IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY

Two-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and...

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Autores principales:	N. V. Korneva, A. A. Starshinova, Yu. E. Ovchinnikova, E. I. Potapenko, O. A. Yakunova, I. F. Dovgalyuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tuberculosis children immunity diaskintest® quantiferon tb-gold Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8a0d9bef62d74b55ab506a9a883a9708
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spelling	oai:doaj.org-article:8a0d9bef62d74b55ab506a9a883a97082021-11-18T08:03:44ZIMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY1563-06252313-741X10.15789/1563-0625-2014-5-425-430https://doaj.org/article/8a0d9bef62d74b55ab506a9a883a97082014-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/728https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XTwo-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and immunologic assessment. All the patients were examined by DIASKINTEST® (DST) and QuantiferonTB Gold (QFT-G). They were divided into 2 groups, as based on laboratory data, as follows: group I (n= 63), patients with negative DST and QFT-G results; group II (n = 148), with positive results of specific tests. The study was aimed for intergroup comparisons of immune response markers. Positive results of DST and QFT-G suggested clinical activity of tuberculosis infection and are associated with high scores of tuberculin skin test (TST); increased cytokine levels (TNFα, IL-2, IFNγ), higher percentage of CD3+, CD4+ и CD95+ cells, elevated levels of specific IgG antibodies (anda TB ELISA); high titers of complement fixation test for mycobacteria, and activation of neutrophils. Positive results of DST and QFT-G in the patients are more often associated with active infection.N. V. KornevaA. A. StarshinovaYu. E. OvchinnikovaE. I. PotapenkoO. A. YakunovaI. F. DovgalyukSPb RAACIarticletuberculosischildrenimmunitydiaskintest®quantiferon tb-goldImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 5, Pp 425-430 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis children immunity diaskintest® quantiferon tb-gold Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis children immunity diaskintest® quantiferon tb-gold Immunologic diseases. Allergy RC581-607 N. V. Korneva A. A. Starshinova Yu. E. Ovchinnikova E. I. Potapenko O. A. Yakunova I. F. Dovgalyuk IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
description	Two-hundred-eleven patients 3 to 14 years old (mean age 8.60±0.22 years) were observed and clinically evaluated at the Department of Pediatric Phthisiopulmonology, St.Petersburg Institute of Phthisiopulmonology during 2011-2013. The diagnostic protocol included: clinical data, X-rays diagnostics and immunologic assessment. All the patients were examined by DIASKINTEST® (DST) and QuantiferonTB Gold (QFT-G). They were divided into 2 groups, as based on laboratory data, as follows: group I (n= 63), patients with negative DST and QFT-G results; group II (n = 148), with positive results of specific tests. The study was aimed for intergroup comparisons of immune response markers. Positive results of DST and QFT-G suggested clinical activity of tuberculosis infection and are associated with high scores of tuberculin skin test (TST); increased cytokine levels (TNFα, IL-2, IFNγ), higher percentage of CD3+, CD4+ и CD95+ cells, elevated levels of specific IgG antibodies (anda TB ELISA); high titers of complement fixation test for mycobacteria, and activation of neutrophils. Positive results of DST and QFT-G in the patients are more often associated with active infection.
format	article
author	N. V. Korneva A. A. Starshinova Yu. E. Ovchinnikova E. I. Potapenko O. A. Yakunova I. F. Dovgalyuk
author_facet	N. V. Korneva A. A. Starshinova Yu. E. Ovchinnikova E. I. Potapenko O. A. Yakunova I. F. Dovgalyuk
author_sort	N. V. Korneva
title	IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
title_short	IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
title_full	IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
title_fullStr	IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
title_full_unstemmed	IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY
title_sort	immunologic parameters in children with tuberculosis infection of different activity
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8a0d9bef62d74b55ab506a9a883a9708
work_keys_str_mv	AT nvkorneva immunologicparametersinchildrenwithtuberculosisinfectionofdifferentactivity AT aastarshinova immunologicparametersinchildrenwithtuberculosisinfectionofdifferentactivity AT yueovchinnikova immunologicparametersinchildrenwithtuberculosisinfectionofdifferentactivity AT eipotapenko immunologicparametersinchildrenwithtuberculosisinfectionofdifferentactivity AT oayakunova immunologicparametersinchildrenwithtuberculosisinfectionofdifferentactivity AT ifdovgalyuk immunologicparametersinchildrenwithtuberculosisinfectionofdifferentactivity
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IMMUNOLOGIC PARAMETERS IN CHILDREN WITH TUBERCULOSIS INFECTION OF DIFFERENT ACTIVITY

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