Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery

Gauri M Nabar,1 Kalpesh D Mahajan,1 Mark A Calhoun,2 Anthony D Duong,1 Matthew S Souva,1 Jihong Xu,3,4 Catherine Czeisler,5 Vinay K Puduvalli,3,4 José Javier Otero,5 Barbara E Wyslouzil,1,6 Jessica O Winter1,2 1William G Lowrie Department of Chemical and Biomolecular Engineering, 2Depart...

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Autores principales:	Nabar GM, Mahajan KD, Calhoun MA, Duong AD, Souva MS, Xu J, Czeisler C, Puduvalli VK, Otero JJ, Wyslouzil BE, Winter JO
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	PLGA nanoparticles micelles drug delivery hydrophobic drug Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8a2a798c9805434d8bdb18c5c7075bf1
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spelling	oai:doaj.org-article:8a2a798c9805434d8bdb18c5c7075bf12021-12-02T01:58:50ZMicelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery1178-2013https://doaj.org/article/8a2a798c9805434d8bdb18c5c7075bf12018-01-01T00:00:00Zhttps://www.dovepress.com/micelle-templated-polylactic-co-glycolic-acid-nanoparticles-for-hydrop-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Gauri M Nabar,1 Kalpesh D Mahajan,1 Mark A Calhoun,2 Anthony D Duong,1 Matthew S Souva,1 Jihong Xu,3,4 Catherine Czeisler,5 Vinay K Puduvalli,3,4 José Javier Otero,5 Barbara E Wyslouzil,1,6 Jessica O Winter1,2 1William G Lowrie Department of Chemical and Biomolecular Engineering, 2Department of Biomedical Engineering, 3Division of Neuro-oncology, College of Medicine, The Ohio State University Comprehensive Cancer Center, 4Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurosurgery, College of Medicine, The Ohio State University Comprehensive Cancer Center, 5Department of Pathology and the Neurological Research Institute, College of Medicine, 6Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA Purpose: Poly(lactic-co-glycolic acid) (PLGA) is widely used for drug delivery because of its biocompatibility, ability to solubilize a wide variety of drugs, and tunable degradation. However, achieving sub-100 nm nanoparticles (NPs), as might be desired for delivery via the enhanced permeability and retention effect, is extremely difficult via typical top-down emulsion approaches.Methods: Here, we present a bottom-up synthesis method yielding PLGA/block copolymer hybrids (ie, “PolyDots”), consisting of hydrophobic PLGA chains entrapped within self-assembling poly(styrene-b-ethylene oxide) (PS-b-PEO) micelles.Results: PolyDots exhibit average diameters <50 nm and lower polydispersity than conventional PLGA NPs. Drug encapsulation efficiencies of PolyDots match conventional PLGA NPs (ie, ~30%) and are greater than those obtained from PS-b-PEO micelles (ie, ~7%). Increasing the PLGA:PS-b-PEO weight ratio alters the drug release mechanism from chain relaxation to erosion controlled. PolyDots are taken up by model glioma cells via endocytotic mechanisms within 24 hours, providing a potential means for delivery to cytoplasm. PolyDots can be lyophilized with minimal change in morphology and encapsulant functionality, and can be produced at scale using electrospray.Conclusion: Encapsulation of PLGA within micelles provides a bottom-up route for the synthesis of sub-100 nm PLGA-based nanocarriers with enhanced stability and drug-loading capacity, and tunable drug release, suitable for potential clinical applications. Keywords: PLGA, nanoparticles, micelles, drug delivery, hydrophobic drug, block copolymer, glioma, electrosprayNabar GMMahajan KDCalhoun MADuong ADSouva MSXu JCzeisler CPuduvalli VKOtero JJWyslouzil BEWinter JODove Medical PressarticlePLGAnanoparticlesmicellesdrug deliveryhydrophobic drugMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 351-366 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	PLGA nanoparticles micelles drug delivery hydrophobic drug Medicine (General) R5-920
spellingShingle	PLGA nanoparticles micelles drug delivery hydrophobic drug Medicine (General) R5-920 Nabar GM Mahajan KD Calhoun MA Duong AD Souva MS Xu J Czeisler C Puduvalli VK Otero JJ Wyslouzil BE Winter JO Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
description	Gauri M Nabar,1 Kalpesh D Mahajan,1 Mark A Calhoun,2 Anthony D Duong,1 Matthew S Souva,1 Jihong Xu,3,4 Catherine Czeisler,5 Vinay K Puduvalli,3,4 José Javier Otero,5 Barbara E Wyslouzil,1,6 Jessica O Winter1,2 1William G Lowrie Department of Chemical and Biomolecular Engineering, 2Department of Biomedical Engineering, 3Division of Neuro-oncology, College of Medicine, The Ohio State University Comprehensive Cancer Center, 4Dardinger Laboratory for Neuro-oncology and Neurosciences, Department of Neurosurgery, College of Medicine, The Ohio State University Comprehensive Cancer Center, 5Department of Pathology and the Neurological Research Institute, College of Medicine, 6Department of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, USA Purpose: Poly(lactic-co-glycolic acid) (PLGA) is widely used for drug delivery because of its biocompatibility, ability to solubilize a wide variety of drugs, and tunable degradation. However, achieving sub-100 nm nanoparticles (NPs), as might be desired for delivery via the enhanced permeability and retention effect, is extremely difficult via typical top-down emulsion approaches.Methods: Here, we present a bottom-up synthesis method yielding PLGA/block copolymer hybrids (ie, “PolyDots”), consisting of hydrophobic PLGA chains entrapped within self-assembling poly(styrene-b-ethylene oxide) (PS-b-PEO) micelles.Results: PolyDots exhibit average diameters <50 nm and lower polydispersity than conventional PLGA NPs. Drug encapsulation efficiencies of PolyDots match conventional PLGA NPs (ie, ~30%) and are greater than those obtained from PS-b-PEO micelles (ie, ~7%). Increasing the PLGA:PS-b-PEO weight ratio alters the drug release mechanism from chain relaxation to erosion controlled. PolyDots are taken up by model glioma cells via endocytotic mechanisms within 24 hours, providing a potential means for delivery to cytoplasm. PolyDots can be lyophilized with minimal change in morphology and encapsulant functionality, and can be produced at scale using electrospray.Conclusion: Encapsulation of PLGA within micelles provides a bottom-up route for the synthesis of sub-100 nm PLGA-based nanocarriers with enhanced stability and drug-loading capacity, and tunable drug release, suitable for potential clinical applications. Keywords: PLGA, nanoparticles, micelles, drug delivery, hydrophobic drug, block copolymer, glioma, electrospray
format	article
author	Nabar GM Mahajan KD Calhoun MA Duong AD Souva MS Xu J Czeisler C Puduvalli VK Otero JJ Wyslouzil BE Winter JO
author_facet	Nabar GM Mahajan KD Calhoun MA Duong AD Souva MS Xu J Czeisler C Puduvalli VK Otero JJ Wyslouzil BE Winter JO
author_sort	Nabar GM
title	Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
title_short	Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
title_full	Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
title_fullStr	Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
title_full_unstemmed	Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
title_sort	micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/8a2a798c9805434d8bdb18c5c7075bf1
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Micelle-templated, poly(lactic-co-glycolic acid) nanoparticles for hydrophobic drug delivery

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