Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment

Abstract Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the ke...

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Autores principales:	L. Golubewa, I. Timoshchenko, O. Romanov, R. Karpicz, T. Kulahava, D. Rutkauskas, M. Shuba, A. Dementjev, Yu. Svirko, P. Kuzhir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a2045075c5f45f9b55b0f47aaa73ed1
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spelling	oai:doaj.org-article:8a2045075c5f45f9b55b0f47aaa73ed12021-12-02T12:42:27ZSingle-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment10.1038/s41598-020-79238-62045-2322https://doaj.org/article/8a2045075c5f45f9b55b0f47aaa73ed12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79238-6https://doaj.org/toc/2045-2322Abstract Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. Here, we demonstrate that agglomerated single-walled carbon nanotubes (SWCNTs) are promising theranostic agent that enables photo-activated ‘cold’ destruction of the cancer cells keeping their environment alive. The absorption of picosecond pulses by SWCNT agglomerates results in the mechanical (due to photoacoustic effect) rather than photothermal cancer cell destruction, which was visualized by micro-Raman and ultrafast near-infrared CARS. The developed theoretical model allows us to distinguish photothermal, photoacoustic, and photothermoacoustic regimes of the cancer cell destruction, and also to optimize SWCNT-based theranostics recipe.L. GolubewaI. TimoshchenkoO. RomanovR. KarpiczT. KulahavaD. RutkauskasM. ShubaA. DementjevYu. SvirkoP. KuzhirNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. Golubewa I. Timoshchenko O. Romanov R. Karpicz T. Kulahava D. Rutkauskas M. Shuba A. Dementjev Yu. Svirko P. Kuzhir Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
description	Abstract Theranostics is the emerging field of medicine that uniquely combines diagnostic techniques and active agents to diagnose and treat medical conditions simultaneously or sequentially. Finding a theranostic agent capable to cure the affected cells and being safe for the healthy ones is the key for successful treatment. Here, we demonstrate that agglomerated single-walled carbon nanotubes (SWCNTs) are promising theranostic agent that enables photo-activated ‘cold’ destruction of the cancer cells keeping their environment alive. The absorption of picosecond pulses by SWCNT agglomerates results in the mechanical (due to photoacoustic effect) rather than photothermal cancer cell destruction, which was visualized by micro-Raman and ultrafast near-infrared CARS. The developed theoretical model allows us to distinguish photothermal, photoacoustic, and photothermoacoustic regimes of the cancer cell destruction, and also to optimize SWCNT-based theranostics recipe.
format	article
author	L. Golubewa I. Timoshchenko O. Romanov R. Karpicz T. Kulahava D. Rutkauskas M. Shuba A. Dementjev Yu. Svirko P. Kuzhir
author_facet	L. Golubewa I. Timoshchenko O. Romanov R. Karpicz T. Kulahava D. Rutkauskas M. Shuba A. Dementjev Yu. Svirko P. Kuzhir
author_sort	L. Golubewa
title	Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
title_short	Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
title_full	Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
title_fullStr	Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
title_full_unstemmed	Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
title_sort	single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8a2045075c5f45f9b55b0f47aaa73ed1
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Single-walled carbon nanotubes as a photo-thermo-acoustic cancer theranostic agent: theory and proof of the concept experiment

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