Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer

Introduction: In our previous studies it was concluded that the zinc (Zn) level in in human expressed prostatic fluid (EPF) is a first candidate with the role of offering a new, simple, fast, reliable, and non-invasive diagnostic tool for prostate cancer (PCa) screening. However it was unclear how o...

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Autores principales:	Vladimir Zaichick, Sofia Zaichick
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2020
Materias:	prostate cancer bladder cancer expressed prostatic fluid zinc energy-dispersive x-ray fluorescent analysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8a0b5467256b4f20b260e2cdff836c63
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spelling	oai:doaj.org-article:8a0b5467256b4f20b260e2cdff836c632021-12-02T15:37:04ZZinc concentrations in the expressed prostatic fluid of patients with bladder cancer10.5281/zenodo.37862672695-5075https://doaj.org/article/8a0b5467256b4f20b260e2cdff836c632020-07-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3786267https://doaj.org/toc/2695-5075Introduction: In our previous studies it was concluded that the zinc (Zn) level in in human expressed prostatic fluid (EPF) is a first candidate with the role of offering a new, simple, fast, reliable, and non-invasive diagnostic tool for prostate cancer (PCa) screening. However it was unclear how other non-prostatic diseases inherent of the old persons, including heart diseases, atherosclerosis, diabetes, asymptomatic cancer of different localization and some others, impact on a chemical element composition of expressed prostatic fluid. Thus, the purpose of this study was to evaluate whether significant changes in the levels of Zn in EPF exist in patients with bladder cancer (BC). Methods: Prostatic fluid levels of Zn were prospectively evaluated in 17 patients with BC and 51 healthy male inhabitants (control group). Measurements were performed using 109Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis developed by us. Results: Mean value  standard deviation of mean (MSD) for concentration of Zn in the EPF of healthy males and patients with BC was 573202 mg/L and 625±108 mg/L, respectively. Using both parametric Student’s t-test and non-parametric Wilcoxon-Mann-Whitney U-test it was shown that the Zn concentration in the EPF of patients with BC did not differ from that in healthy subjects. Conclusion: Such serious illness as BC did not impact on the Zn concentration in the EPF.Vladimir ZaichickSofia ZaichickEmergency Department of Hospital San Pedro (Logroño, Spain)articleprostate cancerbladder cancerexpressed prostatic fluidzincenergy-dispersive x-ray fluorescent analysisMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 3, Pp 167-171 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer bladder cancer expressed prostatic fluid zinc energy-dispersive x-ray fluorescent analysis Medicine (General) R5-920
spellingShingle	prostate cancer bladder cancer expressed prostatic fluid zinc energy-dispersive x-ray fluorescent analysis Medicine (General) R5-920 Vladimir Zaichick Sofia Zaichick Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
description	Introduction: In our previous studies it was concluded that the zinc (Zn) level in in human expressed prostatic fluid (EPF) is a first candidate with the role of offering a new, simple, fast, reliable, and non-invasive diagnostic tool for prostate cancer (PCa) screening. However it was unclear how other non-prostatic diseases inherent of the old persons, including heart diseases, atherosclerosis, diabetes, asymptomatic cancer of different localization and some others, impact on a chemical element composition of expressed prostatic fluid. Thus, the purpose of this study was to evaluate whether significant changes in the levels of Zn in EPF exist in patients with bladder cancer (BC). Methods: Prostatic fluid levels of Zn were prospectively evaluated in 17 patients with BC and 51 healthy male inhabitants (control group). Measurements were performed using 109Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis developed by us. Results: Mean value  standard deviation of mean (MSD) for concentration of Zn in the EPF of healthy males and patients with BC was 573202 mg/L and 625±108 mg/L, respectively. Using both parametric Student’s t-test and non-parametric Wilcoxon-Mann-Whitney U-test it was shown that the Zn concentration in the EPF of patients with BC did not differ from that in healthy subjects. Conclusion: Such serious illness as BC did not impact on the Zn concentration in the EPF.
format	article
author	Vladimir Zaichick Sofia Zaichick
author_facet	Vladimir Zaichick Sofia Zaichick
author_sort	Vladimir Zaichick
title	Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
title_short	Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
title_full	Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
title_fullStr	Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
title_full_unstemmed	Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
title_sort	zinc concentrations in the expressed prostatic fluid of patients with bladder cancer
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2020
url	https://doaj.org/article/8a0b5467256b4f20b260e2cdff836c63
work_keys_str_mv	AT vladimirzaichick zincconcentrationsintheexpressedprostaticfluidofpatientswithbladdercancer AT sofiazaichick zincconcentrationsintheexpressedprostaticfluidofpatientswithbladdercancer
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Zinc concentrations in the expressed prostatic fluid of patients with bladder cancer

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