Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series

Endoscopic treatment of large laterally spreading tumors (LSTs) with a focus of submucosally invasive colorectal cancer (T1 CRC) can be challenging. We evaluated outcomes of a hybrid resection technique using piecemeal endoscopic mucosal resection (pEMR) and endoscopic full-thickness resection (eFTR...

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Autores principales:	Jamie S. Chua, Hao Dang, Liselotte W. Zwager, Nik Dekkers, James C. H. Hardwick, Alexandra M. J. Langers, Jolein van der Kraan, Lars E. Perk, Barbara A. J. Bastiaansen, Jurjen J. Boonstra
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/8a2ac82e35a4401bae44d04f61f06121
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spelling	oai:doaj.org-article:8a2ac82e35a4401bae44d04f61f061212021-11-13T00:00:31ZHybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series2364-37222196-973610.1055/a-1529-1447https://doaj.org/article/8a2ac82e35a4401bae44d04f61f061212021-11-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/a-1529-1447https://doaj.org/toc/2364-3722https://doaj.org/toc/2196-9736Endoscopic treatment of large laterally spreading tumors (LSTs) with a focus of submucosally invasive colorectal cancer (T1 CRC) can be challenging. We evaluated outcomes of a hybrid resection technique using piecemeal endoscopic mucosal resection (pEMR) and endoscopic full-thickness resection (eFTR) in patients with large colonic LSTs containing suspected T1 CRC. Six hybrid pEMR-eFTR procedures for T1 CRCs were registered in a nationwide eFTR registry between July 2015 and December 2019. In all cases, the invasive part of the lesion was successfully isolated with eFTR; with eFTR, histologically complete resection of the invasive part was achieved in 5 /6 patients (83.3 %). No adverse events occurred during or after the procedure. The median follow-up time was 10 months (range 6–27), with all patients having undergone ≥ 1 surveillance colonoscopy. One patient had a small adenomatous recurrence, which was removed endoscopically. In conclusion, hybrid pEMR-eFTR is a promising noninvasive treatment modality that seems feasible for a selected group of patients with large LSTs containing a small focus of T1 CRC.Jamie S. ChuaHao DangLiselotte W. ZwagerNik DekkersJames C. H. HardwickAlexandra M. J. LangersJolein van der KraanLars E. PerkBarbara A. J. BastiaansenJurjen J. BoonstraGeorg Thieme Verlag KGarticleDiseases of the digestive system. GastroenterologyRC799-869ENEndoscopy International Open, Vol 09, Iss 11, Pp E1686-E1691 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 Jamie S. Chua Hao Dang Liselotte W. Zwager Nik Dekkers James C. H. Hardwick Alexandra M. J. Langers Jolein van der Kraan Lars E. Perk Barbara A. J. Bastiaansen Jurjen J. Boonstra Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
description	Endoscopic treatment of large laterally spreading tumors (LSTs) with a focus of submucosally invasive colorectal cancer (T1 CRC) can be challenging. We evaluated outcomes of a hybrid resection technique using piecemeal endoscopic mucosal resection (pEMR) and endoscopic full-thickness resection (eFTR) in patients with large colonic LSTs containing suspected T1 CRC. Six hybrid pEMR-eFTR procedures for T1 CRCs were registered in a nationwide eFTR registry between July 2015 and December 2019. In all cases, the invasive part of the lesion was successfully isolated with eFTR; with eFTR, histologically complete resection of the invasive part was achieved in 5 /6 patients (83.3 %). No adverse events occurred during or after the procedure. The median follow-up time was 10 months (range 6–27), with all patients having undergone ≥ 1 surveillance colonoscopy. One patient had a small adenomatous recurrence, which was removed endoscopically. In conclusion, hybrid pEMR-eFTR is a promising noninvasive treatment modality that seems feasible for a selected group of patients with large LSTs containing a small focus of T1 CRC.
format	article
author	Jamie S. Chua Hao Dang Liselotte W. Zwager Nik Dekkers James C. H. Hardwick Alexandra M. J. Langers Jolein van der Kraan Lars E. Perk Barbara A. J. Bastiaansen Jurjen J. Boonstra
author_facet	Jamie S. Chua Hao Dang Liselotte W. Zwager Nik Dekkers James C. H. Hardwick Alexandra M. J. Langers Jolein van der Kraan Lars E. Perk Barbara A. J. Bastiaansen Jurjen J. Boonstra
author_sort	Jamie S. Chua
title	Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
title_short	Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
title_full	Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
title_fullStr	Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
title_full_unstemmed	Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
title_sort	hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/8a2ac82e35a4401bae44d04f61f06121
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Hybrid endoscopic mucosal resection and full-thickness resection for large colonic polyps harboring a small focus of invasive cancer: a case series

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