Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Munc18 and Munc13 serve as a functional template to orchestrate neuronal SNARE complex assembly

Synaptic exocytosis depends on formation of the SNARE complex but its assembly mechanism is still under debate. Here, the authors identify an interaction between Munc13-1 and synaptobrevin-2 that is critical for the transition of the Munc18-1/syntaxin-1 complex to the SNARE complex.

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Detalles Bibliográficos
Autores principales: Shen Wang, Yun Li, Jihong Gong, Sheng Ye, Xiaofei Yang, Rongguang Zhang, Cong Ma
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/8a01f2eb682947f79e68e216cc16ded9
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