Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus

Shasha Liu,1 Jinxue Wei,2,3 Rongjun Ni,2,3 Tianhao Gao,1 Peiyan Ni,2,3 Liansheng Zhao,2,3 Xiyu Duan,2,3 Xiaohong Ma,2,3 Pak C Sham,4,5 Tao Li1– 3,6 1Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liu S, Wei J, Ni R, Gao T, Ni P, Zhao L, Duan X, Ma X, Sham PC, Li T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	bipolar disorder clockdelta19 mouse valproate mania-like behavior neurotransmitter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8a0a1bf6a64c41d787c019cadf5bd0ae
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a0a1bf6a64c41d787c019cadf5bd0ae
record_format	dspace
spelling	oai:doaj.org-article:8a0a1bf6a64c41d787c019cadf5bd0ae2021-12-02T14:14:59ZValproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus1178-2021https://doaj.org/article/8a0a1bf6a64c41d787c019cadf5bd0ae2021-02-01T00:00:00Zhttps://www.dovepress.com/valproate-reverses-mania-like-behavior-of-clockdelta19-mouse-and-alter-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shasha Liu,1 Jinxue Wei,2,3 Rongjun Ni,2,3 Tianhao Gao,1 Peiyan Ni,2,3 Liansheng Zhao,2,3 Xiyu Duan,2,3 Xiaohong Ma,2,3 Pak C Sham,4,5 Tao Li1– 3,6 1Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China; 2Psychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 3Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 4Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 5State Key Laboratory for Cognitive and Brain Sciences, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou, People’s Republic of ChinaCorrespondence: Tao LiPsychiatric Laboratory of West China Hospital, Sichuan University, 1 Keyuan Si Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail litaohx@scu.edu.cnBackground: Mice with a deletion at exon 19 of the circadian locomotor output cycles Kaput gene (Clockdelta19) exhibit mania-like behavior and have been one of the most common animal models for bipolar disorder (BD). The predictive validity of the Clockdelta19 was investigated via studies using lithium previously. Determination of effects of other mood stabilizers on Clockdelta19 mouse would be helpful for better understanding of the mechanism underlined.Methods: Wildtype (WT) and Clockdelta19 mice were treated with saline (n = 10 for WT and n=10 for Clockdelta19) or valproate (VPA) (n = 10 for WT and n=10 for Clockdelta19) for 10 days. The hyperactivity, anxiety-like behaviors and depression-like behaviors were tested. The concentration of monoamine neurotransmitters and their metabolites in the hippocampus of saline or VPA treated WT and Clockdelta19 mouse (n = 8 for each) were also determined.Results: VPA can reverse hyperactivity, lower level of anxiety-like and depression-like behaviors of the Clockdelta19 mouse. Clockdelta19 mouse exhibited lower levels of serotonin (5-HT) and dopamine (DA) in right hippocampus compared to WT mouse. Chronic VPA treatment did not affect the levels of 5-HT and DA, but can reduce the level of levodopa (L-DOPA) in the right hippocampus of Clockdelta19 mouse.Conclusion: Our results indicated that chronic VPA treatment can reverse the mania-like behaviors of the Clockdelta19 mouse and further consolidate the validity of the Clockdelta19 mouse as a model of BD. Monoamine neurotransmitters and their metabolites in the hippocampus are partly regulated by mutation of the Clock gene or VPA treatment.Keywords: bipolar disorder, Clockdelta19 mouse, valproate, mania-like behavior, neurotransmitterLiu SWei JNi RGao TNi PZhao LDuan XMa XSham PCLi TDove Medical Pressarticlebipolar disorderclockdelta19 mousevalproatemania-like behaviorneurotransmitterNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 471-480 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bipolar disorder clockdelta19 mouse valproate mania-like behavior neurotransmitter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	bipolar disorder clockdelta19 mouse valproate mania-like behavior neurotransmitter Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liu S Wei J Ni R Gao T Ni P Zhao L Duan X Ma X Sham PC Li T Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus
description	Shasha Liu,1 Jinxue Wei,2,3 Rongjun Ni,2,3 Tianhao Gao,1 Peiyan Ni,2,3 Liansheng Zhao,2,3 Xiyu Duan,2,3 Xiaohong Ma,2,3 Pak C Sham,4,5 Tao Li1– 3,6 1Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, People’s Republic of China; 2Psychiatric Laboratory and Mental Health Center, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 3Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 4Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 5State Key Laboratory for Cognitive and Brain Sciences, The University of Hong Kong, Pokfulam, Hong Kong, People’s Republic of China; 6Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangzhou, People’s Republic of ChinaCorrespondence: Tao LiPsychiatric Laboratory of West China Hospital, Sichuan University, 1 Keyuan Si Road, Chengdu, Sichuan, 610041, People’s Republic of ChinaEmail litaohx@scu.edu.cnBackground: Mice with a deletion at exon 19 of the circadian locomotor output cycles Kaput gene (Clockdelta19) exhibit mania-like behavior and have been one of the most common animal models for bipolar disorder (BD). The predictive validity of the Clockdelta19 was investigated via studies using lithium previously. Determination of effects of other mood stabilizers on Clockdelta19 mouse would be helpful for better understanding of the mechanism underlined.Methods: Wildtype (WT) and Clockdelta19 mice were treated with saline (n = 10 for WT and n=10 for Clockdelta19) or valproate (VPA) (n = 10 for WT and n=10 for Clockdelta19) for 10 days. The hyperactivity, anxiety-like behaviors and depression-like behaviors were tested. The concentration of monoamine neurotransmitters and their metabolites in the hippocampus of saline or VPA treated WT and Clockdelta19 mouse (n = 8 for each) were also determined.Results: VPA can reverse hyperactivity, lower level of anxiety-like and depression-like behaviors of the Clockdelta19 mouse. Clockdelta19 mouse exhibited lower levels of serotonin (5-HT) and dopamine (DA) in right hippocampus compared to WT mouse. Chronic VPA treatment did not affect the levels of 5-HT and DA, but can reduce the level of levodopa (L-DOPA) in the right hippocampus of Clockdelta19 mouse.Conclusion: Our results indicated that chronic VPA treatment can reverse the mania-like behaviors of the Clockdelta19 mouse and further consolidate the validity of the Clockdelta19 mouse as a model of BD. Monoamine neurotransmitters and their metabolites in the hippocampus are partly regulated by mutation of the Clock gene or VPA treatment.Keywords: bipolar disorder, Clockdelta19 mouse, valproate, mania-like behavior, neurotransmitter
format	article
author	Liu S Wei J Ni R Gao T Ni P Zhao L Duan X Ma X Sham PC Li T
author_facet	Liu S Wei J Ni R Gao T Ni P Zhao L Duan X Ma X Sham PC Li T
author_sort	Liu S
title	Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus
title_short	Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus
title_full	Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus
title_fullStr	Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus
title_full_unstemmed	Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus
title_sort	valproate reverses mania-like behavior of clockdelta19 mouse and alters monoamine neurotransmitters metabolism in the hippocampus
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8a0a1bf6a64c41d787c019cadf5bd0ae
work_keys_str_mv	AT lius valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT weij valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT nir valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT gaot valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT nip valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT zhaol valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT duanx valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT max valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT shampc valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus AT lit valproatereversesmanialikebehaviorofclockdelta19mouseandaltersmonoamineneurotransmittersmetabolisminthehippocampus
_version_	1718391738398146560

Valproate Reverses Mania-Like Behavior of Clockdelta19 Mouse and Alters Monoamine Neurotransmitters Metabolism in the Hippocampus

Ejemplares similares