Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study
Background: We aimed to longitudinally monitor the recovery in breathlessness, symptom burden, health-related quality-of-life, and mental health status in individuals hospitalised due to SARS-CoV-2 associated respiratory failure.Methods: Individuals hospitalised due to SARS-CoV-2 associated respirat...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Frontiers Media S.A.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8a153fa428b74f21a6df7c726d5f713e |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8a153fa428b74f21a6df7c726d5f713e |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8a153fa428b74f21a6df7c726d5f713e2021-11-30T17:22:17ZLongitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study2673-686110.3389/fresc.2021.777396https://doaj.org/article/8a153fa428b74f21a6df7c726d5f713e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fresc.2021.777396/fullhttps://doaj.org/toc/2673-6861Background: We aimed to longitudinally monitor the recovery in breathlessness, symptom burden, health-related quality-of-life, and mental health status in individuals hospitalised due to SARS-CoV-2 associated respiratory failure.Methods: Individuals hospitalised due to SARS-CoV-2 associated respiratory failure were recruited at hospital discharge in three participating centres. During the 90 day follow-up, European Quality of Life−5 Dimensions−5 Levels Instrument (EQ-5D-5L), modified Medical Research Council (mMRC) Dyspnoea Scale, COPD Assessment Test (CAT), and weekly Hospital Anxiety and Depression Scale (HADS) questionnaires were assessed using a smartphone application. The results were presented using descriptive statistics and graphics. Linear mixed models with random intercept were fitted to analyse differences of intensive-care unit status on the recovery course in each outcome.Results: We included 58 participants, 40 completed the study. From hospital discharge until 90 days post-discharge, EQ-5D-5L index changed from 0.83 (0.66, 0.92) to 0.96 (0.82, 1.0), VAS rating on general health status changed from 62 (50, 75) % to 80 (74, 94) %, CAT changed from 13 (10, 21) to 7 (3, 11) points, mMRC changed from 1 (0, 2) to 0 (0, 1) points, HADS depression subscale changed from 6 (4, 9) to 5 (1, 6) points, HADS anxiety subscale changed from 7 (3, 9) to 2 (1, 8) points. Differences in the recovery courses were observed between intensive-care and ward participants. Participants that were admitted to an intensive-care unit during their hospitalisation (n = 16) showed increases in CAT, mMRC, HADS scores, and decreases in EQ-5D-5L 30 days after hospital discharge.Conclusion: Being admitted to an ICU led to statistically significant reductions in recovery in the EQ-5D-5L and the CAT. Furthermore, the flare-up in symptom burden and depression scores, accompanied by an attenuated recovery in HrQoL and general health status in the ICU-group suggests that a clinical follow-up 1 month after hospital discharge can be recommended, evaluating further treatments.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [NCT04365595].Dario KohlbrennerDario KohlbrennerManuel KuhnManuel KuhnMelina Stüssi-HelblingYves NordmannMarc SpielmannsMarc SpielmannsChristian F. ClarenbachFrontiers Media S.A.articleSARS-CoV-2COVID-19respiratory failurequality-of-lifemental healthhome-monitoringOther systems of medicineRZ201-999Medical technologyR855-855.5ENFrontiers in Rehabilitation Sciences, Vol 2 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
SARS-CoV-2 COVID-19 respiratory failure quality-of-life mental health home-monitoring Other systems of medicine RZ201-999 Medical technology R855-855.5 |
| spellingShingle |
SARS-CoV-2 COVID-19 respiratory failure quality-of-life mental health home-monitoring Other systems of medicine RZ201-999 Medical technology R855-855.5 Dario Kohlbrenner Dario Kohlbrenner Manuel Kuhn Manuel Kuhn Melina Stüssi-Helbling Yves Nordmann Marc Spielmanns Marc Spielmanns Christian F. Clarenbach Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study |
| description |
Background: We aimed to longitudinally monitor the recovery in breathlessness, symptom burden, health-related quality-of-life, and mental health status in individuals hospitalised due to SARS-CoV-2 associated respiratory failure.Methods: Individuals hospitalised due to SARS-CoV-2 associated respiratory failure were recruited at hospital discharge in three participating centres. During the 90 day follow-up, European Quality of Life−5 Dimensions−5 Levels Instrument (EQ-5D-5L), modified Medical Research Council (mMRC) Dyspnoea Scale, COPD Assessment Test (CAT), and weekly Hospital Anxiety and Depression Scale (HADS) questionnaires were assessed using a smartphone application. The results were presented using descriptive statistics and graphics. Linear mixed models with random intercept were fitted to analyse differences of intensive-care unit status on the recovery course in each outcome.Results: We included 58 participants, 40 completed the study. From hospital discharge until 90 days post-discharge, EQ-5D-5L index changed from 0.83 (0.66, 0.92) to 0.96 (0.82, 1.0), VAS rating on general health status changed from 62 (50, 75) % to 80 (74, 94) %, CAT changed from 13 (10, 21) to 7 (3, 11) points, mMRC changed from 1 (0, 2) to 0 (0, 1) points, HADS depression subscale changed from 6 (4, 9) to 5 (1, 6) points, HADS anxiety subscale changed from 7 (3, 9) to 2 (1, 8) points. Differences in the recovery courses were observed between intensive-care and ward participants. Participants that were admitted to an intensive-care unit during their hospitalisation (n = 16) showed increases in CAT, mMRC, HADS scores, and decreases in EQ-5D-5L 30 days after hospital discharge.Conclusion: Being admitted to an ICU led to statistically significant reductions in recovery in the EQ-5D-5L and the CAT. Furthermore, the flare-up in symptom burden and depression scores, accompanied by an attenuated recovery in HrQoL and general health status in the ICU-group suggests that a clinical follow-up 1 month after hospital discharge can be recommended, evaluating further treatments.Clinical Trial Registration: [www.ClinicalTrials.gov], identifier [NCT04365595]. |
| format |
article |
| author |
Dario Kohlbrenner Dario Kohlbrenner Manuel Kuhn Manuel Kuhn Melina Stüssi-Helbling Yves Nordmann Marc Spielmanns Marc Spielmanns Christian F. Clarenbach |
| author_facet |
Dario Kohlbrenner Dario Kohlbrenner Manuel Kuhn Manuel Kuhn Melina Stüssi-Helbling Yves Nordmann Marc Spielmanns Marc Spielmanns Christian F. Clarenbach |
| author_sort |
Dario Kohlbrenner |
| title |
Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study |
| title_short |
Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study |
| title_full |
Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study |
| title_fullStr |
Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study |
| title_full_unstemmed |
Longitudinal Smartphone-Based Post-hospitalisation Symptom Monitoring in SARS-CoV-2 Associated Respiratory Failure: A Multi-Centre Observational Study |
| title_sort |
longitudinal smartphone-based post-hospitalisation symptom monitoring in sars-cov-2 associated respiratory failure: a multi-centre observational study |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/8a153fa428b74f21a6df7c726d5f713e |
| work_keys_str_mv |
AT dariokohlbrenner longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT dariokohlbrenner longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT manuelkuhn longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT manuelkuhn longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT melinastussihelbling longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT yvesnordmann longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT marcspielmanns longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT marcspielmanns longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy AT christianfclarenbach longitudinalsmartphonebasedposthospitalisationsymptommonitoringinsarscov2associatedrespiratoryfailureamulticentreobservationalstudy |
| _version_ |
1718406391942610944 |