TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway

The unfolded protein response allows tumour cells to adapt to ER stress, and aberrant activation of Nrf2 confers cancer progression. Here, the authors show that TRIM25 is induced during ER stress and promotes tumour cell survival by targeting Keap1 for degradation, leading to Nrf2 activation.

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Autores principales:	Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li, Zhihuan Li, Lilong Lin, Xiaochun Wan, Xiaolu Yang, Liang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8a113faa8cad44bca1e2d4948f32e7c0
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spelling	oai:doaj.org-article:8a113faa8cad44bca1e2d4948f32e7c02021-12-02T16:49:30ZTRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway10.1038/s41467-019-14190-22041-1723https://doaj.org/article/8a113faa8cad44bca1e2d4948f32e7c02020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14190-2https://doaj.org/toc/2041-1723The unfolded protein response allows tumour cells to adapt to ER stress, and aberrant activation of Nrf2 confers cancer progression. Here, the authors show that TRIM25 is induced during ER stress and promotes tumour cell survival by targeting Keap1 for degradation, leading to Nrf2 activation.Yanfeng LiuShishi TaoLijuan LiaoYang LiHongchang LiZhihuan LiLilong LinXiaochun WanXiaolu YangLiang ChenNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yanfeng Liu Shishi Tao Lijuan Liao Yang Li Hongchang Li Zhihuan Li Lilong Lin Xiaochun Wan Xiaolu Yang Liang Chen TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
description	The unfolded protein response allows tumour cells to adapt to ER stress, and aberrant activation of Nrf2 confers cancer progression. Here, the authors show that TRIM25 is induced during ER stress and promotes tumour cell survival by targeting Keap1 for degradation, leading to Nrf2 activation.
format	article
author	Yanfeng Liu Shishi Tao Lijuan Liao Yang Li Hongchang Li Zhihuan Li Lilong Lin Xiaochun Wan Xiaolu Yang Liang Chen
author_facet	Yanfeng Liu Shishi Tao Lijuan Liao Yang Li Hongchang Li Zhihuan Li Lilong Lin Xiaochun Wan Xiaolu Yang Liang Chen
author_sort	Yanfeng Liu
title	TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
title_short	TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
title_full	TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
title_fullStr	TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
title_full_unstemmed	TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
title_sort	trim25 promotes the cell survival and growth of hepatocellular carcinoma through targeting keap1-nrf2 pathway
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a113faa8cad44bca1e2d4948f32e7c0
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TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway

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