ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS

Background: Normal-Tension_Glaucoma (NTG) is an eye disease and characterize with low intraocular pressure (IOP) levels. In population-based settings, the diagnose of glaucoma is based on the IOP levels of 21 mmHg, and its usually delayed. A recent study HbA1c levels could lead to IOP changes. Obstr...

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Auteurs principaux:	Seskoati Prayitnaningsih, Virna Dwi Oktariana Asrory, Synthia Nusanti, Erlin Listyaningsih, Bambang Budi Siswanto, Anwar Santoso
Format:	article
Langue:	EN ID
Publié:	University of Brawijaya 2021
Sujets:	hba1c normal-tension glaucoma neutrophil-lymphocyte ratio metabolic syndrome Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Accès en ligne:	https://doaj.org/article/8a1e1b3f90644dae9ab9053d49cec1ad
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spelling	oai:doaj.org-article:8a1e1b3f90644dae9ab9053d49cec1ad2021-11-24T07:33:33ZASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS10.21776/ub.mnj.2021.007.02.142407-67242442-5001https://doaj.org/article/8a1e1b3f90644dae9ab9053d49cec1ad2021-07-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/544https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Background: Normal-Tension_Glaucoma (NTG) is an eye disease and characterize with low intraocular pressure (IOP) levels. In population-based settings, the diagnose of glaucoma is based on the IOP levels of 21 mmHg, and its usually delayed. A recent study HbA1c levels could lead to IOP changes. Obstructive Sleep Apnea (OSA) result oxidative stress that results an altered function of neutrophil in patients with NTG. Objective: To_evaluate the association of HbA1c, Netrophil-to-Lymphocyte Ratio_(NLR) toward NTG as its novel early detection. Methods: This study divided into two groups consisted of Metabolic Syndrome ( MS) + OSA without eye disorder as control (15 subjects) and MS + OSA + NTG patients (14 subjects). IDF criteria was used to established MS, and risk of OSA determined by STOP-BANG Questionnaire. The diagnosis of NTG was confirmed by normal IOP measured by Tonopen. Mean Defect (MD) of visual field evaluated by Automated Humphrey Perimetry, Retinal Nerve Fiber Layer (RNFL) established by OCT. HbA1c measured by ELISA and NLR by flowcytometry. Statistical analysis consisted of comparison and correlation test Results: The ratio of CD was significantly higher in NTG patients (0.54 ± 0.13) compared to control (0.26 ± 0.07; p<0.001). MD was also higher in subjects with NTG (6.80 ± 3.90) compared to control (4.97 ± 2.28; p=0.134). Mean RNFL was lower in subjects with NTG (87.95 ± 28.29) compared to control (95.07 ± 26.66; p=0.035). Positive correlation between HbA1C-MD (r = 0.456, p = 0.013) and NLR-RNFL thinning (r = 0.525, p = 0.003) was existed in Metabolic Syndrome (MS) patients. Conclusion: Patients with MS and OSA risk have an increased risk of NTG. A novel association between Hba1C levels, NLR and NTG was also identiﬁed. Seskoati PrayitnaningsihVirna Dwi Oktariana AsrorySynthia NusantiErlin ListyaningsihBambang Budi SiswantoAnwar SantosoUniversity of Brawijayaarticlehba1cnormal-tension glaucomaneutrophil-lymphocyte ratiometabolic syndromeMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 2, Pp 149-155 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	hba1c normal-tension glaucoma neutrophil-lymphocyte ratio metabolic syndrome Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	hba1c normal-tension glaucoma neutrophil-lymphocyte ratio metabolic syndrome Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Seskoati Prayitnaningsih Virna Dwi Oktariana Asrory Synthia Nusanti Erlin Listyaningsih Bambang Budi Siswanto Anwar Santoso ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
description	Background: Normal-Tension_Glaucoma (NTG) is an eye disease and characterize with low intraocular pressure (IOP) levels. In population-based settings, the diagnose of glaucoma is based on the IOP levels of 21 mmHg, and its usually delayed. A recent study HbA1c levels could lead to IOP changes. Obstructive Sleep Apnea (OSA) result oxidative stress that results an altered function of neutrophil in patients with NTG. Objective: To_evaluate the association of HbA1c, Netrophil-to-Lymphocyte Ratio_(NLR) toward NTG as its novel early detection. Methods: This study divided into two groups consisted of Metabolic Syndrome ( MS) + OSA without eye disorder as control (15 subjects) and MS + OSA + NTG patients (14 subjects). IDF criteria was used to established MS, and risk of OSA determined by STOP-BANG Questionnaire. The diagnosis of NTG was confirmed by normal IOP measured by Tonopen. Mean Defect (MD) of visual field evaluated by Automated Humphrey Perimetry, Retinal Nerve Fiber Layer (RNFL) established by OCT. HbA1c measured by ELISA and NLR by flowcytometry. Statistical analysis consisted of comparison and correlation test Results: The ratio of CD was significantly higher in NTG patients (0.54 ± 0.13) compared to control (0.26 ± 0.07; p<0.001). MD was also higher in subjects with NTG (6.80 ± 3.90) compared to control (4.97 ± 2.28; p=0.134). Mean RNFL was lower in subjects with NTG (87.95 ± 28.29) compared to control (95.07 ± 26.66; p=0.035). Positive correlation between HbA1C-MD (r = 0.456, p = 0.013) and NLR-RNFL thinning (r = 0.525, p = 0.003) was existed in Metabolic Syndrome (MS) patients. Conclusion: Patients with MS and OSA risk have an increased risk of NTG. A novel association between Hba1C levels, NLR and NTG was also identiﬁed.
format	article
author	Seskoati Prayitnaningsih Virna Dwi Oktariana Asrory Synthia Nusanti Erlin Listyaningsih Bambang Budi Siswanto Anwar Santoso
author_facet	Seskoati Prayitnaningsih Virna Dwi Oktariana Asrory Synthia Nusanti Erlin Listyaningsih Bambang Budi Siswanto Anwar Santoso
author_sort	Seskoati Prayitnaningsih
title	ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
title_short	ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
title_full	ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
title_fullStr	ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
title_full_unstemmed	ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS
title_sort	association of hba1c and neutrophil lymphocyte ratio with normal-tension glaucoma in metabolic syndrome and obstructive sleep apnea risk patients
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/8a1e1b3f90644dae9ab9053d49cec1ad
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ASSOCIATION OF HBA1C AND NEUTROPHIL LYMPHOCYTE RATIO WITH NORMAL-TENSION GLAUCOMA IN METABOLIC SYNDROME AND OBSTRUCTIVE SLEEP APNEA RISK PATIENTS

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