COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL

Objective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents. Study Design: Comparative cross sectional study. Place and Duration of...

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Autores principales:	Muhammad Tanveer Sajid, Sami Ur Rehman, Muhammad Akmal, Hussain Ahmad, Zahoor Iqbal Mirza, Arshad Mahmood
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	luts solifenacin ureteric stent-related symptoms tamsulosin ipss Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8a1365e6cec04bcdbff60316cc2472e0
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spelling	oai:doaj.org-article:8a1365e6cec04bcdbff60316cc2472e02021-12-02T18:44:46ZCOMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL0030-96482411-884210.51253/pafmj.v71i1.2617https://doaj.org/article/8a1365e6cec04bcdbff60316cc2472e02021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2617https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents. Study Design: Comparative cross sectional study. Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi from Sep 2018 to Feb 2019. Methodology: A total of two hundred (n=200) patients of either gender aged 20-50 years, who underwent unilateral DJ stenting for different endourological procedures, were enrolled after satisfying inclusion/exclusion criteria and then randomly allocated to group A (Solifenacin 5mg once daily (OD) ± placebo for 2 weeks) or group B (Solifenacin 5mg OD ± Tamsulosin 0.4 mg OD for 2 weeks) respectively. Baseline (1st post-operative day) and Post 02 weeks treatment IPSS was recorded and analyzed. Results: Mean age of presentation in group A and group B was 41.11 ± 6.45 vs 39.86 ± 5.34 years with p-value 0.14. Majority of patients in both groups were male (34% female in group A while 31% in group B, difference being statistically insignificant p 0.65). Baseline IPSS in group A and group B was 10.33 ± 2.72 vs 10.46 ± 3.12 with pvalue 0.76 (statistically insignificant) while post 02 weeks treatment IPSS in group A and B was 9.20 ± 2.67 vs 7.88 ± 2.63 respectively with p-value <0.001, the difference being statistically significant. Conclusions: Current study revealed significant advantage of combination therapy (solifenacin ± tamsulosin) compared with solifenacin monotherapy in lowering LUTS based on IPSS in patients having unilateral......Muhammad Tanveer SajidSami Ur RehmanMuhammad AkmalHussain AhmadZahoor Iqbal MirzaArshad MahmoodArmy Medical College Rawalpindiarticlelutssolifenacinureteric stent-related symptomstamsulosinipssMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 45-50 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	luts solifenacin ureteric stent-related symptoms tamsulosin ipss Medicine R Medicine (General) R5-920
spellingShingle	luts solifenacin ureteric stent-related symptoms tamsulosin ipss Medicine R Medicine (General) R5-920 Muhammad Tanveer Sajid Sami Ur Rehman Muhammad Akmal Hussain Ahmad Zahoor Iqbal Mirza Arshad Mahmood COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
description	Objective: To compare Solifenacin versus solifenacin plus tamsulosin in terms of international prostate symptom score (IPSS) for lower urinary tract symptoms (LUTS) in patients with unilateral double-J (DJ) ureteric stents. Study Design: Comparative cross sectional study. Place and Duration of Study: Armed Forces Institute of Urology, Rawalpindi from Sep 2018 to Feb 2019. Methodology: A total of two hundred (n=200) patients of either gender aged 20-50 years, who underwent unilateral DJ stenting for different endourological procedures, were enrolled after satisfying inclusion/exclusion criteria and then randomly allocated to group A (Solifenacin 5mg once daily (OD) ± placebo for 2 weeks) or group B (Solifenacin 5mg OD ± Tamsulosin 0.4 mg OD for 2 weeks) respectively. Baseline (1st post-operative day) and Post 02 weeks treatment IPSS was recorded and analyzed. Results: Mean age of presentation in group A and group B was 41.11 ± 6.45 vs 39.86 ± 5.34 years with p-value 0.14. Majority of patients in both groups were male (34% female in group A while 31% in group B, difference being statistically insignificant p 0.65). Baseline IPSS in group A and group B was 10.33 ± 2.72 vs 10.46 ± 3.12 with pvalue 0.76 (statistically insignificant) while post 02 weeks treatment IPSS in group A and B was 9.20 ± 2.67 vs 7.88 ± 2.63 respectively with p-value <0.001, the difference being statistically significant. Conclusions: Current study revealed significant advantage of combination therapy (solifenacin ± tamsulosin) compared with solifenacin monotherapy in lowering LUTS based on IPSS in patients having unilateral......
format	article
author	Muhammad Tanveer Sajid Sami Ur Rehman Muhammad Akmal Hussain Ahmad Zahoor Iqbal Mirza Arshad Mahmood
author_facet	Muhammad Tanveer Sajid Sami Ur Rehman Muhammad Akmal Hussain Ahmad Zahoor Iqbal Mirza Arshad Mahmood
author_sort	Muhammad Tanveer Sajid
title	COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
title_short	COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
title_full	COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
title_fullStr	COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
title_full_unstemmed	COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL
title_sort	comparison of solifenacin versus combination of solifenacin and tamsulosin in improving unilateral double-j stent related lower urinary tract symptoms - a prospective randomized control trial
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/8a1365e6cec04bcdbff60316cc2472e0
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COMPARISON OF SOLIFENACIN VERSUS COMBINATION OF SOLIFENACIN AND TAMSULOSIN IN IMPROVING UNILATERAL DOUBLE-J STENT RELATED LOWER URINARY TRACT SYMPTOMS - A PROSPECTIVE RANDOMIZED CONTROL TRIAL

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