Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

Abstract In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs (ES-NMDARs) dependent LTP haven’t be...

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Autores principales:	Qian Yang, Geng Zhu, Dandan Liu, Jue-Gang Ju, Zhen-Hua Liao, Yi-Xin Xiao, Yue Zhang, Naijian Chao, JieJie Wang, Weidong Li, Jian-Hong Luo, Sheng-Tian Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8a36747c080b4414902f586cc6581f75
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spelling	oai:doaj.org-article:8a36747c080b4414902f586cc6581f752021-12-02T12:32:18ZExtrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons10.1038/s41598-017-03287-72045-2322https://doaj.org/article/8a36747c080b4414902f586cc6581f752017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03287-7https://doaj.org/toc/2045-2322Abstract In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs (ES-NMDARs) dependent LTP haven’t been reported. Here, through the use of a 5-Hz stimulation and MK-801 (an irreversible antagonist of NMDARs) in the CA1 neurons of adult mice hippocampal slices, synaptic NMDARs were selectively inhibited and NMDAR-mediated excitatory postsynaptic currents were not recovered. We found that a robust LTP was induced by 3-train 100-Hz stimulation when the synaptic NMDARs and extrasynaptic NR2B containing NMDARs were blocked, but not in the any of the following conditions: blocking of all NMDARs (synaptic and extrasynaptic), blocking of the synaptic NMDARs, and blocking of the synaptic NMDARs and extrasynaptic NR2A-containing NMDARs. The results indicate that this LTP is ES-NMDARs dependent, and NR2B-containing ES-NMDARs modulates the threshold of LTP induction.Qian YangGeng ZhuDandan LiuJue-Gang JuZhen-Hua LiaoYi-Xin XiaoYue ZhangNaijian ChaoJieJie WangWeidong LiJian-Hong LuoSheng-Tian LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qian Yang Geng Zhu Dandan Liu Jue-Gang Ju Zhen-Hua Liao Yi-Xin Xiao Yue Zhang Naijian Chao JieJie Wang Weidong Li Jian-Hong Luo Sheng-Tian Li Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
description	Abstract In the adult mouse hippocampus, NMDA receptors (NMDARs) of CA1 neurons play an important role in the synaptic plasticity. The location of NMDARs can determine their roles in the induction of long-term potentiation (LTP). However, the extrasynaptic NMDARs (ES-NMDARs) dependent LTP haven’t been reported. Here, through the use of a 5-Hz stimulation and MK-801 (an irreversible antagonist of NMDARs) in the CA1 neurons of adult mice hippocampal slices, synaptic NMDARs were selectively inhibited and NMDAR-mediated excitatory postsynaptic currents were not recovered. We found that a robust LTP was induced by 3-train 100-Hz stimulation when the synaptic NMDARs and extrasynaptic NR2B containing NMDARs were blocked, but not in the any of the following conditions: blocking of all NMDARs (synaptic and extrasynaptic), blocking of the synaptic NMDARs, and blocking of the synaptic NMDARs and extrasynaptic NR2A-containing NMDARs. The results indicate that this LTP is ES-NMDARs dependent, and NR2B-containing ES-NMDARs modulates the threshold of LTP induction.
format	article
author	Qian Yang Geng Zhu Dandan Liu Jue-Gang Ju Zhen-Hua Liao Yi-Xin Xiao Yue Zhang Naijian Chao JieJie Wang Weidong Li Jian-Hong Luo Sheng-Tian Li
author_facet	Qian Yang Geng Zhu Dandan Liu Jue-Gang Ju Zhen-Hua Liao Yi-Xin Xiao Yue Zhang Naijian Chao JieJie Wang Weidong Li Jian-Hong Luo Sheng-Tian Li
author_sort	Qian Yang
title	Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
title_short	Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
title_full	Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
title_fullStr	Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
title_full_unstemmed	Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons
title_sort	extrasynaptic nmda receptor dependent long-term potentiation of hippocampal ca1 pyramidal neurons
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8a36747c080b4414902f586cc6581f75
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_version_	1718394106818854912

Extrasynaptic NMDA receptor dependent long-term potentiation of hippocampal CA1 pyramidal neurons

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