Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes

Watcharaporn Thongmee,1 Chanomporn Narongkhananukul,1 Tanyatuth Padungkiatsagul,1 Panitha Jindahra,2 Kavin Vanikieti1 1Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahi...

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Autores principales:	Thongmee W, Narongkhananukul C, Padungkiatsagul T, Jindahra P, Vanikieti K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	late-onset optic neuritis neuromyelitis optica spectrum disorder thai Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8a32247d2cea46828c97b446b38dac43
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spelling	oai:doaj.org-article:8a32247d2cea46828c97b446b38dac432021-12-02T13:30:38ZComparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes1177-5483https://doaj.org/article/8a32247d2cea46828c97b446b38dac432021-02-01T00:00:00Zhttps://www.dovepress.com/comparison-of-early--and-late-onset-nmosd-related-optic-neuritis-in-th-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Watcharaporn Thongmee,1 Chanomporn Narongkhananukul,1 Tanyatuth Padungkiatsagul,1 Panitha Jindahra,2 Kavin Vanikieti1 1Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kavin Vanikieti Email Vanikieti.kavin@gmail.comObjective: To compare demographic data, clinical and radiological characteristics, treatments, and long-term visual outcomes between patients with late-onset neuromyelitis optica spectrum disorder-related optic neuritis (LO-NMOSD-ON) (age at onset ≥ 50 years) and patients with early-onset neuromyelitis optica spectrum disorder-related optic neuritis (EO-NMOSD-ON) (age at onset < 50 years).Patients and Methods: This retrospective study included 47 patients (69 eyes) who were diagnosed with neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) over a 12-year period. There were 14 patients (21 eyes) and 33 patients (48 eyes) in the LO-NMOSD-ON and EO-NMOSD-ON groups, respectively.Results: LO-NMOSD-ON–affected eyes exhibited significantly worse median nadir visual acuity (VA) at optic neuritis (ON) onset, compared with EO-NMOSD-ON–affected eyes (2.7 logMAR (range 2.6– 2.9 logMAR) vs 1.95 logMAR (range 0.4– 2.9 logMAR); p = 0.03). Similarly, 100% of LO-NMOSD-ON–affected eyes demonstrated a nadir VA of worse than or equal to 1.0 logMAR, compared with 62.5% of EO-NMOSD-ON–affected eyes (p = 0.03). LO-NMOSD-ON–affected eyes had a worse median final VA, compared with EO-NMOSD-ON–affected eyes (1.3 logMAR (range 0– 2.9 logMAR) vs 0.3 logMAR (range 0– 2.9 logMAR); adjusted p = 0.037). LO-NMOSD-ON–affected eyes more frequently exhibited a final VA of worse than or equal to 1.0 logMAR, compared with EO-NMOSD-ON–affected eyes (57.1% vs 27.0%; adjusted p = 0.039). A positive correlation was observed between age at ON onset of each eye and the final VA (logMAR) (Spearman r = 0.34, p = 0.0075). The remaining parameters did not significantly differ between the two groups.Conclusion: Patients with LO-NMOSD-ON had significantly worse nadir VA at ON onset and significantly worse final VA, relative to patients with EO-NMOSD-ON. Age at ON onset of each eye was positively correlated with final VA (logMAR). Despite the difference in common age at onset, NMOSD-ON should be included in the differential diagnosis of late-onset acute to subacute optic neuropathy, along with ischemic optic neuropathy.Keywords: late-onset, optic neuritis, neuromyelitis optica spectrum disorder, ThaiThongmee WNarongkhananukul CPadungkiatsagul TJindahra PVanikieti KDove Medical Pressarticlelate-onsetoptic neuritisneuromyelitis optica spectrum disorderthaiOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 419-429 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	late-onset optic neuritis neuromyelitis optica spectrum disorder thai Ophthalmology RE1-994
spellingShingle	late-onset optic neuritis neuromyelitis optica spectrum disorder thai Ophthalmology RE1-994 Thongmee W Narongkhananukul C Padungkiatsagul T Jindahra P Vanikieti K Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes
description	Watcharaporn Thongmee,1 Chanomporn Narongkhananukul,1 Tanyatuth Padungkiatsagul,1 Panitha Jindahra,2 Kavin Vanikieti1 1Department of Ophthalmology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandCorrespondence: Kavin Vanikieti Email Vanikieti.kavin@gmail.comObjective: To compare demographic data, clinical and radiological characteristics, treatments, and long-term visual outcomes between patients with late-onset neuromyelitis optica spectrum disorder-related optic neuritis (LO-NMOSD-ON) (age at onset ≥ 50 years) and patients with early-onset neuromyelitis optica spectrum disorder-related optic neuritis (EO-NMOSD-ON) (age at onset < 50 years).Patients and Methods: This retrospective study included 47 patients (69 eyes) who were diagnosed with neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) over a 12-year period. There were 14 patients (21 eyes) and 33 patients (48 eyes) in the LO-NMOSD-ON and EO-NMOSD-ON groups, respectively.Results: LO-NMOSD-ON–affected eyes exhibited significantly worse median nadir visual acuity (VA) at optic neuritis (ON) onset, compared with EO-NMOSD-ON–affected eyes (2.7 logMAR (range 2.6– 2.9 logMAR) vs 1.95 logMAR (range 0.4– 2.9 logMAR); p = 0.03). Similarly, 100% of LO-NMOSD-ON–affected eyes demonstrated a nadir VA of worse than or equal to 1.0 logMAR, compared with 62.5% of EO-NMOSD-ON–affected eyes (p = 0.03). LO-NMOSD-ON–affected eyes had a worse median final VA, compared with EO-NMOSD-ON–affected eyes (1.3 logMAR (range 0– 2.9 logMAR) vs 0.3 logMAR (range 0– 2.9 logMAR); adjusted p = 0.037). LO-NMOSD-ON–affected eyes more frequently exhibited a final VA of worse than or equal to 1.0 logMAR, compared with EO-NMOSD-ON–affected eyes (57.1% vs 27.0%; adjusted p = 0.039). A positive correlation was observed between age at ON onset of each eye and the final VA (logMAR) (Spearman r = 0.34, p = 0.0075). The remaining parameters did not significantly differ between the two groups.Conclusion: Patients with LO-NMOSD-ON had significantly worse nadir VA at ON onset and significantly worse final VA, relative to patients with EO-NMOSD-ON. Age at ON onset of each eye was positively correlated with final VA (logMAR). Despite the difference in common age at onset, NMOSD-ON should be included in the differential diagnosis of late-onset acute to subacute optic neuropathy, along with ischemic optic neuropathy.Keywords: late-onset, optic neuritis, neuromyelitis optica spectrum disorder, Thai
format	article
author	Thongmee W Narongkhananukul C Padungkiatsagul T Jindahra P Vanikieti K
author_facet	Thongmee W Narongkhananukul C Padungkiatsagul T Jindahra P Vanikieti K
author_sort	Thongmee W
title	Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes
title_short	Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes
title_full	Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes
title_fullStr	Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes
title_full_unstemmed	Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes
title_sort	comparison of early- and late-onset nmosd-related optic neuritis in thai patients: clinical characteristics and long-term visual outcomes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/8a32247d2cea46828c97b446b38dac43
work_keys_str_mv	AT thongmeew comparisonofearlyandlateonsetnmosdrelatedopticneuritisinthaipatientsclinicalcharacteristicsandlongtermvisualoutcomes AT narongkhananukulc comparisonofearlyandlateonsetnmosdrelatedopticneuritisinthaipatientsclinicalcharacteristicsandlongtermvisualoutcomes AT padungkiatsagult comparisonofearlyandlateonsetnmosdrelatedopticneuritisinthaipatientsclinicalcharacteristicsandlongtermvisualoutcomes AT jindahrap comparisonofearlyandlateonsetnmosdrelatedopticneuritisinthaipatientsclinicalcharacteristicsandlongtermvisualoutcomes AT vanikietik comparisonofearlyandlateonsetnmosdrelatedopticneuritisinthaipatientsclinicalcharacteristicsandlongtermvisualoutcomes
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Comparison of Early- and Late-Onset NMOSD-Related Optic Neuritis in Thai Patients: Clinical Characteristics and Long-Term Visual Outcomes

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