spelling	oai:doaj.org-article:89f4a166a9ba4a28a244b72dc4776d3a2021-11-17T14:21:57ZA Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia2000-966610.1080/20009666.2021.1980966https://doaj.org/article/89f4a166a9ba4a28a244b72dc4776d3a2021-11-01T00:00:00Zhttp://dx.doi.org/10.1080/20009666.2021.1980966https://doaj.org/toc/2000-9666SARS-CoV-2, which originated in China in late 2019, has spread rapidly resulting in a global pandemic. Multiple vaccines have been developed to help prevent COVID-19 infection. Similar to other vaccines, common side effects including fever, fatigue, myalgias have occurred; however, episodes of more serious side effects have been noted. One such potentially serious sequalae is vaccine-induced thrombocytopenia (VITT), an autoimmune-mediated phenomenon hypothesized to occur due to molecular mimicry and the production of platelet PF4 antibodies, ultimately leading to thrombocytopenia and easy bruising. In this report, we present the case of a 34-year-old, otherwise, healthy female who presented with easy bruising and thrombocytopenia following completion of the two-dose Moderna COVID-19 vaccine, suspicious for a diagnosis of VITT. The patient was managed conservatively with steroids. Steroids and intravenous immune globulin therapy have been reported in the literature. This report highlights that VITT should be considered in the differential diagnosis for patient presenting with increased bruising in the setting of recent COVID-19 vaccine administration, and furthermore highlights the diagnostic workup and management options for such patients.Abhinandan ChittalShiavax RaoPallavi LakraNatalia NacuChristopher HaasTaylor & Francis Grouparticlevaccine-induced thrombotic thrombocytopeniavitthitmoderna vaccinethrombocytopeniaInternal medicineRC31-1245ENJournal of Community Hospital Internal Medicine Perspectives, Vol 11, Iss 6, Pp 776-778 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vaccine-induced thrombotic thrombocytopenia vitt hit moderna vaccine thrombocytopenia Internal medicine RC31-1245
spellingShingle	vaccine-induced thrombotic thrombocytopenia vitt hit moderna vaccine thrombocytopenia Internal medicine RC31-1245 Abhinandan Chittal Shiavax Rao Pallavi Lakra Natalia Nacu Christopher Haas A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia
description	SARS-CoV-2, which originated in China in late 2019, has spread rapidly resulting in a global pandemic. Multiple vaccines have been developed to help prevent COVID-19 infection. Similar to other vaccines, common side effects including fever, fatigue, myalgias have occurred; however, episodes of more serious side effects have been noted. One such potentially serious sequalae is vaccine-induced thrombocytopenia (VITT), an autoimmune-mediated phenomenon hypothesized to occur due to molecular mimicry and the production of platelet PF4 antibodies, ultimately leading to thrombocytopenia and easy bruising. In this report, we present the case of a 34-year-old, otherwise, healthy female who presented with easy bruising and thrombocytopenia following completion of the two-dose Moderna COVID-19 vaccine, suspicious for a diagnosis of VITT. The patient was managed conservatively with steroids. Steroids and intravenous immune globulin therapy have been reported in the literature. This report highlights that VITT should be considered in the differential diagnosis for patient presenting with increased bruising in the setting of recent COVID-19 vaccine administration, and furthermore highlights the diagnostic workup and management options for such patients.
format	article
author	Abhinandan Chittal Shiavax Rao Pallavi Lakra Natalia Nacu Christopher Haas
author_facet	Abhinandan Chittal Shiavax Rao Pallavi Lakra Natalia Nacu Christopher Haas
author_sort	Abhinandan Chittal
title	A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia
title_short	A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia
title_full	A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia
title_fullStr	A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia
title_full_unstemmed	A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia
title_sort	case of covid-19 vaccine-induced thrombotic thrombocytopenia
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/89f4a166a9ba4a28a244b72dc4776d3a
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A Case of COVID-19 Vaccine-Induced Thrombotic Thrombocytopenia

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