Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats

The gut microbiota consists of a community of microorganisms that inhabit the large intestine. These microbes play important roles in maintaining gut barrier integrity, inflammation, lipid and carbohydrate metabolism, immunity, and protection against pathogens. However, recent studies have shown tha...

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Autores principales:	Ali Khalaf Al Khalaf, Abdulrasheed O. Abdulrahman, Mohammed Kaleem, Suza Mohammad Nur, Amer H. Asseri, Hani Choudhry, Mohammad Imran Khan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	gut microbiota polyphenols urolithins rats metabolism diseases Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/89f51d8345f046a0a734fefaac42b7cc
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spelling	oai:doaj.org-article:89f51d8345f046a0a734fefaac42b7cc2021-11-25T18:34:59ZComparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats10.3390/nu131138852072-6643https://doaj.org/article/89f51d8345f046a0a734fefaac42b7cc2021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3885https://doaj.org/toc/2072-6643The gut microbiota consists of a community of microorganisms that inhabit the large intestine. These microbes play important roles in maintaining gut barrier integrity, inflammation, lipid and carbohydrate metabolism, immunity, and protection against pathogens. However, recent studies have shown that dysfunction in the gut microbiota composition can lead to the development of several diseases. Urolithin A has recently been approved as a functional food ingredient. In this study, we examined the potentials of urolithin A (Uro-A) and B (Uro-B) in improving metabolic functions and their impact on gut microbiota composition under a metabolically unchallenged state in normal rats. Male Wistar rats (<i>n</i> = 18) were randomly segregated into three groups, with Group 1 serving as the control group. Groups 2 and 3 were administered with 2.5 mg/kg Uro-A and Uro-B, respectively, for four weeks. Our results showed that both Uro-A and B improved liver and kidney functions without affecting body weight. Metagenomic analysis revealed that both Uro-A and B induced the growth of Akkermansia. However, Uro-A decreased species diversity and microbial richness and negatively impacted the composition of pathogenic microbes in normal rats. Taken together, this study showed the differential impacts of Uro-A and B on the gut microbiota composition in normal rats and would thus serve as a guide in the choice of these metabolites as a functional food ingredient or prebiotic.Ali Khalaf Al KhalafAbdulrasheed O. AbdulrahmanMohammed KaleemSuza Mohammad NurAmer H. AsseriHani ChoudhryMohammad Imran KhanMDPI AGarticlegut microbiotapolyphenolsurolithinsratsmetabolismdiseasesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3885, p 3885 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut microbiota polyphenols urolithins rats metabolism diseases Nutrition. Foods and food supply TX341-641
spellingShingle	gut microbiota polyphenols urolithins rats metabolism diseases Nutrition. Foods and food supply TX341-641 Ali Khalaf Al Khalaf Abdulrasheed O. Abdulrahman Mohammed Kaleem Suza Mohammad Nur Amer H. Asseri Hani Choudhry Mohammad Imran Khan Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats
description	The gut microbiota consists of a community of microorganisms that inhabit the large intestine. These microbes play important roles in maintaining gut barrier integrity, inflammation, lipid and carbohydrate metabolism, immunity, and protection against pathogens. However, recent studies have shown that dysfunction in the gut microbiota composition can lead to the development of several diseases. Urolithin A has recently been approved as a functional food ingredient. In this study, we examined the potentials of urolithin A (Uro-A) and B (Uro-B) in improving metabolic functions and their impact on gut microbiota composition under a metabolically unchallenged state in normal rats. Male Wistar rats (<i>n</i> = 18) were randomly segregated into three groups, with Group 1 serving as the control group. Groups 2 and 3 were administered with 2.5 mg/kg Uro-A and Uro-B, respectively, for four weeks. Our results showed that both Uro-A and B improved liver and kidney functions without affecting body weight. Metagenomic analysis revealed that both Uro-A and B induced the growth of Akkermansia. However, Uro-A decreased species diversity and microbial richness and negatively impacted the composition of pathogenic microbes in normal rats. Taken together, this study showed the differential impacts of Uro-A and B on the gut microbiota composition in normal rats and would thus serve as a guide in the choice of these metabolites as a functional food ingredient or prebiotic.
format	article
author	Ali Khalaf Al Khalaf Abdulrasheed O. Abdulrahman Mohammed Kaleem Suza Mohammad Nur Amer H. Asseri Hani Choudhry Mohammad Imran Khan
author_facet	Ali Khalaf Al Khalaf Abdulrasheed O. Abdulrahman Mohammed Kaleem Suza Mohammad Nur Amer H. Asseri Hani Choudhry Mohammad Imran Khan
author_sort	Ali Khalaf Al Khalaf
title	Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats
title_short	Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats
title_full	Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats
title_fullStr	Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats
title_full_unstemmed	Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats
title_sort	comparative analysis of the impact of urolithins on the composition of the gut microbiota in normal-diet fed rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/89f51d8345f046a0a734fefaac42b7cc
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Comparative Analysis of the Impact of Urolithins on the Composition of the Gut Microbiota in Normal-Diet Fed Rats

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