Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis

Abstract Low density lipoprotein receptor-related protein 1 (LRP1) C766T polymorphism (rs1799986) has been extensively investigated for Alzheimer’s disease (AD) susceptibility. However, results in different studies have been contradictory. Therefore, we conducted a meta-analysis containing 6455 AD c...

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Autores principales:	Yun Wang, Shengyuan Liu, Jingjing Wang, Jie Zhang, Yaqiong Hua, Hua Li, Huibiao Tan, Bin Kuai, Biao Wang, Sitong Sheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a0c87ff6c754413a7fe6e0a0cc21c2c
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spelling	oai:doaj.org-article:8a0c87ff6c754413a7fe6e0a0cc21c2c2021-12-02T16:06:47ZAssociation between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis10.1038/s41598-017-08335-w2045-2322https://doaj.org/article/8a0c87ff6c754413a7fe6e0a0cc21c2c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08335-whttps://doaj.org/toc/2045-2322Abstract Low density lipoprotein receptor-related protein 1 (LRP1) C766T polymorphism (rs1799986) has been extensively investigated for Alzheimer’s disease (AD) susceptibility. However, results in different studies have been contradictory. Therefore, we conducted a meta-analysis containing 6455 AD cases and 6304 controls from 26 independent case–control studies to determine whether there was an association between the LRP1 C766T polymorphism and AD susceptibility. The combined analysis showed that there was no significant association between LRP1 C766T polymorphism and AD susceptibility (TT + CT versus CC: OR = 0.920, 95% CI = 0.817–1.037, P = 0.172). In subgroup analysis, significant decreased AD susceptibility was found among Asian population in allele model (T versus C: OR = 0.786, 95% CI = 0.635–0.974, P = 0.028) and dominant model (TT + CT versus CC: OR = 0.800, 95% CI = 0.647–0.990, P = 0.040). Moreover, T allele of LRP1 C766T was statistically associated with late onset of AD (LOAD) (T versus C: OR = 0.858, 95% CI = 0.748–0.985, P = 0.029; TT + CT versus CC: OR = 0.871, 95% CI = 0.763–0.994, P = 0.040). In conclusion, our meta-analysis suggested that LRP1 C766T polymorphism was associated with lower risk of AD in Asian, and could reduce LOAD risk especially. Considering some limitations of our meta-analysis, further large-scale studies should be done to reach a more comprehensive understanding.Yun WangShengyuan LiuJingjing WangJie ZhangYaqiong HuaHua LiHuibiao TanBin KuaiBiao WangSitong ShengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yun Wang Shengyuan Liu Jingjing Wang Jie Zhang Yaqiong Hua Hua Li Huibiao Tan Bin Kuai Biao Wang Sitong Sheng Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis
description	Abstract Low density lipoprotein receptor-related protein 1 (LRP1) C766T polymorphism (rs1799986) has been extensively investigated for Alzheimer’s disease (AD) susceptibility. However, results in different studies have been contradictory. Therefore, we conducted a meta-analysis containing 6455 AD cases and 6304 controls from 26 independent case–control studies to determine whether there was an association between the LRP1 C766T polymorphism and AD susceptibility. The combined analysis showed that there was no significant association between LRP1 C766T polymorphism and AD susceptibility (TT + CT versus CC: OR = 0.920, 95% CI = 0.817–1.037, P = 0.172). In subgroup analysis, significant decreased AD susceptibility was found among Asian population in allele model (T versus C: OR = 0.786, 95% CI = 0.635–0.974, P = 0.028) and dominant model (TT + CT versus CC: OR = 0.800, 95% CI = 0.647–0.990, P = 0.040). Moreover, T allele of LRP1 C766T was statistically associated with late onset of AD (LOAD) (T versus C: OR = 0.858, 95% CI = 0.748–0.985, P = 0.029; TT + CT versus CC: OR = 0.871, 95% CI = 0.763–0.994, P = 0.040). In conclusion, our meta-analysis suggested that LRP1 C766T polymorphism was associated with lower risk of AD in Asian, and could reduce LOAD risk especially. Considering some limitations of our meta-analysis, further large-scale studies should be done to reach a more comprehensive understanding.
format	article
author	Yun Wang Shengyuan Liu Jingjing Wang Jie Zhang Yaqiong Hua Hua Li Huibiao Tan Bin Kuai Biao Wang Sitong Sheng
author_facet	Yun Wang Shengyuan Liu Jingjing Wang Jie Zhang Yaqiong Hua Hua Li Huibiao Tan Bin Kuai Biao Wang Sitong Sheng
author_sort	Yun Wang
title	Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis
title_short	Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis
title_full	Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis
title_fullStr	Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis
title_full_unstemmed	Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis
title_sort	association between lrp1 c766t polymorphism and alzheimer’s disease susceptibility: a meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a0c87ff6c754413a7fe6e0a0cc21c2c
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Association between LRP1 C766T polymorphism and Alzheimer’s disease susceptibility: a meta-analysis

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