Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish

Abstract Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density (BMD) in human. The aim of this study is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xing Wang, Shabnam Salimi, Zhongliang Deng, James Perry, Kathleen A. Ryan, Zhizhen Li, Dongfang Liu, Elizabeth Streeten, Alan R. Shuldiner, Mao Fu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a2e60e25ca74bc7afe8ed71568a7358
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8a2e60e25ca74bc7afe8ed71568a7358
record_format	dspace
spelling	oai:doaj.org-article:8a2e60e25ca74bc7afe8ed71568a73582021-12-02T11:41:04ZEvaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish10.1038/s41598-018-25272-42045-2322https://doaj.org/article/8a2e60e25ca74bc7afe8ed71568a73582018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25272-4https://doaj.org/toc/2045-2322Abstract Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density (BMD) in human. The aim of this study is to investigate the role of genetic variation in WISP1 gene as a determinant of BMD in 1,510 Old Order Amish (OOA). We performed regional association analysis of 58 tag variants within 5 kb upstream and downstream to WISP1 with BMD and found 5 variants that were associated with BMD at multiple skeletal sites (P values from 2.89 × 10−6 to 1.62 × 10−2), with some significant associations even after adjustment for multiple comparisons. To replicate these results in an independent dataset, we performed a look-up of BMD associations with these variants in European ancestry subjects from the large GEFOS Consortium and observed the nominal associations of two of these variants with BMD (P values: 0.031 to 0.048). In conclusion, we have demonstrated that genetic variants surrounding WISP1 are associated with BMD at multiple skeletal sites in the OOA, thus influencing osteoporosis risk. These results support a role for the WISP1 gene on influencing variation in BMD.Xing WangShabnam SalimiZhongliang DengJames PerryKathleen A. RyanZhizhen LiDongfang LiuElizabeth StreetenAlan R. ShuldinerMao FuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xing Wang Shabnam Salimi Zhongliang Deng James Perry Kathleen A. Ryan Zhizhen Li Dongfang Liu Elizabeth Streeten Alan R. Shuldiner Mao Fu Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
description	Abstract Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density (BMD) in human. The aim of this study is to investigate the role of genetic variation in WISP1 gene as a determinant of BMD in 1,510 Old Order Amish (OOA). We performed regional association analysis of 58 tag variants within 5 kb upstream and downstream to WISP1 with BMD and found 5 variants that were associated with BMD at multiple skeletal sites (P values from 2.89 × 10−6 to 1.62 × 10−2), with some significant associations even after adjustment for multiple comparisons. To replicate these results in an independent dataset, we performed a look-up of BMD associations with these variants in European ancestry subjects from the large GEFOS Consortium and observed the nominal associations of two of these variants with BMD (P values: 0.031 to 0.048). In conclusion, we have demonstrated that genetic variants surrounding WISP1 are associated with BMD at multiple skeletal sites in the OOA, thus influencing osteoporosis risk. These results support a role for the WISP1 gene on influencing variation in BMD.
format	article
author	Xing Wang Shabnam Salimi Zhongliang Deng James Perry Kathleen A. Ryan Zhizhen Li Dongfang Liu Elizabeth Streeten Alan R. Shuldiner Mao Fu
author_facet	Xing Wang Shabnam Salimi Zhongliang Deng James Perry Kathleen A. Ryan Zhizhen Li Dongfang Liu Elizabeth Streeten Alan R. Shuldiner Mao Fu
author_sort	Xing Wang
title	Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
title_short	Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
title_full	Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
title_fullStr	Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
title_full_unstemmed	Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish
title_sort	evaluation of wisp1 as a candidate gene for bone mineral density in the old order amish
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8a2e60e25ca74bc7afe8ed71568a7358
work_keys_str_mv	AT xingwang evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT shabnamsalimi evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT zhongliangdeng evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT jamesperry evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT kathleenaryan evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT zhizhenli evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT dongfangliu evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT elizabethstreeten evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT alanrshuldiner evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish AT maofu evaluationofwisp1asacandidategeneforbonemineraldensityintheoldorderamish
_version_	1718395471398961152

Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish

Ejemplares similares