A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers
Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of <i>Lactobacillus</i> <i>casei</i> LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbi...
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2021
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oai:doaj.org-article:8a2addd535e541a7976aef1bb371d5f22021-11-25T18:35:04ZA Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers10.3390/nu131138912072-6643https://doaj.org/article/8a2addd535e541a7976aef1bb371d5f22021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3891https://doaj.org/toc/2072-6643Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of <i>Lactobacillus</i> <i>casei</i> LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (<i>p</i> < 0.0001), while malondialdehyde (MDA) levels decreased (<i>p</i> < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (<i>p</i> < 0.05, respectively). <i>Escherichia coli</i>, <i>Enterococcus</i>, and <i>Bacteroides</i> expression was significantly reduced (<i>p</i> < 0.05), while <i>Clostridium leptum</i>, <i>Bifidobacterium</i>, and <i>Lactobacillus</i> expression increased (<i>p</i> < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group’s overall score was higher than that of the placebo group. The results of this pilot study suggest <i>L. casei</i> LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors.Li-Hua MeiWen-Xuan ZhengZheng-Tao ZhaoNing MengQin-Ren ZhangWen-Jun ZhuRui-Ding LiXiao-Lin LiangQuan-Yang LiMDPI AGarticleprobiotics<i>Lactobacillus casei</i> LTL1879healthy young peopleblood biochemicaloxidantinflammationNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3891, p 3891 (2021) |
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probiotics <i>Lactobacillus casei</i> LTL1879 healthy young people blood biochemical oxidant inflammation Nutrition. Foods and food supply TX341-641 |
| spellingShingle |
probiotics <i>Lactobacillus casei</i> LTL1879 healthy young people blood biochemical oxidant inflammation Nutrition. Foods and food supply TX341-641 Li-Hua Mei Wen-Xuan Zheng Zheng-Tao Zhao Ning Meng Qin-Ren Zhang Wen-Jun Zhu Rui-Ding Li Xiao-Lin Liang Quan-Yang Li A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
| description |
Probiotic intake has been shown to improve certain physiological health indicators. We aimed to examine effects of <i>Lactobacillus</i> <i>casei</i> LTL1879, obtained from long-lived elderly volunteers, on blood biochemical, oxidative, and inflammatory markers and gut microbiota in twenty healthy, young volunteers. Volunteers were randomly divided into equal probiotic and placebo groups and changes in blood biochemical indicators, oxidative and inflammatory markers, and gut microbiota were examined after three weeks of probiotic intervention. The probiotic group’s antioxidant levels were significantly enhanced post-intervention. Total antioxidant capacity (T-AOC) levels were significantly increased (<i>p</i> < 0.0001), while malondialdehyde (MDA) levels decreased (<i>p</i> < 0.05), and total superoxide dismutase (T-SOD) levels increased, but with no significant difference. In addition, Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) levels were significantly up-regulated and down-regulated (<i>p</i> < 0.05, respectively). <i>Escherichia coli</i>, <i>Enterococcus</i>, and <i>Bacteroides</i> expression was significantly reduced (<i>p</i> < 0.05), while <i>Clostridium leptum</i>, <i>Bifidobacterium</i>, and <i>Lactobacillus</i> expression increased (<i>p</i> < 0.05). Volunteer health status was quantified using principal components and cluster analysis, indicating that the probiotic group’s overall score was higher than that of the placebo group. The results of this pilot study suggest <i>L. casei</i> LTL 1879 can significantly improve specific immune, oxidative, and gut microbiota characteristics related to health factors. |
| format |
article |
| author |
Li-Hua Mei Wen-Xuan Zheng Zheng-Tao Zhao Ning Meng Qin-Ren Zhang Wen-Jun Zhu Rui-Ding Li Xiao-Lin Liang Quan-Yang Li |
| author_facet |
Li-Hua Mei Wen-Xuan Zheng Zheng-Tao Zhao Ning Meng Qin-Ren Zhang Wen-Jun Zhu Rui-Ding Li Xiao-Lin Liang Quan-Yang Li |
| author_sort |
Li-Hua Mei |
| title |
A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
| title_short |
A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
| title_full |
A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
| title_fullStr |
A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
| title_full_unstemmed |
A Pilot Study of the Effect of <i>Lactobacillus casei</i> Obtained from Long-Lived Elderly on Blood Biochemical, Oxidative, and Inflammatory Markers, and on Gut Microbiota in Young Volunteers |
| title_sort |
pilot study of the effect of <i>lactobacillus casei</i> obtained from long-lived elderly on blood biochemical, oxidative, and inflammatory markers, and on gut microbiota in young volunteers |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/8a2addd535e541a7976aef1bb371d5f2 |
| work_keys_str_mv |
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