Do We Swallow the Waste From Our Brain?
Ferumoxytol, an iron oxide nanoparticle, was infused into the lateral cerebroventricle of awake rats to follow its movement and clearance from the brain using magnetic resonance imaging. Within minutes the contrast agent could be observed accumulating in the subarachnoid space, nasal cavity, nasal p...
Guardado en:
Autores principales: | , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/8a055046471b4b6bbc94cff8b9144952 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:8a055046471b4b6bbc94cff8b9144952 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:8a055046471b4b6bbc94cff8b91449522021-11-30T12:20:14ZDo We Swallow the Waste From Our Brain?1662-453X10.3389/fnins.2021.763780https://doaj.org/article/8a055046471b4b6bbc94cff8b91449522021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.763780/fullhttps://doaj.org/toc/1662-453XFerumoxytol, an iron oxide nanoparticle, was infused into the lateral cerebroventricle of awake rats to follow its movement and clearance from the brain using magnetic resonance imaging. Within minutes the contrast agent could be observed accumulating in the subarachnoid space, nasal cavity, nasal pharynx, and soft palate at the back of the throat. In a subsequent study fluorescent quantum dots were infused into the brain of rats and within 15 min could be observed in the esophagus using microscopy. These imaging studies clearly show that these large nanoparticle tracers (∼20 nm in diameter) leave the brain through the nasal cavity and end up in the gut. There are numerous studies going back decades reporting the clearance of tracers put directly into the brain. While these studies show the slow accumulation of trace in the blood and lymphatics, they report only accounting for less than 50% of what was originally put in the brain.Joshua LeastonPraveen KulkarniCodi GharagouzlooCodi GharagouzlooJu QiaoNicole BensCraig F. FerrisFrontiers Media S.A.articleferumoxytolnasal pharynxsubarachnoid spacebrain clearanceperivascular spacecanNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
ferumoxytol nasal pharynx subarachnoid space brain clearance perivascular spacecan Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
spellingShingle |
ferumoxytol nasal pharynx subarachnoid space brain clearance perivascular spacecan Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Joshua Leaston Praveen Kulkarni Codi Gharagouzloo Codi Gharagouzloo Ju Qiao Nicole Bens Craig F. Ferris Do We Swallow the Waste From Our Brain? |
description |
Ferumoxytol, an iron oxide nanoparticle, was infused into the lateral cerebroventricle of awake rats to follow its movement and clearance from the brain using magnetic resonance imaging. Within minutes the contrast agent could be observed accumulating in the subarachnoid space, nasal cavity, nasal pharynx, and soft palate at the back of the throat. In a subsequent study fluorescent quantum dots were infused into the brain of rats and within 15 min could be observed in the esophagus using microscopy. These imaging studies clearly show that these large nanoparticle tracers (∼20 nm in diameter) leave the brain through the nasal cavity and end up in the gut. There are numerous studies going back decades reporting the clearance of tracers put directly into the brain. While these studies show the slow accumulation of trace in the blood and lymphatics, they report only accounting for less than 50% of what was originally put in the brain. |
format |
article |
author |
Joshua Leaston Praveen Kulkarni Codi Gharagouzloo Codi Gharagouzloo Ju Qiao Nicole Bens Craig F. Ferris |
author_facet |
Joshua Leaston Praveen Kulkarni Codi Gharagouzloo Codi Gharagouzloo Ju Qiao Nicole Bens Craig F. Ferris |
author_sort |
Joshua Leaston |
title |
Do We Swallow the Waste From Our Brain? |
title_short |
Do We Swallow the Waste From Our Brain? |
title_full |
Do We Swallow the Waste From Our Brain? |
title_fullStr |
Do We Swallow the Waste From Our Brain? |
title_full_unstemmed |
Do We Swallow the Waste From Our Brain? |
title_sort |
do we swallow the waste from our brain? |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/8a055046471b4b6bbc94cff8b9144952 |
work_keys_str_mv |
AT joshualeaston doweswallowthewastefromourbrain AT praveenkulkarni doweswallowthewastefromourbrain AT codigharagouzloo doweswallowthewastefromourbrain AT codigharagouzloo doweswallowthewastefromourbrain AT juqiao doweswallowthewastefromourbrain AT nicolebens doweswallowthewastefromourbrain AT craigfferris doweswallowthewastefromourbrain |
_version_ |
1718406633848045568 |