Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process

The aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical te...

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Autores principales:	V. E. Khitrikheev, B. N. Garmaev, M. I. Balkhaev, L. V. Khibkhenov, S. P. Khankhasykov, I. G. Nikolaeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	pentaphylloides fruticosa l. sprouts liniment ointment wound process Science Q
Acceso en línea:	https://doaj.org/article/8a00da0fc6ea4410bd1c22838da445eb
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spelling	oai:doaj.org-article:8a00da0fc6ea4410bd1c22838da445eb2021-11-23T06:14:36ZInfluence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process2541-94202587-959610.12737/23408https://doaj.org/article/8a00da0fc6ea4410bd1c22838da445eb2016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/294https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical technology. Experiments were carried out on white male Wistar rats. The skin injury was simulated by inflicting planar wounds 2.0 x 2.0 cm in size. The 5%-liniment and 5% ointment from P. fruticosa were put on the wounds of the first and second experimental groups respectively. In the third group the wounds were treated with glycerin-vaseline ointment. Bioptate of the wound surface was taken on the 7th, 14th and 21st day. Histological preparations were studied using standard methods. Cell elements of the first group animals were displayed as fibroblasts and fibrocytes; it was noted high level of collagen organization that testified the effective staging of the wound process in this case. The amount of fibrocytes and fibroblasts and ratio between juvenile and mature forms of collagen-producing cells vary in the first and second groups. Biopsy material obtained from the animals of the third group only on the 21st day corresponded to the picture observed in animals of the 1st group on the 14th day. The findings of the study verify that the use of the product obtained on NanoDeBee device provides the earlier forming of the scar as compared with the ointment developed using pharmaceutical technology.V. E. KhitrikheevB. N. GarmaevM. I. BalkhaevL. V. KhibkhenovS. P. KhankhasykovI. G. NikolaevaScientific Сentre for Family Health and Human Reproduction Problemsarticlepentaphylloides fruticosa l. sproutslinimentointmentwound processScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 129-132 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	pentaphylloides fruticosa l. sprouts liniment ointment wound process Science Q
spellingShingle	pentaphylloides fruticosa l. sprouts liniment ointment wound process Science Q V. E. Khitrikheev B. N. Garmaev M. I. Balkhaev L. V. Khibkhenov S. P. Khankhasykov I. G. Nikolaeva Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
description	The aim of the work was to estimate a wound-healing effect of soft drug products from the Pentaphylloides fruticosa L. shoots on the model of planar skin-fascial wound. The liniment was developed with the use of the NanoDeBee 30 device and the ointment was developed with the use of pharmaceutical technology. Experiments were carried out on white male Wistar rats. The skin injury was simulated by inflicting planar wounds 2.0 x 2.0 cm in size. The 5%-liniment and 5% ointment from P. fruticosa were put on the wounds of the first and second experimental groups respectively. In the third group the wounds were treated with glycerin-vaseline ointment. Bioptate of the wound surface was taken on the 7th, 14th and 21st day. Histological preparations were studied using standard methods. Cell elements of the first group animals were displayed as fibroblasts and fibrocytes; it was noted high level of collagen organization that testified the effective staging of the wound process in this case. The amount of fibrocytes and fibroblasts and ratio between juvenile and mature forms of collagen-producing cells vary in the first and second groups. Biopsy material obtained from the animals of the third group only on the 21st day corresponded to the picture observed in animals of the 1st group on the 14th day. The findings of the study verify that the use of the product obtained on NanoDeBee device provides the earlier forming of the scar as compared with the ointment developed using pharmaceutical technology.
format	article
author	V. E. Khitrikheev B. N. Garmaev M. I. Balkhaev L. V. Khibkhenov S. P. Khankhasykov I. G. Nikolaeva
author_facet	V. E. Khitrikheev B. N. Garmaev M. I. Balkhaev L. V. Khibkhenov S. P. Khankhasykov I. G. Nikolaeva
author_sort	V. E. Khitrikheev
title	Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
title_short	Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
title_full	Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
title_fullStr	Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
title_full_unstemmed	Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process
title_sort	influence of soft finished pharmaproducts based on pentaphylloides fruticosa l. on the course of wound process
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/8a00da0fc6ea4410bd1c22838da445eb
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Influence of soft finished pharmaproducts based on Pentaphylloides fruticosa l. on the course of wound process

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