Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 complex to the SNARE complex.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shen Wang, Yun Li, Jihong Gong, Sheng Ye, Xiaofei Yang, Rongguang Zhang, Cong Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a01f2eb682947f79e68e216cc16ded9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a01f2eb682947f79e68e216cc16ded9
record_format	dspace
spelling	oai:doaj.org-article:8a01f2eb682947f79e68e216cc16ded92021-12-02T16:58:18ZMunc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly10.1038/s41467-018-08028-62041-1723https://doaj.org/article/8a01f2eb682947f79e68e216cc16ded92019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08028-6https://doaj.org/toc/2041-1723Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 complex to the SNARE complex.Shen WangYun LiJihong GongSheng YeXiaofei YangRongguang ZhangCong MaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shen Wang Yun Li Jihong Gong Sheng Ye Xiaofei Yang Rongguang Zhang Cong Ma Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
description	Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 complex to the SNARE complex.
format	article
author	Shen Wang Yun Li Jihong Gong Sheng Ye Xiaofei Yang Rongguang Zhang Cong Ma
author_facet	Shen Wang Yun Li Jihong Gong Sheng Ye Xiaofei Yang Rongguang Zhang Cong Ma
author_sort	Shen Wang
title	Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
title_short	Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
title_full	Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
title_fullStr	Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
title_full_unstemmed	Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly
title_sort	munc18 and munc13 serve as a functional template to orchestrate neuronal snare complex assembly
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8a01f2eb682947f79e68e216cc16ded9
work_keys_str_mv	AT shenwang munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly AT yunli munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly AT jihonggong munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly AT shengye munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly AT xiaofeiyang munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly AT rongguangzhang munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly AT congma munc18andmunc13serveasafunctionaltemplatetoorchestrateneuronalsnarecomplexassembly
_version_	1718382341805572096

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Ejemplares similares