Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study

Intermittent theta-burst stimulation (iTBS) is a high-efficiency transcranial magnetic stimulation (TMS) paradigm that has been applied to post-stroke aphasia (PSA). However, its efficacy mechanisms have not been clarified. This study aimed to explore the immediate effects of iTBS of the primary mot...

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Autores principales:	Shuo Xu, Qing Yang, Mengye Chen, Panmo Deng, Ren Zhuang, Zengchun Sun, Chong Li, Zhijie Yan, Yongli Zhang, Jie Jia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stroke aphasia iTBS fMRI neuroplasticity rehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/8a2132e0816740c1a9882283011cd71a
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spelling	oai:doaj.org-article:8a2132e0816740c1a9882283011cd71a2021-11-25T16:57:40ZCapturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study10.3390/brainsci111114512076-3425https://doaj.org/article/8a2132e0816740c1a9882283011cd71a2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1451https://doaj.org/toc/2076-3425Intermittent theta-burst stimulation (iTBS) is a high-efficiency transcranial magnetic stimulation (TMS) paradigm that has been applied to post-stroke aphasia (PSA). However, its efficacy mechanisms have not been clarified. This study aimed to explore the immediate effects of iTBS of the primary motor cortex (M1) of the affected hemisphere, on the functional activities and connectivity of the brains of PSA patients. A total of 16 patients with aphasia after stroke received iTBS with 800 pulses for 300 s. All patients underwent motor, language, and cognitive assessments and resting-state functional MRI scans immediately before and after the iTBS intervention. Regional, seed-based connectivity, and graph-based measures were used to test the immediate functional effects of the iTBS intervention, including the fractional amplitude of low-frequency fluctuation (fALFF), degree centrality (DC), and functional connectivity (FC) of the left M1 area throughout the whole brain. The results showed that after one session of iTBS intervention, the fALFF, DC, and FC values changed significantly in the patients’ brains. Specifically, the DC values were significantly higher in the right middle frontal gyrus and parts of the left parietal lobe (<i>p</i> < 0.05), while fALFF values were significantly lower in the right medial frontal lobe and parts of the left intracalcarine cortex (<i>p</i> < 0.05), and the strength of the functional connectivity between the left M1 area and the left superior frontal gyrus was reduced (<i>p</i> < 0.05). Our findings provided preliminary evidences that the iTBS on the ipsilesional M1 could induce neural activity and functional connectivity changes in the motor, language, and other brain regions in patients with PSA, which may promote neuroplasticity and functional recovery.Shuo XuQing YangMengye ChenPanmo DengRen ZhuangZengchun SunChong LiZhijie YanYongli ZhangJie JiaMDPI AGarticlestrokeaphasiaiTBSfMRIneuroplasticityrehabilitationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1451, p 1451 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke aphasia iTBS fMRI neuroplasticity rehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	stroke aphasia iTBS fMRI neuroplasticity rehabilitation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Shuo Xu Qing Yang Mengye Chen Panmo Deng Ren Zhuang Zengchun Sun Chong Li Zhijie Yan Yongli Zhang Jie Jia Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
description	Intermittent theta-burst stimulation (iTBS) is a high-efficiency transcranial magnetic stimulation (TMS) paradigm that has been applied to post-stroke aphasia (PSA). However, its efficacy mechanisms have not been clarified. This study aimed to explore the immediate effects of iTBS of the primary motor cortex (M1) of the affected hemisphere, on the functional activities and connectivity of the brains of PSA patients. A total of 16 patients with aphasia after stroke received iTBS with 800 pulses for 300 s. All patients underwent motor, language, and cognitive assessments and resting-state functional MRI scans immediately before and after the iTBS intervention. Regional, seed-based connectivity, and graph-based measures were used to test the immediate functional effects of the iTBS intervention, including the fractional amplitude of low-frequency fluctuation (fALFF), degree centrality (DC), and functional connectivity (FC) of the left M1 area throughout the whole brain. The results showed that after one session of iTBS intervention, the fALFF, DC, and FC values changed significantly in the patients’ brains. Specifically, the DC values were significantly higher in the right middle frontal gyrus and parts of the left parietal lobe (<i>p</i> < 0.05), while fALFF values were significantly lower in the right medial frontal lobe and parts of the left intracalcarine cortex (<i>p</i> < 0.05), and the strength of the functional connectivity between the left M1 area and the left superior frontal gyrus was reduced (<i>p</i> < 0.05). Our findings provided preliminary evidences that the iTBS on the ipsilesional M1 could induce neural activity and functional connectivity changes in the motor, language, and other brain regions in patients with PSA, which may promote neuroplasticity and functional recovery.
format	article
author	Shuo Xu Qing Yang Mengye Chen Panmo Deng Ren Zhuang Zengchun Sun Chong Li Zhijie Yan Yongli Zhang Jie Jia
author_facet	Shuo Xu Qing Yang Mengye Chen Panmo Deng Ren Zhuang Zengchun Sun Chong Li Zhijie Yan Yongli Zhang Jie Jia
author_sort	Shuo Xu
title	Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
title_short	Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
title_full	Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
title_fullStr	Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
title_full_unstemmed	Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study
title_sort	capturing neuroplastic changes after itbs in patients with post-stroke aphasia: a pilot fmri study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8a2132e0816740c1a9882283011cd71a
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Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A Pilot fMRI Study

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