An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study
The melanocortin-4 receptor (MC4R) gene harbours one of the strongest susceptibility loci for obesity and obesity-related metabolic consequences. We analysed whether dietary factors may attenuate the associations between <i>MC4R</i> genotypes and obesity and metabolic parameters. In 819...
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oai:doaj.org-article:89fe6d5667f940c2b3aad37fa4f2172a2021-11-11T17:26:42ZAn Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study10.3390/ijms2221120441422-00671661-6596https://doaj.org/article/89fe6d5667f940c2b3aad37fa4f2172a2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/12044https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The melanocortin-4 receptor (MC4R) gene harbours one of the strongest susceptibility loci for obesity and obesity-related metabolic consequences. We analysed whether dietary factors may attenuate the associations between <i>MC4R</i> genotypes and obesity and metabolic parameters. In 819 participants genotyped for common <i>MC4R</i> polymorphisms (rs17782313, rs12970134, rs633265, and rs135034), the anthropometric measurements, body fat content and distribution (visceral and subcutaneous adipose tissue, VAT and SAT, respectively), and blood glucose, insulin, total-, LDL-, HDL-cholesterol, triglycerides concentrations, and daily macronutrient intake were assessed. ANOVA or Kruskal–Wallis tests were used, and multivariate linear regression models were developed. We observed that the CC genotype carriers (rs17782313) presented higher VAT, VAT/SAT ratio, fasting blood glucose and triglyceride concentrations when they were stratified to the upper quantiles of protein intake. An increase in energy derived from proteins was associated with higher BMI (Est. 5.74, R<sup>2</sup> = 0.12), body fat content (Est. 8.44, R<sup>2</sup> = 0.82), VAT (Est. 32.59, R<sup>2</sup> = 0.06), and VAT/SAT ratio (Est. 0.96, R<sup>2</sup> = 0.05). The AA genotype carriers (rs12970134) presented higher BMI, body fat, SAT and VAT, fasting blood glucose, triglycerides and total cholesterol concentrations. An increase in energy derived from proteins by AA carriers was associated with higher VAT (Est.19.95, R<sup>2</sup> = 0.06) and VAT/SAT ratio (Est. 0.64, R<sup>2</sup> = 0.05). Our findings suggest that associations of the common <i>MC4R</i> SNPs with obesity and its metabolic complications may be dependent on the daily dietary intake, which may open new areas for developing personalised diets for preventing and treating obesity and obesity-related comorbidities.Edyta Adamska-PatrunoWitold BauerDorota BielskaJoanna FiedorczukMonika MorozUrszula KrasowskaPrzemyslaw CzajkowskiMarta WielogorskaKatarzyna MaliszewskaSylwia PuckowskaLukasz SzczerbinskiDanuta LipinskaMaria GorskaAdam KretowskiMDPI AGarticle<i>MC4R</i> genegene–diet interactionsobesityobesity-related metabolic complicationsmacronutrients intakeBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12044, p 12044 (2021) |
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EN |
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<i>MC4R</i> gene gene–diet interactions obesity obesity-related metabolic complications macronutrients intake Biology (General) QH301-705.5 Chemistry QD1-999 |
| spellingShingle |
<i>MC4R</i> gene gene–diet interactions obesity obesity-related metabolic complications macronutrients intake Biology (General) QH301-705.5 Chemistry QD1-999 Edyta Adamska-Patruno Witold Bauer Dorota Bielska Joanna Fiedorczuk Monika Moroz Urszula Krasowska Przemyslaw Czajkowski Marta Wielogorska Katarzyna Maliszewska Sylwia Puckowska Lukasz Szczerbinski Danuta Lipinska Maria Gorska Adam Kretowski An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study |
| description |
The melanocortin-4 receptor (MC4R) gene harbours one of the strongest susceptibility loci for obesity and obesity-related metabolic consequences. We analysed whether dietary factors may attenuate the associations between <i>MC4R</i> genotypes and obesity and metabolic parameters. In 819 participants genotyped for common <i>MC4R</i> polymorphisms (rs17782313, rs12970134, rs633265, and rs135034), the anthropometric measurements, body fat content and distribution (visceral and subcutaneous adipose tissue, VAT and SAT, respectively), and blood glucose, insulin, total-, LDL-, HDL-cholesterol, triglycerides concentrations, and daily macronutrient intake were assessed. ANOVA or Kruskal–Wallis tests were used, and multivariate linear regression models were developed. We observed that the CC genotype carriers (rs17782313) presented higher VAT, VAT/SAT ratio, fasting blood glucose and triglyceride concentrations when they were stratified to the upper quantiles of protein intake. An increase in energy derived from proteins was associated with higher BMI (Est. 5.74, R<sup>2</sup> = 0.12), body fat content (Est. 8.44, R<sup>2</sup> = 0.82), VAT (Est. 32.59, R<sup>2</sup> = 0.06), and VAT/SAT ratio (Est. 0.96, R<sup>2</sup> = 0.05). The AA genotype carriers (rs12970134) presented higher BMI, body fat, SAT and VAT, fasting blood glucose, triglycerides and total cholesterol concentrations. An increase in energy derived from proteins by AA carriers was associated with higher VAT (Est.19.95, R<sup>2</sup> = 0.06) and VAT/SAT ratio (Est. 0.64, R<sup>2</sup> = 0.05). Our findings suggest that associations of the common <i>MC4R</i> SNPs with obesity and its metabolic complications may be dependent on the daily dietary intake, which may open new areas for developing personalised diets for preventing and treating obesity and obesity-related comorbidities. |
| format |
article |
| author |
Edyta Adamska-Patruno Witold Bauer Dorota Bielska Joanna Fiedorczuk Monika Moroz Urszula Krasowska Przemyslaw Czajkowski Marta Wielogorska Katarzyna Maliszewska Sylwia Puckowska Lukasz Szczerbinski Danuta Lipinska Maria Gorska Adam Kretowski |
| author_facet |
Edyta Adamska-Patruno Witold Bauer Dorota Bielska Joanna Fiedorczuk Monika Moroz Urszula Krasowska Przemyslaw Czajkowski Marta Wielogorska Katarzyna Maliszewska Sylwia Puckowska Lukasz Szczerbinski Danuta Lipinska Maria Gorska Adam Kretowski |
| author_sort |
Edyta Adamska-Patruno |
| title |
An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study |
| title_short |
An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study |
| title_full |
An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study |
| title_fullStr |
An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study |
| title_full_unstemmed |
An Association between Diet and <i>MC4R</i> Genetic Polymorphism, in Relation to Obesity and Metabolic Parameters—A Cross Sectional Population-Based Study |
| title_sort |
association between diet and <i>mc4r</i> genetic polymorphism, in relation to obesity and metabolic parameters—a cross sectional population-based study |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/89fe6d5667f940c2b3aad37fa4f2172a |
| work_keys_str_mv |
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