Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor

Abstract In this work we study the assisted translocation of a polymer across a membrane nanopore, inside which a molecular motor exerts a force fuelled by the hydrolysis of ATP molecules. In our model the motor switches to its active state for a fixed amount of time, while it waits for an ATP molec...

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Autores principales:	A. Fiasconaro, J. J. Mazo, F. Falo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a0d805be2f146639b2b59c95bd69db2
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spelling	oai:doaj.org-article:8a0d805be2f146639b2b59c95bd69db22021-12-02T16:06:29ZActive translocation of a semiflexible polymer assisted by an ATP-based molecular motor10.1038/s41598-017-04364-72045-2322https://doaj.org/article/8a0d805be2f146639b2b59c95bd69db22017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04364-7https://doaj.org/toc/2045-2322Abstract In this work we study the assisted translocation of a polymer across a membrane nanopore, inside which a molecular motor exerts a force fuelled by the hydrolysis of ATP molecules. In our model the motor switches to its active state for a fixed amount of time, while it waits for an ATP molecule which triggers the motor, during an exponentially distributed time lapse. The polymer is modelled as a beads-springs chain with both excluded volume and bending contributions, and moves in a stochastic three dimensional environment modelled with a Langevin dynamics at a fixed temperature. The resulting dynamics shows a Michaelis-Menten translocation velocity that depends on the chain flexibility. The scaling behavior of the mean translocation time with the polymer length for different bending values is also investigated.A. FiasconaroJ. J. MazoF. FaloNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Fiasconaro J. J. Mazo F. Falo Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
description	Abstract In this work we study the assisted translocation of a polymer across a membrane nanopore, inside which a molecular motor exerts a force fuelled by the hydrolysis of ATP molecules. In our model the motor switches to its active state for a fixed amount of time, while it waits for an ATP molecule which triggers the motor, during an exponentially distributed time lapse. The polymer is modelled as a beads-springs chain with both excluded volume and bending contributions, and moves in a stochastic three dimensional environment modelled with a Langevin dynamics at a fixed temperature. The resulting dynamics shows a Michaelis-Menten translocation velocity that depends on the chain flexibility. The scaling behavior of the mean translocation time with the polymer length for different bending values is also investigated.
format	article
author	A. Fiasconaro J. J. Mazo F. Falo
author_facet	A. Fiasconaro J. J. Mazo F. Falo
author_sort	A. Fiasconaro
title	Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
title_short	Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
title_full	Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
title_fullStr	Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
title_full_unstemmed	Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor
title_sort	active translocation of a semiflexible polymer assisted by an atp-based molecular motor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a0d805be2f146639b2b59c95bd69db2
work_keys_str_mv	AT afiasconaro activetranslocationofasemiflexiblepolymerassistedbyanatpbasedmolecularmotor AT jjmazo activetranslocationofasemiflexiblepolymerassistedbyanatpbasedmolecularmotor AT ffalo activetranslocationofasemiflexiblepolymerassistedbyanatpbasedmolecularmotor
_version_	1718384974260862976

Active translocation of a semiflexible polymer assisted by an ATP-based molecular motor

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