Synergetic improvements of sensitivity and specificity of nanowire field effect transistor gene chip by designing neutralized DNA as probe

Abstract Neutral DNA analogs as probes for the detection of target oligomers on the biosensors based on the field-effect transistor (FET) configuration feature advantages in the enhancement of sensitivity and signal-to-noise ratio. Herein, we used phosphate-methylated nucleotides to synthesize two p...

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Autores principales: Wen-Pin Hu, Chih-Chin Tsai, Yuh-Shyong Yang, Hardy Wai-Hong Chan, Wen-Yih Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8a0c489ed7ad487bb2c0347390cea90e
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