Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

Abstract Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To eluc...

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Autores principales:	Kumiko Taira, Tomonori Kawakami, Sujithra Kaushaliya Weragoda, H. M. Ayala S. Herath, Yoshinori Ikenaka, Kazutoshi Fujioka, Madhubhani Hemachandra, Nirmalie Pallewatta, Yoshiko Aoyama, Mayumi Ishizuka, Jean-Marc Bonmatin, Makiko Komori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a127f36d91a4f04b2ebb6dddb074c98
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spelling	oai:doaj.org-article:8a127f36d91a4f04b2ebb6dddb074c982021-11-21T12:17:16ZUrinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka10.1038/s41598-021-01732-22045-2322https://doaj.org/article/8a127f36d91a4f04b2ebb6dddb074c982021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01732-2https://doaj.org/toc/2045-2322Abstract Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the relationship between renal tubular dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, and 62 neighbors in 2015, analyzed two renal tubular biomarkers, Cystatin-C and L-FABP, quantified seven neonicotinoids and a metabolite N-desmethyl-acetamiprid by LC–MS/MS; and we investigated their symptoms using a questionnaire. Cystatin-C and L-FABP had a positive correlation (p < 0.001). N-Desmethyl-acetamiprid was detected in 92.4% of the urine samples, followed by dinotefuran (17.4%), thiamethoxam (17.4%), clothianidin (9.8%), thiacloprid and imidacloprid. Dinotefuran and thiacloprid have never been registered in Sri Lanka. In High Cystatin-C group (> 70 μg/gCre, n = 7), higher urinary concentration of dinotefuran (p = 0.009), and in Zero Cystatin-C group (< LOQ, n = 7), higher N-desmethyl-acetamiprid (p = 0.013), dinotefuran (p = 0.049), and thiacloprid (p = 0.035), and more complaints of chest pains, stomachache, skin eruption and diarrhea (p < 0.05) were found than in Normal Cystatin-C group (n = 78). Urinary neonicotinoids may be one of the potential risk factors for renal tubular dysfunction in this area.Kumiko TairaTomonori KawakamiSujithra Kaushaliya WeragodaH. M. Ayala S. HerathYoshinori IkenakaKazutoshi FujiokaMadhubhani HemachandraNirmalie PallewattaYoshiko AoyamaMayumi IshizukaJean-Marc BonmatinMakiko KomoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kumiko Taira Tomonori Kawakami Sujithra Kaushaliya Weragoda H. M. Ayala S. Herath Yoshinori Ikenaka Kazutoshi Fujioka Madhubhani Hemachandra Nirmalie Pallewatta Yoshiko Aoyama Mayumi Ishizuka Jean-Marc Bonmatin Makiko Komori Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
description	Abstract Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in the North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) of unknown etiology has been increasing since the 1990’s. To elucidate the relationship between renal tubular dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, and 62 neighbors in 2015, analyzed two renal tubular biomarkers, Cystatin-C and L-FABP, quantified seven neonicotinoids and a metabolite N-desmethyl-acetamiprid by LC–MS/MS; and we investigated their symptoms using a questionnaire. Cystatin-C and L-FABP had a positive correlation (p < 0.001). N-Desmethyl-acetamiprid was detected in 92.4% of the urine samples, followed by dinotefuran (17.4%), thiamethoxam (17.4%), clothianidin (9.8%), thiacloprid and imidacloprid. Dinotefuran and thiacloprid have never been registered in Sri Lanka. In High Cystatin-C group (> 70 μg/gCre, n = 7), higher urinary concentration of dinotefuran (p = 0.009), and in Zero Cystatin-C group (< LOQ, n = 7), higher N-desmethyl-acetamiprid (p = 0.013), dinotefuran (p = 0.049), and thiacloprid (p = 0.035), and more complaints of chest pains, stomachache, skin eruption and diarrhea (p < 0.05) were found than in Normal Cystatin-C group (n = 78). Urinary neonicotinoids may be one of the potential risk factors for renal tubular dysfunction in this area.
format	article
author	Kumiko Taira Tomonori Kawakami Sujithra Kaushaliya Weragoda H. M. Ayala S. Herath Yoshinori Ikenaka Kazutoshi Fujioka Madhubhani Hemachandra Nirmalie Pallewatta Yoshiko Aoyama Mayumi Ishizuka Jean-Marc Bonmatin Makiko Komori
author_facet	Kumiko Taira Tomonori Kawakami Sujithra Kaushaliya Weragoda H. M. Ayala S. Herath Yoshinori Ikenaka Kazutoshi Fujioka Madhubhani Hemachandra Nirmalie Pallewatta Yoshiko Aoyama Mayumi Ishizuka Jean-Marc Bonmatin Makiko Komori
author_sort	Kumiko Taira
title	Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_short	Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_full	Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_fullStr	Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_full_unstemmed	Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka
title_sort	urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in dry-zone of sri lanka
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a127f36d91a4f04b2ebb6dddb074c98
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Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

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