Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation

Cathelicidins are antimicrobial peptides that eliminate pathogens and contribute to the innate immune response. Here the authors show that neutrophil-derived LL-37/CRAMP induces platelet activation and promotes arterial thrombosis and thrombo-inflammation.

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Autores principales: Joachim Pircher, Thomas Czermak, Andreas Ehrlich, Clemens Eberle, Erik Gaitzsch, Andreas Margraf, Jochen Grommes, Prakash Saha, Anna Titova, Hellen Ishikawa-Ankerhold, Konstantin Stark, Tobias Petzold, Thomas Stocker, Ludwig T Weckbach, Julia Novotny, Markus Sperandio, Bernhard Nieswandt, Alberto Smith, Hanna Mannell, Barbara Walzog, David Horst, Oliver Soehnlein, Steffen Massberg, Christian Schulz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Q
Acceso en línea:https://doaj.org/article/8a00ffc239a5482690c1439aabca24d4
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spelling oai:doaj.org-article:8a00ffc239a5482690c1439aabca24d42021-12-02T16:49:52ZCathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation10.1038/s41467-018-03925-22041-1723https://doaj.org/article/8a00ffc239a5482690c1439aabca24d42018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03925-2https://doaj.org/toc/2041-1723Cathelicidins are antimicrobial peptides that eliminate pathogens and contribute to the innate immune response. Here the authors show that neutrophil-derived LL-37/CRAMP induces platelet activation and promotes arterial thrombosis and thrombo-inflammation.Joachim PircherThomas CzermakAndreas EhrlichClemens EberleErik GaitzschAndreas MargrafJochen GrommesPrakash SahaAnna TitovaHellen Ishikawa-AnkerholdKonstantin StarkTobias PetzoldThomas StockerLudwig T WeckbachJulia NovotnyMarkus SperandioBernhard NieswandtAlberto SmithHanna MannellBarbara WalzogDavid HorstOliver SoehnleinSteffen MassbergChristian SchulzNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joachim Pircher
Thomas Czermak
Andreas Ehrlich
Clemens Eberle
Erik Gaitzsch
Andreas Margraf
Jochen Grommes
Prakash Saha
Anna Titova
Hellen Ishikawa-Ankerhold
Konstantin Stark
Tobias Petzold
Thomas Stocker
Ludwig T Weckbach
Julia Novotny
Markus Sperandio
Bernhard Nieswandt
Alberto Smith
Hanna Mannell
Barbara Walzog
David Horst
Oliver Soehnlein
Steffen Massberg
Christian Schulz
Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
description Cathelicidins are antimicrobial peptides that eliminate pathogens and contribute to the innate immune response. Here the authors show that neutrophil-derived LL-37/CRAMP induces platelet activation and promotes arterial thrombosis and thrombo-inflammation.
format article
author Joachim Pircher
Thomas Czermak
Andreas Ehrlich
Clemens Eberle
Erik Gaitzsch
Andreas Margraf
Jochen Grommes
Prakash Saha
Anna Titova
Hellen Ishikawa-Ankerhold
Konstantin Stark
Tobias Petzold
Thomas Stocker
Ludwig T Weckbach
Julia Novotny
Markus Sperandio
Bernhard Nieswandt
Alberto Smith
Hanna Mannell
Barbara Walzog
David Horst
Oliver Soehnlein
Steffen Massberg
Christian Schulz
author_facet Joachim Pircher
Thomas Czermak
Andreas Ehrlich
Clemens Eberle
Erik Gaitzsch
Andreas Margraf
Jochen Grommes
Prakash Saha
Anna Titova
Hellen Ishikawa-Ankerhold
Konstantin Stark
Tobias Petzold
Thomas Stocker
Ludwig T Weckbach
Julia Novotny
Markus Sperandio
Bernhard Nieswandt
Alberto Smith
Hanna Mannell
Barbara Walzog
David Horst
Oliver Soehnlein
Steffen Massberg
Christian Schulz
author_sort Joachim Pircher
title Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
title_short Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
title_full Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
title_fullStr Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
title_full_unstemmed Cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
title_sort cathelicidins prime platelets to mediate arterial thrombosis and tissue inflammation
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8a00ffc239a5482690c1439aabca24d4
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