Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Alexandra Iulia Irimie,1 Laura Sonea,2 Ancuta Jurj,3 Nikolay Mehterov,4,5 Alina Andreea Zimta,2,3 Liviuta Budisan,3 Cornelia Braicu,3 Ioana Berindan-Neagoe2,3,6 1Department of Prosthodontics and Dental Materials, Faculty of Dental Medicine, 2MedFuture Research Center for Advanced Medicine, 3Researc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Irimie AI, Sonea L, Jurj A, Mehterov N, Zimta AA, Budisan L, Braicu C, Berindan-Neagoe I
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	oral cancer nanoparticle lipidic nanosystems polymeric micelles and dendrimers Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8a291741deb34b4a8e5e82dd6fcc8201
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a291741deb34b4a8e5e82dd6fcc8201
record_format	dspace
spelling	oai:doaj.org-article:8a291741deb34b4a8e5e82dd6fcc82012021-12-02T02:42:20ZFuture trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer1178-2013https://doaj.org/article/8a291741deb34b4a8e5e82dd6fcc82012017-06-01T00:00:00Zhttps://www.dovepress.com/future-trends-and-emerging-issues-for-nanodelivery-systems-in-oral-and-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Alexandra Iulia Irimie,1 Laura Sonea,2 Ancuta Jurj,3 Nikolay Mehterov,4,5 Alina Andreea Zimta,2,3 Liviuta Budisan,3 Cornelia Braicu,3 Ioana Berindan-Neagoe2,3,6 1Department of Prosthodontics and Dental Materials, Faculty of Dental Medicine, 2MedFuture Research Center for Advanced Medicine, 3Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4Department of Medical Biology, Medical University of Plovdiv, 5Technological Center for Emergency Medicine, Plovdiv, Bulgaria; 6Department of Functional Genomics and Experimental Pathology, Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania Abstract: Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed. Keywords: oral cancer, nanoparticle, lipidic nanosystems, polymeric micelles, dendrimersIrimie AISonea LJurj AMehterov NZimta AABudisan LBraicu CBerindan-Neagoe IDove Medical Pressarticleoral cancernanoparticlelipidic nanosystemspolymeric micelles and dendrimersMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 4593-4606 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	oral cancer nanoparticle lipidic nanosystems polymeric micelles and dendrimers Medicine (General) R5-920
spellingShingle	oral cancer nanoparticle lipidic nanosystems polymeric micelles and dendrimers Medicine (General) R5-920 Irimie AI Sonea L Jurj A Mehterov N Zimta AA Budisan L Braicu C Berindan-Neagoe I Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
description	Alexandra Iulia Irimie,1 Laura Sonea,2 Ancuta Jurj,3 Nikolay Mehterov,4,5 Alina Andreea Zimta,2,3 Liviuta Budisan,3 Cornelia Braicu,3 Ioana Berindan-Neagoe2,3,6 1Department of Prosthodontics and Dental Materials, Faculty of Dental Medicine, 2MedFuture Research Center for Advanced Medicine, 3Research Center for Functional Genomics and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 4Department of Medical Biology, Medical University of Plovdiv, 5Technological Center for Emergency Medicine, Plovdiv, Bulgaria; 6Department of Functional Genomics and Experimental Pathology, Ion Chiricuta Oncology Institute, Cluj-Napoca, Romania Abstract: Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed. Keywords: oral cancer, nanoparticle, lipidic nanosystems, polymeric micelles, dendrimers
format	article
author	Irimie AI Sonea L Jurj A Mehterov N Zimta AA Budisan L Braicu C Berindan-Neagoe I
author_facet	Irimie AI Sonea L Jurj A Mehterov N Zimta AA Budisan L Braicu C Berindan-Neagoe I
author_sort	Irimie AI
title	Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
title_short	Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
title_full	Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
title_fullStr	Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
title_full_unstemmed	Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
title_sort	future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/8a291741deb34b4a8e5e82dd6fcc8201
work_keys_str_mv	AT irimieai futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT soneal futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT jurja futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT mehterovn futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT zimtaaa futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT budisanl futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT braicuc futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer AT berindanneagoei futuretrendsandemergingissuesfornanodeliverysystemsinoralandoropharyngealcancer
_version_	1718402232447139840

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Ejemplares similares