The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR‐27a‐5p and control of UBE2N levels

The lncRNA ‘UCA1’ modulates the response to chemotherapy of ovarian cancer through direct binding to miR‐27a‐5p and control of UBE2N levels

Ovarian cancer (OC) is the leading cause of death in patients with gynecologic cancers. Due to late diagnosis and resistance to chemotherapy, the 5‐year survival rate in patients with OC is below 40%. We observed that UCA1, a lncRNA previously reported to play an oncogenic role in several malignanci...

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Bibliographic Details
Main Authors: Anaïs Wambecke, Mohammad Ahmad, Pierre‐Marie Morice, Bernard Lambert, Louis‐Bastien Weiswald, Mégane Vernon, Nicolas Vigneron, Edwige Abeilard, Emilie Brotin, Martin Figeac, Pascal Gauduchon, Laurent Poulain, Christophe Denoyelle, Matthieu Meryet‐Figuiere
Format: article
Language:EN
Published: Wiley 2021
Subjects:
ceRNA
chemoresistance
miR‐27a‐5p
ovarian cancer
patient‐derived organoid
lncRNA UCA1
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/8a1e4e42fbc5491cb25a6a66c4690349
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https://doaj.org/article/8a1e4e42fbc5491cb25a6a66c4690349

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