The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability

Centella asiatica extract has low solubility in water. Material modification needs to be conducted to increase the dissolution rate of Centella asiatica extract. The particle size reduction to nano-size was carried out to increase surface contact with aqueous media. High surface contact was expected...

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Autores principales:	Aditya Trias Pradana, Roisah Nawatila, Fawandi Fuad Alkindi, Ni Putu Resa Darmayani, Eka Desi Susanti
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Ahmad Dahlan 2021
Materias:	nanoparticle centella asiatica quercetin β-cyclodextrin maltodextrin spray-drying Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8a259bab49974e71b6f07ad4b2962bac
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spelling	oai:doaj.org-article:8a259bab49974e71b6f07ad4b2962bac2021-11-18T00:41:00ZThe effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability10.12928/pharmaciana.v11i3.215342088-45592477-0256https://doaj.org/article/8a259bab49974e71b6f07ad4b2962bac2021-11-01T00:00:00Zhttp://journal.uad.ac.id/index.php/PHARMACIANA/article/view/21534/pdf_215https://doaj.org/toc/2088-4559https://doaj.org/toc/2477-0256Centella asiatica extract has low solubility in water. Material modification needs to be conducted to increase the dissolution rate of Centella asiatica extract. The particle size reduction to nano-size was carried out to increase surface contact with aqueous media. High surface contact was expected to increase the solubility and absorption rate. Nanoparticles were prepared with 34% maltodextrin and 6% β-cyclodextrin as a stabilizer and dried by a spray-drying method. High temperature in the spray drying process can affect the physical and chemical characteristics of the nanoparticles, so the inlet temperature in this study was observed as parameter variations, on 140oC, 150oC, and 160oC. The formed nanoparticles then being tested on several parameters, including physical appearance, moisture content, particle size, shape, and morphology. The chemical stability of the active ingredients during the drying process was assessed from the pH value changes and the content of quercetin as an antioxidant post drying process, compared to the initial content. The test results show that the nanoparticles have been formed. The inlet temperature of 160oC produced the most physically optimum spherical nanoparticles, with a particle size of 191.533 ± 18.791 nm and relatively homogeneous with a polydispersity index (PDI) value of 0.113 ± 0.057. However, temperatures that are too high indicate poor chemical stability. The poor chemical stability can be seen from the quercetin content that decreased significantly after the drying process, until the remaining 53.87 ± 0.55% and 49.52 ± 0.97% for temperatures of 140oC and 160oC, respectively. These results indicate that the combination of β-cyclodextrin and maltodextrin can not encapsulate and maintain the stability of the active ingredients during the spray drying process. A significant reduction of inlet temperature is needed to get dry nanoparticles with the most optimum physical mixture and chemical stability.Aditya Trias Pradana Roisah NawatilaFawandi Fuad Alkindi Ni Putu Resa DarmayaniEka Desi SusantiUniversitas Ahmad Dahlanarticlenanoparticlecentella asiaticaquercetinβ-cyclodextrinmaltodextrinspray-dryingPharmacy and materia medicaRS1-441ENPharmaciana, Vol 11, Iss 3, Pp 394-405 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanoparticle centella asiatica quercetin β-cyclodextrin maltodextrin spray-drying Pharmacy and materia medica RS1-441
spellingShingle	nanoparticle centella asiatica quercetin β-cyclodextrin maltodextrin spray-drying Pharmacy and materia medica RS1-441 Aditya Trias Pradana Roisah Nawatila Fawandi Fuad Alkindi Ni Putu Resa Darmayani Eka Desi Susanti The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
description	Centella asiatica extract has low solubility in water. Material modification needs to be conducted to increase the dissolution rate of Centella asiatica extract. The particle size reduction to nano-size was carried out to increase surface contact with aqueous media. High surface contact was expected to increase the solubility and absorption rate. Nanoparticles were prepared with 34% maltodextrin and 6% β-cyclodextrin as a stabilizer and dried by a spray-drying method. High temperature in the spray drying process can affect the physical and chemical characteristics of the nanoparticles, so the inlet temperature in this study was observed as parameter variations, on 140oC, 150oC, and 160oC. The formed nanoparticles then being tested on several parameters, including physical appearance, moisture content, particle size, shape, and morphology. The chemical stability of the active ingredients during the drying process was assessed from the pH value changes and the content of quercetin as an antioxidant post drying process, compared to the initial content. The test results show that the nanoparticles have been formed. The inlet temperature of 160oC produced the most physically optimum spherical nanoparticles, with a particle size of 191.533 ± 18.791 nm and relatively homogeneous with a polydispersity index (PDI) value of 0.113 ± 0.057. However, temperatures that are too high indicate poor chemical stability. The poor chemical stability can be seen from the quercetin content that decreased significantly after the drying process, until the remaining 53.87 ± 0.55% and 49.52 ± 0.97% for temperatures of 140oC and 160oC, respectively. These results indicate that the combination of β-cyclodextrin and maltodextrin can not encapsulate and maintain the stability of the active ingredients during the spray drying process. A significant reduction of inlet temperature is needed to get dry nanoparticles with the most optimum physical mixture and chemical stability.
format	article
author	Aditya Trias Pradana Roisah Nawatila Fawandi Fuad Alkindi Ni Putu Resa Darmayani Eka Desi Susanti
author_facet	Aditya Trias Pradana Roisah Nawatila Fawandi Fuad Alkindi Ni Putu Resa Darmayani Eka Desi Susanti
author_sort	Aditya Trias Pradana
title	The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
title_short	The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
title_full	The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
title_fullStr	The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
title_full_unstemmed	The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
title_sort	effect of spray-drying temperature on centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability
publisher	Universitas Ahmad Dahlan
publishDate	2021
url	https://doaj.org/article/8a259bab49974e71b6f07ad4b2962bac
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The effect of spray-drying temperature on Centella asiatica extract-β cyclodextrin-maltodextrin nanoparticle characteristics and stability

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