Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

Abstract We introduce a novel visual-stimuli four-arm maze (ViS4M) equipped with spectrally- and intensity-controlled LED emitters and dynamic grayscale objects that relies on innate exploratory behavior to assess color and contrast vision in mice. Its application to detect visual impairments during...

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Autores principales:	Jean-Philippe Vit, Dieu-Trang Fuchs, Ariel Angel, Aharon Levy, Itschak Lamensdorf, Keith L. Black, Yosef Koronyo, Maya Koronyo-Hamaoui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/89ff2a0f256b4696861860d2b4d3346d
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spelling	oai:doaj.org-article:89ff2a0f256b4696861860d2b4d3346d2021-12-02T15:22:57ZColor and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze10.1038/s41598-021-80988-02045-2322https://doaj.org/article/89ff2a0f256b4696861860d2b4d3346d2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-80988-0https://doaj.org/toc/2045-2322Abstract We introduce a novel visual-stimuli four-arm maze (ViS4M) equipped with spectrally- and intensity-controlled LED emitters and dynamic grayscale objects that relies on innate exploratory behavior to assess color and contrast vision in mice. Its application to detect visual impairments during normal aging and over the course of Alzheimer’s disease (AD) is evaluated in wild-type (WT) and transgenic APPSWE/PS1∆E9 murine models of AD (AD+) across an array of irradiance, chromaticity, and contrast conditions. Substantial color and contrast-mode alternation deficits appear in AD+ mice at an age when hippocampal-based memory and learning is still intact. Profiling of timespan, entries and transition patterns between the different arms uncovers variable AD-associated impairments in contrast sensitivity and color discrimination, reminiscent of tritanomalous defects documented in AD patients. Transition deficits are found in aged WT mice in the absence of alternation decline. Overall, ViS4M is a versatile, controlled device to measure color and contrast-related vision in aged and diseased mice.Jean-Philippe VitDieu-Trang FuchsAriel AngelAharon LevyItschak LamensdorfKeith L. BlackYosef KoronyoMaya Koronyo-HamaouiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean-Philippe Vit Dieu-Trang Fuchs Ariel Angel Aharon Levy Itschak Lamensdorf Keith L. Black Yosef Koronyo Maya Koronyo-Hamaoui Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze
description	Abstract We introduce a novel visual-stimuli four-arm maze (ViS4M) equipped with spectrally- and intensity-controlled LED emitters and dynamic grayscale objects that relies on innate exploratory behavior to assess color and contrast vision in mice. Its application to detect visual impairments during normal aging and over the course of Alzheimer’s disease (AD) is evaluated in wild-type (WT) and transgenic APPSWE/PS1∆E9 murine models of AD (AD+) across an array of irradiance, chromaticity, and contrast conditions. Substantial color and contrast-mode alternation deficits appear in AD+ mice at an age when hippocampal-based memory and learning is still intact. Profiling of timespan, entries and transition patterns between the different arms uncovers variable AD-associated impairments in contrast sensitivity and color discrimination, reminiscent of tritanomalous defects documented in AD patients. Transition deficits are found in aged WT mice in the absence of alternation decline. Overall, ViS4M is a versatile, controlled device to measure color and contrast-related vision in aged and diseased mice.
format	article
author	Jean-Philippe Vit Dieu-Trang Fuchs Ariel Angel Aharon Levy Itschak Lamensdorf Keith L. Black Yosef Koronyo Maya Koronyo-Hamaoui
author_facet	Jean-Philippe Vit Dieu-Trang Fuchs Ariel Angel Aharon Levy Itschak Lamensdorf Keith L. Black Yosef Koronyo Maya Koronyo-Hamaoui
author_sort	Jean-Philippe Vit
title	Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze
title_short	Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze
title_full	Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze
title_fullStr	Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze
title_full_unstemmed	Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze
title_sort	color and contrast vision in mouse models of aging and alzheimer’s disease using a novel visual-stimuli four-arm maze
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/89ff2a0f256b4696861860d2b4d3346d
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Color and contrast vision in mouse models of aging and Alzheimer’s disease using a novel visual-stimuli four-arm maze

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