Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas

Abstract We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compa...

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Autores principales:	Lavinia Carmen Uscătescu, Sarah Said-Yürekli, Lisa Kronbichler, Renate Stelzig-Schöler, Brandy-Gale Pearce, Luise Antonia Reich, Stefanie Weber, Wolfgang Aichhorn, Martin Kronbichler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/8a1bcfab3dd643e3ad8faaf17f562192
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spelling	oai:doaj.org-article:8a1bcfab3dd643e3ad8faaf17f5621922021-11-28T12:13:59ZReduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas10.1038/s41537-021-00184-x2334-265Xhttps://doaj.org/article/8a1bcfab3dd643e3ad8faaf17f5621922021-11-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00184-xhttps://doaj.org/toc/2334-265XAbstract We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.Lavinia Carmen UscătescuSarah Said-YürekliLisa KronbichlerRenate Stelzig-SchölerBrandy-Gale PearceLuise Antonia ReichStefanie WeberWolfgang AichhornMartin KronbichlerNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Lavinia Carmen Uscătescu Sarah Said-Yürekli Lisa Kronbichler Renate Stelzig-Schöler Brandy-Gale Pearce Luise Antonia Reich Stefanie Weber Wolfgang Aichhorn Martin Kronbichler Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
description	Abstract We computed intrinsic neural timescales (INT) based on resting-state functional magnetic resonance imaging (rsfMRI) data of healthy controls (HC) and patients with schizophrenia spectrum disorder (SZ) from three independently collected samples. Five clusters showed decreased INT in SZ compared to HC in all three samples: right occipital fusiform gyrus (rOFG), left superior occipital gyrus (lSOG), right superior occipital gyrus (rSOG), left lateral occipital cortex (lLOC) and right postcentral gyrus (rPG). In other words, it appears that sensory information in visual and posterior parietal areas is stored for reduced lengths of time in SZ compared to HC. Finally, we found that symptom severity appears to modulate INT of these areas in SZ.
format	article
author	Lavinia Carmen Uscătescu Sarah Said-Yürekli Lisa Kronbichler Renate Stelzig-Schöler Brandy-Gale Pearce Luise Antonia Reich Stefanie Weber Wolfgang Aichhorn Martin Kronbichler
author_facet	Lavinia Carmen Uscătescu Sarah Said-Yürekli Lisa Kronbichler Renate Stelzig-Schöler Brandy-Gale Pearce Luise Antonia Reich Stefanie Weber Wolfgang Aichhorn Martin Kronbichler
author_sort	Lavinia Carmen Uscătescu
title	Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
title_short	Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
title_full	Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
title_fullStr	Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
title_full_unstemmed	Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
title_sort	reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8a1bcfab3dd643e3ad8faaf17f562192
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Reduced intrinsic neural timescales in schizophrenia along posterior parietal and occipital areas

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