Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes

Recent studies have shown that individuals with sickle cell disease (SCD) exhibit greater vasoconstriction responses to physical autonomic stressors, such as heat pain and cold pain than normal individuals, but this is not the case for mental stress (MTS). We sought to determine whether this anomalo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wanwara Thuptimdang, Payal Shah, Maha Khaleel, John Sunwoo, Saranya Veluswamy, Roberta M. Kato, Thomas D. Coates, Michael C. K. Khoo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	sickle cell anemia mental stress vasoconstriction baroreflex autonomic nervous system Physiology QP1-981
Acceso en línea:	https://doaj.org/article/8a1f6d398282464c97055a0c2d43c456
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a1f6d398282464c97055a0c2d43c456
record_format	dspace
spelling	oai:doaj.org-article:8a1f6d398282464c97055a0c2d43c4562021-11-04T05:32:03ZVasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes1664-042X10.3389/fphys.2021.698209https://doaj.org/article/8a1f6d398282464c97055a0c2d43c4562021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.698209/fullhttps://doaj.org/toc/1664-042XRecent studies have shown that individuals with sickle cell disease (SCD) exhibit greater vasoconstriction responses to physical autonomic stressors, such as heat pain and cold pain than normal individuals, but this is not the case for mental stress (MTS). We sought to determine whether this anomalous finding for MTS is related to inter-group differences in baseline cardiac and vascular autonomic function. Fifteen subjects with SCD and 15 healthy volunteers participated in three MTS tasks: N-back, Stroop, and pain anticipation (PA). R–R interval (RRI), arterial blood pressure and finger photoplethysmogram (PPG) were continuously monitored before and during these MTS tasks. The magnitude of vasoconstriction was quantified using change in PPG amplitude (PPGa) from the baseline period. To represent basal autonomic function, we assessed both cardiac and vascular arms of the baroreflex during the baseline period. Cardiac baroreflex sensitivity (BRSc) was estimated by applying both the “sequence” and “spectral” techniques to beat-to-beat measurements of systolic blood pressure and RRIs. The vascular baroreflex sensitivity (BRSv) was quantified using the same approaches, modified for application to beat-to-beat diastolic blood pressure and PPGa measurements. Baseline BRSc was not different between SCD and non-SCD subjects, was not correlated with BRSv, and was not associated with the vasoconstriction responses to MTS tasks. BRSv in both groups was correlated with mean PPGa, and since both baseline PPGa and BRSv were lower in SCD, these results suggested that the SCD subjects were in a basal state of higher sympathetically mediated vascular tone. In both groups, baseline BRSv was positively correlated with the vasoconstriction responses to N-back, Stroop, and PA. After adjusting for differences in BRSv within and between groups, we found no difference in the vasoconstriction responses to all three mental tasks between SCD and non-SCD subjects. The implications of these findings are significant in subjects with SCD since vasoconstriction reduces microvascular flow and prolongs capillary transit time, increasing the likelihood for vaso-occlusive crisis (VOC) to be triggered by exposure to stressful events.Wanwara ThuptimdangPayal ShahMaha KhaleelJohn SunwooSaranya VeluswamyRoberta M. KatoThomas D. CoatesMichael C. K. KhooFrontiers Media S.A.articlesickle cell anemiamental stressvasoconstrictionbaroreflexautonomic nervous systemPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	sickle cell anemia mental stress vasoconstriction baroreflex autonomic nervous system Physiology QP1-981
spellingShingle	sickle cell anemia mental stress vasoconstriction baroreflex autonomic nervous system Physiology QP1-981 Wanwara Thuptimdang Payal Shah Maha Khaleel John Sunwoo Saranya Veluswamy Roberta M. Kato Thomas D. Coates Michael C. K. Khoo Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
description	Recent studies have shown that individuals with sickle cell disease (SCD) exhibit greater vasoconstriction responses to physical autonomic stressors, such as heat pain and cold pain than normal individuals, but this is not the case for mental stress (MTS). We sought to determine whether this anomalous finding for MTS is related to inter-group differences in baseline cardiac and vascular autonomic function. Fifteen subjects with SCD and 15 healthy volunteers participated in three MTS tasks: N-back, Stroop, and pain anticipation (PA). R–R interval (RRI), arterial blood pressure and finger photoplethysmogram (PPG) were continuously monitored before and during these MTS tasks. The magnitude of vasoconstriction was quantified using change in PPG amplitude (PPGa) from the baseline period. To represent basal autonomic function, we assessed both cardiac and vascular arms of the baroreflex during the baseline period. Cardiac baroreflex sensitivity (BRSc) was estimated by applying both the “sequence” and “spectral” techniques to beat-to-beat measurements of systolic blood pressure and RRIs. The vascular baroreflex sensitivity (BRSv) was quantified using the same approaches, modified for application to beat-to-beat diastolic blood pressure and PPGa measurements. Baseline BRSc was not different between SCD and non-SCD subjects, was not correlated with BRSv, and was not associated with the vasoconstriction responses to MTS tasks. BRSv in both groups was correlated with mean PPGa, and since both baseline PPGa and BRSv were lower in SCD, these results suggested that the SCD subjects were in a basal state of higher sympathetically mediated vascular tone. In both groups, baseline BRSv was positively correlated with the vasoconstriction responses to N-back, Stroop, and PA. After adjusting for differences in BRSv within and between groups, we found no difference in the vasoconstriction responses to all three mental tasks between SCD and non-SCD subjects. The implications of these findings are significant in subjects with SCD since vasoconstriction reduces microvascular flow and prolongs capillary transit time, increasing the likelihood for vaso-occlusive crisis (VOC) to be triggered by exposure to stressful events.
format	article
author	Wanwara Thuptimdang Payal Shah Maha Khaleel John Sunwoo Saranya Veluswamy Roberta M. Kato Thomas D. Coates Michael C. K. Khoo
author_facet	Wanwara Thuptimdang Payal Shah Maha Khaleel John Sunwoo Saranya Veluswamy Roberta M. Kato Thomas D. Coates Michael C. K. Khoo
author_sort	Wanwara Thuptimdang
title	Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
title_short	Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
title_full	Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
title_fullStr	Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
title_full_unstemmed	Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes
title_sort	vasoconstriction response to mental stress in sickle cell disease: the role of the cardiac and vascular baroreflexes
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8a1f6d398282464c97055a0c2d43c456
work_keys_str_mv	AT wanwarathuptimdang vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT payalshah vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT mahakhaleel vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT johnsunwoo vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT saranyaveluswamy vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT robertamkato vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT thomasdcoates vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes AT michaelckkhoo vasoconstrictionresponsetomentalstressinsicklecelldiseasetheroleofthecardiacandvascularbaroreflexes
_version_	1718445223452868608

Vasoconstriction Response to Mental Stress in Sickle Cell Disease: The Role of the Cardiac and Vascular Baroreflexes

Ejemplares similares