Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy

Abstract Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting...

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Autores principales:	Rong Lin, Hongfang Ju, Ziyu Yuan, Liangliang Zeng, Yuantian Sun, Zhenyu Su, Yajun Yang, Yi Wang, Li Jin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a1445dbbe8143e49180a57178c9f1f6
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spelling	oai:doaj.org-article:8a1445dbbe8143e49180a57178c9f1f62021-12-02T15:05:07ZAssociation of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy10.1038/s41598-017-03518-x2045-2322https://doaj.org/article/8a1445dbbe8143e49180a57178c9f1f62017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03518-xhttps://doaj.org/toc/2045-2322Abstract Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-β) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Follow-up of 36 LEPR loci identified 3 maternal loci (rs10889567, rs1137101 and rs3762274) associated with fasting glucose, these 3 fetal loci associated with fasting insulin and HOMA1-IR, as well as these 3 maternal-fetal loci combinations associated with HOMA2-β. We also demonstrated association of maternal locus rs7554485 with HOMA2-β and HOMA2-IR, maternal locus rs10749754 with fasting glucose, fetal locus rs10749754 with HOMA2-IR. However, these associations were no longer statistically significant after Bonferroni correction. In conclusion, our results first revealed multiple associations between maternal and fetal LEPR common variants and gestational glycemic traits. These associations did not survive Bonferroni correction. These corrections are overly conservative for association studies. We therefore believe the influence of these nominally significant variants on gestational glycometabolism will be confirmed by additional studies.Rong LinHongfang JuZiyu YuanLiangliang ZengYuantian SunZhenyu SuYajun YangYi WangLi JinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rong Lin Hongfang Ju Ziyu Yuan Liangliang Zeng Yuantian Sun Zhenyu Su Yajun Yang Yi Wang Li Jin Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
description	Abstract Recent studies suggested that maternal and placental leptin receptor (LEPR) may be involved in maternal glucose metabolism in pregnancy. To identify maternal and fetal LEPR common variants influencing gestational glycemic traits, we performed association study of 24-28-week maternal fasting glucose, glucose 1 hour after the consumption of a 50-g oral glucose load, fasting insulin and indices of beta-cell function (HOMA-β) and insulin resistance (HOMA-IR) in 1,112 unrelated women and their children. Follow-up of 36 LEPR loci identified 3 maternal loci (rs10889567, rs1137101 and rs3762274) associated with fasting glucose, these 3 fetal loci associated with fasting insulin and HOMA1-IR, as well as these 3 maternal-fetal loci combinations associated with HOMA2-β. We also demonstrated association of maternal locus rs7554485 with HOMA2-β and HOMA2-IR, maternal locus rs10749754 with fasting glucose, fetal locus rs10749754 with HOMA2-IR. However, these associations were no longer statistically significant after Bonferroni correction. In conclusion, our results first revealed multiple associations between maternal and fetal LEPR common variants and gestational glycemic traits. These associations did not survive Bonferroni correction. These corrections are overly conservative for association studies. We therefore believe the influence of these nominally significant variants on gestational glycometabolism will be confirmed by additional studies.
format	article
author	Rong Lin Hongfang Ju Ziyu Yuan Liangliang Zeng Yuantian Sun Zhenyu Su Yajun Yang Yi Wang Li Jin
author_facet	Rong Lin Hongfang Ju Ziyu Yuan Liangliang Zeng Yuantian Sun Zhenyu Su Yajun Yang Yi Wang Li Jin
author_sort	Rong Lin
title	Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
title_short	Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
title_full	Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
title_fullStr	Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
title_full_unstemmed	Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy
title_sort	association of maternal and fetal lepr common variants with maternal glycemic traits during pregnancy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a1445dbbe8143e49180a57178c9f1f6
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_version_	1718388967990099968

Association of maternal and fetal LEPR common variants with maternal glycemic traits during pregnancy

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