The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women

Abstract Taurine is a sulfur-containing amino acid that plays an important role in glucose homeostasis. However, it remains unknown whether the plasma concentration of taurine affects the risk of later gestational diabetes mellitus (GDM) development. We recruited 398 singleton-pregnancy women and fo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Peng Ju Liu, Yanping Liu, Liangkun Ma, Lihong Liu, Ting Hu, Zhuoling An, Ai Min Yao, Liang Yu Xia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a0ea151b9174466be110d343c500eb6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a0ea151b9174466be110d343c500eb6
record_format	dspace
spelling	oai:doaj.org-article:8a0ea151b9174466be110d343c500eb62021-12-02T15:51:11ZThe relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women10.1038/s41598-021-87178-y2045-2322https://doaj.org/article/8a0ea151b9174466be110d343c500eb62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87178-yhttps://doaj.org/toc/2045-2322Abstract Taurine is a sulfur-containing amino acid that plays an important role in glucose homeostasis. However, it remains unknown whether the plasma concentration of taurine affects the risk of later gestational diabetes mellitus (GDM) development. We recruited 398 singleton-pregnancy women and followed up them during the course of pregnancy. We measured the plasma concentrations of taurine based on blood samples collected at nine-week gestation on average and obtained the data regarding both mothers and their infants from medical records. There was a significant increment in the mean value of HOMA-β across the tertiles of plasma taurine in multiparous women rather than in primiparous women. After adjustment for confounders, an increase of plasma taurine was nominally and significantly associated with a decrease risk of GDM; moreover, women with plasma taurine concentrations in the lowest tertile and in the second tertile had a higher risk of GDM than did those with plasma taurine in the top tertile in multiparous women other than primiparous women. Plasma taurine level seems to be associated with insulin secretion in early pregnancy and be more closely associated with β-cell function and the risk of GDM development in multiparas in comparison to primiparas.Peng Ju LiuYanping LiuLiangkun MaLihong LiuTing HuZhuoling AnAi Min YaoLiang Yu XiaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peng Ju Liu Yanping Liu Liangkun Ma Lihong Liu Ting Hu Zhuoling An Ai Min Yao Liang Yu Xia The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women
description	Abstract Taurine is a sulfur-containing amino acid that plays an important role in glucose homeostasis. However, it remains unknown whether the plasma concentration of taurine affects the risk of later gestational diabetes mellitus (GDM) development. We recruited 398 singleton-pregnancy women and followed up them during the course of pregnancy. We measured the plasma concentrations of taurine based on blood samples collected at nine-week gestation on average and obtained the data regarding both mothers and their infants from medical records. There was a significant increment in the mean value of HOMA-β across the tertiles of plasma taurine in multiparous women rather than in primiparous women. After adjustment for confounders, an increase of plasma taurine was nominally and significantly associated with a decrease risk of GDM; moreover, women with plasma taurine concentrations in the lowest tertile and in the second tertile had a higher risk of GDM than did those with plasma taurine in the top tertile in multiparous women other than primiparous women. Plasma taurine level seems to be associated with insulin secretion in early pregnancy and be more closely associated with β-cell function and the risk of GDM development in multiparas in comparison to primiparas.
format	article
author	Peng Ju Liu Yanping Liu Liangkun Ma Lihong Liu Ting Hu Zhuoling An Ai Min Yao Liang Yu Xia
author_facet	Peng Ju Liu Yanping Liu Liangkun Ma Lihong Liu Ting Hu Zhuoling An Ai Min Yao Liang Yu Xia
author_sort	Peng Ju Liu
title	The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women
title_short	The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women
title_full	The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women
title_fullStr	The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women
title_full_unstemmed	The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women
title_sort	relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in chinese pregnant women
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a0ea151b9174466be110d343c500eb6
work_keys_str_mv	AT pengjuliu therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT yanpingliu therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT liangkunma therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT lihongliu therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT tinghu therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT zhuolingan therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT aiminyao therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT liangyuxia therelationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT pengjuliu relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT yanpingliu relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT liangkunma relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT lihongliu relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT tinghu relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT zhuolingan relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT aiminyao relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen AT liangyuxia relationshipbetweenplasmataurinelevelsinearlypregnancyandlatergestationaldiabetesmellitusriskinchinesepregnantwomen
_version_	1718385646419050496

The relationship between plasma taurine levels in early pregnancy and later gestational diabetes mellitus risk in Chinese pregnant women

Ejemplares similares