Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life
BackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study i...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:8a2587e5bdae470fa9404c984598004d2021-11-19T07:26:45ZCitrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life1664-322410.3389/fimmu.2021.774433https://doaj.org/article/8a2587e5bdae470fa9404c984598004d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.774433/fullhttps://doaj.org/toc/1664-3224BackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder via regulation of gut microbiome in mice exposed to antibodies early in life were investigated.Methods and ResultsThree-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. The results showed that early-life AZT exposure promoted HFD-induced glycolipid metabolism disorder, increased the levels of inflammatory factors, promoted the flora metabolism product trimethylamine N-oxide (TMAO), and induced microbial disorder in adult mice. Importantly, CRP extract mitigated these effects.ConclusionTaken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome.Hanqi LuYanting YouXinghong ZhouQiuxing HeMing WangLiqian ChenLin ZhouXiaomin SunYanyan LiuPingping JiangJiaojiao DaiXiuqiong FuHiu Yee KwanXiaoshan ZhaoXiaoshan ZhaoLinjie LouFrontiers Media S.A.articleCitrus reticulata pericarpium extractearly lifeantibiotic exposureglycolipid metabolism disorderTMAOImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021) |
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DOAJ |
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EN |
| topic |
Citrus reticulata pericarpium extract early life antibiotic exposure glycolipid metabolism disorder TMAO Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
Citrus reticulata pericarpium extract early life antibiotic exposure glycolipid metabolism disorder TMAO Immunologic diseases. Allergy RC581-607 Hanqi Lu Yanting You Xinghong Zhou Qiuxing He Ming Wang Liqian Chen Lin Zhou Xiaomin Sun Yanyan Liu Pingping Jiang Jiaojiao Dai Xiuqiong Fu Hiu Yee Kwan Xiaoshan Zhao Xiaoshan Zhao Linjie Lou Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| description |
BackgroundStudies have shown that gut microbe disorder in mice due to early-life antibiotic exposure promotes glycolipid metabolism disorder in adulthood. However, the underlying mechanism remains unclear and there is not yet an effective intervention or treatment for this process.PurposeThe study investigated whether early-life azithromycin (AZT) exposure in mice could promote high-fat diet (HFD)-induced glycolipid metabolism disorder in adulthood. Moreover, the effect of citrus reticulata pericarpium (CRP) extract on glycolipid metabolism disorder via regulation of gut microbiome in mice exposed to antibodies early in life were investigated.Methods and ResultsThree-week-old mice were treated with AZT (50 mg/kg/day) via drinking water for two weeks and then were fed a CRP diet (1% CRP extract) for four weeks and an HFD for five weeks. The results showed that early-life AZT exposure promoted HFD-induced glycolipid metabolism disorder, increased the levels of inflammatory factors, promoted the flora metabolism product trimethylamine N-oxide (TMAO), and induced microbial disorder in adult mice. Importantly, CRP extract mitigated these effects.ConclusionTaken together, these findings suggest that early-life AZT exposure increases the susceptibility to HFD-induced glycolipid metabolism disorder in adult mice, and CRP extract can decrease this susceptibility by regulating gut microbiome. |
| format |
article |
| author |
Hanqi Lu Yanting You Xinghong Zhou Qiuxing He Ming Wang Liqian Chen Lin Zhou Xiaomin Sun Yanyan Liu Pingping Jiang Jiaojiao Dai Xiuqiong Fu Hiu Yee Kwan Xiaoshan Zhao Xiaoshan Zhao Linjie Lou |
| author_facet |
Hanqi Lu Yanting You Xinghong Zhou Qiuxing He Ming Wang Liqian Chen Lin Zhou Xiaomin Sun Yanyan Liu Pingping Jiang Jiaojiao Dai Xiuqiong Fu Hiu Yee Kwan Xiaoshan Zhao Xiaoshan Zhao Linjie Lou |
| author_sort |
Hanqi Lu |
| title |
Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_short |
Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_full |
Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_fullStr |
Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_full_unstemmed |
Citrus reticulatae pericarpium Extract Decreases the Susceptibility to HFD-Induced Glycolipid Metabolism Disorder in Mice Exposed to Azithromycin in Early Life |
| title_sort |
citrus reticulatae pericarpium extract decreases the susceptibility to hfd-induced glycolipid metabolism disorder in mice exposed to azithromycin in early life |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/8a2587e5bdae470fa9404c984598004d |
| work_keys_str_mv |
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