Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets

Abstract Neonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is important in treatment strategy selection to categorize the degree of hypoxia ischemia and evaluate dose response. In an asphyxia piglet model with...

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Autores principales:	Tsutomu Mitsuie, Shinji Nakamura, Yinmon Htun, Yasuhiro Nakao, Makoto Arioka, Kosuke Koyano, Aya Morimoto, Takayuki Wakabayashi, Yasuhiro Kuroda, Takashi Kusaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a0b8d00b8a84dd68bd1e66a3599d208
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spelling	oai:doaj.org-article:8a0b8d00b8a84dd68bd1e66a3599d2082021-12-02T18:02:43ZCerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets10.1038/s41598-021-92586-12045-2322https://doaj.org/article/8a0b8d00b8a84dd68bd1e66a3599d2082021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92586-1https://doaj.org/toc/2045-2322Abstract Neonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is important in treatment strategy selection to categorize the degree of hypoxia ischemia and evaluate dose response. In an asphyxia piglet model with histopathological brain injuries that we previously developed, animals survived 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by varying the amount and timing of inspired oxygen in 20 anesthetized piglets. CBV was measured using near-infrared time-resolved spectroscopy before, during, and 6 h after insult. Change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV, but blood pressure did not. Because the decrement in CBV was larger in severe HI, the CBV increment immediately after insult is considered useful for assessing degree of HI insult.Tsutomu MitsuieShinji NakamuraYinmon HtunYasuhiro NakaoMakoto AriokaKosuke KoyanoAya MorimotoTakayuki WakabayashiYasuhiro KurodaTakashi KusakaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tsutomu Mitsuie Shinji Nakamura Yinmon Htun Yasuhiro Nakao Makoto Arioka Kosuke Koyano Aya Morimoto Takayuki Wakabayashi Yasuhiro Kuroda Takashi Kusaka Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
description	Abstract Neonatal hypoxic–ischemic encephalopathy is a notable cause of neonatal death and developmental disabilities. To achieve better outcomes, it is important in treatment strategy selection to categorize the degree of hypoxia ischemia and evaluate dose response. In an asphyxia piglet model with histopathological brain injuries that we previously developed, animals survived 5 days after insult and showed changes in cerebral blood volume (CBV) that reflected the severity of injuries. However, little is known about the relationship between changes in CBV during and after insult. In this study, an HI event was induced by varying the amount and timing of inspired oxygen in 20 anesthetized piglets. CBV was measured using near-infrared time-resolved spectroscopy before, during, and 6 h after insult. Change in CBV was calculated as the difference between the peak CBV value during insult and the value at the end of insult. The decrease in CBV during insult was found to correlate with the increase in CBV within 6 h after insult. Heart rate exhibited a similar tendency to CBV, but blood pressure did not. Because the decrement in CBV was larger in severe HI, the CBV increment immediately after insult is considered useful for assessing degree of HI insult.
format	article
author	Tsutomu Mitsuie Shinji Nakamura Yinmon Htun Yasuhiro Nakao Makoto Arioka Kosuke Koyano Aya Morimoto Takayuki Wakabayashi Yasuhiro Kuroda Takashi Kusaka
author_facet	Tsutomu Mitsuie Shinji Nakamura Yinmon Htun Yasuhiro Nakao Makoto Arioka Kosuke Koyano Aya Morimoto Takayuki Wakabayashi Yasuhiro Kuroda Takashi Kusaka
author_sort	Tsutomu Mitsuie
title	Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
title_short	Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
title_full	Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
title_fullStr	Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
title_full_unstemmed	Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
title_sort	cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a0b8d00b8a84dd68bd1e66a3599d208
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_version_	1718378878932615168

Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic–ischemic insult in newborn piglets

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