Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.

<h4>Background and purpose</h4>The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases (MMPs) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia.<h4>Methods</h4>The 781 participants, including 4...

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Autores principales:	Volodymyr Dvornyk, Irina Ponomarenko, Oksana Minyaylo, Evgeny Reshetnikov, Mikhail Churnosov
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a08ff96539148478192b4f4d27b66de
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spelling	oai:doaj.org-article:8a08ff96539148478192b4f4d27b66de2021-12-02T20:14:48ZAssociation of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.1932-620310.1371/journal.pone.0257060https://doaj.org/article/8a08ff96539148478192b4f4d27b66de2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0257060https://doaj.org/toc/1932-6203<h4>Background and purpose</h4>The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases (MMPs) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia.<h4>Methods</h4>The 781 participants, including 434 patients with GU (196 Helicobacter pylori (H. pylori)-positive and 238 H. pylori-negative) and 347 controls (all H. pylori-negative) were recruited for the study. Ten SNPs of the MMP1 (rs1799750), MMP2 (rs243865), MMP3 (rs679620), MMP8 (rs1940475), and MMP9 (rs3918242, rs3918249, rs3787268, rs17576, rs17577, and rs2250889) genes were considered for association with GU using multiple logistic regression. The SNPs associated with GU and loci linked (r2≥0.8) to them were analyzed in silico for their functional assignments.<h4>Results</h4>The SNPs of the MMP9 gene were associated with H. pylori-positive GU: alleles C of rs3918249 (OR = 2.02, pperm = 0.008) and A of rs3787268 (OR = 1.60-1.82, pperm ≤ 0.016), and eight haplotypes of all studied MMP9 gene SNPs (OR = 1.85-2.04, pperm ≤ 0.016) increased risk for H. pylori-positive GU. None of the analyzed SNPs was independently associated with GU and H. pylori-negative GU. Two haplotypes of the MMP9 gene (contributed by rs3918242, rs3918249, rs17576, and rs3787268) increased risk for GU (OR = 1.62-1.65, pperm ≤ 0.006). Six loci of the MMP9 gene, which are associated with H. pylori-positive GU, and 65 SNPs linked to them manifest significant epigenetic effects, have pronounced eQTL (17 genes) and sQTL (6 genes) values.<h4>Conclusion</h4>SNPs of the MMP9 were associated with H. pylori-positive GU but not with H. pylori-negative GU in Caucasians of Central Russia.Volodymyr DvornykIrina PonomarenkoOksana MinyayloEvgeny ReshetnikovMikhail ChurnosovPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0257060 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Volodymyr Dvornyk Irina Ponomarenko Oksana Minyaylo Evgeny Reshetnikov Mikhail Churnosov Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.
description	<h4>Background and purpose</h4>The study analyzed the association of functionally significant polymorphisms of matrix metalloproteinases (MMPs) genes with the development of gastric ulcer (GU) in Caucasians from Central Russia.<h4>Methods</h4>The 781 participants, including 434 patients with GU (196 Helicobacter pylori (H. pylori)-positive and 238 H. pylori-negative) and 347 controls (all H. pylori-negative) were recruited for the study. Ten SNPs of the MMP1 (rs1799750), MMP2 (rs243865), MMP3 (rs679620), MMP8 (rs1940475), and MMP9 (rs3918242, rs3918249, rs3787268, rs17576, rs17577, and rs2250889) genes were considered for association with GU using multiple logistic regression. The SNPs associated with GU and loci linked (r2≥0.8) to them were analyzed in silico for their functional assignments.<h4>Results</h4>The SNPs of the MMP9 gene were associated with H. pylori-positive GU: alleles C of rs3918249 (OR = 2.02, pperm = 0.008) and A of rs3787268 (OR = 1.60-1.82, pperm ≤ 0.016), and eight haplotypes of all studied MMP9 gene SNPs (OR = 1.85-2.04, pperm ≤ 0.016) increased risk for H. pylori-positive GU. None of the analyzed SNPs was independently associated with GU and H. pylori-negative GU. Two haplotypes of the MMP9 gene (contributed by rs3918242, rs3918249, rs17576, and rs3787268) increased risk for GU (OR = 1.62-1.65, pperm ≤ 0.006). Six loci of the MMP9 gene, which are associated with H. pylori-positive GU, and 65 SNPs linked to them manifest significant epigenetic effects, have pronounced eQTL (17 genes) and sQTL (6 genes) values.<h4>Conclusion</h4>SNPs of the MMP9 were associated with H. pylori-positive GU but not with H. pylori-negative GU in Caucasians of Central Russia.
format	article
author	Volodymyr Dvornyk Irina Ponomarenko Oksana Minyaylo Evgeny Reshetnikov Mikhail Churnosov
author_facet	Volodymyr Dvornyk Irina Ponomarenko Oksana Minyaylo Evgeny Reshetnikov Mikhail Churnosov
author_sort	Volodymyr Dvornyk
title	Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.
title_short	Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.
title_full	Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.
title_fullStr	Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.
title_full_unstemmed	Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.
title_sort	association of the functionally significant polymorphisms of the mmp9 gene with h. pylori-positive gastric ulcer in the caucasian population of central russia.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/8a08ff96539148478192b4f4d27b66de
work_keys_str_mv	AT volodymyrdvornyk associationofthefunctionallysignificantpolymorphismsofthemmp9genewithhpyloripositivegastriculcerinthecaucasianpopulationofcentralrussia AT irinaponomarenko associationofthefunctionallysignificantpolymorphismsofthemmp9genewithhpyloripositivegastriculcerinthecaucasianpopulationofcentralrussia AT oksanaminyaylo associationofthefunctionallysignificantpolymorphismsofthemmp9genewithhpyloripositivegastriculcerinthecaucasianpopulationofcentralrussia AT evgenyreshetnikov associationofthefunctionallysignificantpolymorphismsofthemmp9genewithhpyloripositivegastriculcerinthecaucasianpopulationofcentralrussia AT mikhailchurnosov associationofthefunctionallysignificantpolymorphismsofthemmp9genewithhpyloripositivegastriculcerinthecaucasianpopulationofcentralrussia
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Association of the functionally significant polymorphisms of the MMP9 gene with H. pylori-positive gastric ulcer in the Caucasian population of Central Russia.

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